Advances in Molecular OncologyAdvances in Molecular OncologyУспехи молекулярной онкологии2313-805X2413-3787Publishing House ABV Press20310.17650/2313-805X-2019-6-1-18-36REVIEW ARTICLESОБЗОРНЫЕ СТАТЬИModulation of the formation of active forms of nitrogen by ingredients of plant products in the inhibition of carcinogenesisМодулирование образования активных форм азота ингредиентами растительных продуктов при ингибировании канцерогенезаDeryaginaV. P.ДерягинаВ. П.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478.

Дерягина Валентина Петровна.

115478 Москва, Каширское шоссе, 24.

derygina@inbox.ruReutovV. P.РеутовВ. П.
Russian Federation

5a Butlerova St., Mosсow 117485.

117485 Москва, ул. Бутлерова, 5а.

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaНациональный медицинский исследовательский центр онкологии им. Н.Н. Блохина Минздрава РоссииInstitute of Higher Nervous Activity and Neurophysiology of the Russian Academy of SciencesИнститут высшей нервной деятельности и нейрофизиологии РАН150120196118362704201927042019Copyright ©; 2019, Deryagina V.P., Reutov V.P.Copyright ©; 2019, Дерягина В.П., Реутов В.П.2019Deryagina V.P., Reutov V.P.Дерягина В.П., Реутов В.П.https://creativecommons.org/licenses/by/4.0https://umo.abvpress.ru/jour/article/view/203

The review analyzes literature data and the results of our own research on the role of reactive nitrogen species (NO, NO2, N2O3) in the initiation and progression of tumors. The possibility of modulating the activity of inducible NO synthase by the biologically active components of plant products and their effect on carcinogenesis is analyzed. Possible mechanisms of the ambiguous action of NO and its metabolic products in the mechanisms of carcinogenesis are discussed. The generalization and analysis of these data allowed us to formulate some principles for the use of substances that modulate the activity of inducible NO synthase and affect the formation of NO and its metabolic products in inhibiting carcinogenesis.

В обзоре анализируются данные литературы и результаты собственных исследований о роли активных форм азота (NO, NO2, N2O3) в инициации и прогрессии опухолей. Анализируется возможность модуляции активности индуцибельной NO-синтазы биологически активными компонентами растительных продуктов и их влияние на канцерогенез. Обсуждаются возможные механизмы неоднозначного действия NO и продуктов его метаболизма в канцерогенезе. Обобщение и анализ этих данных позволили сформулировать некоторые принципы применения веществ, модулирующих активность индуцибельной NO-синтазы и влияющих на образование NO и продуктов его метаболизма при ингибировании канцерогенеза.

nitric oxideactive forms of nitric oxideinducible NO-synthasecycle of nitric oxidecarcinogenesisbiologically active component of plant productsоксид азотаактивные формы оксида азотаиндуцибельная NO-синтазацикл оксида азотаканцерогенезбиологически активный компонент растительных продуктовCoussens L.M., Werb Z. Inflammation and cancer. Nature 2002;420(6917): 860-7. DOI: 10.1038/nature01322. PMID: 12490959.Vannini F., Kashfi Kh., Nath N. The dual role of iNOS in cancer. Redox Biol 2015;6:334-43. DOI: 10.1016/j.redox.2015.08.009. PMID: 26335399.Thomas D.D., Ridnour L.A., Isenberg J.S. et al. The Chemical biology of nitric oxide. Implication in Cellular Signaling. Free Radic Biol Med 2008;45(1):18-316. DOI: 10.1016/j.freeradbiomed.2008.03.020. PMID: 18439435.Benetou V., Orfanos P., Lagiou P. et al. Vegetables and fruits in relation to cancer risk: evidence from the Greek EPIC cohort study. Cancer Epidemiol Biomarkers Prev 2008;17(2):387-92. DOI: 10.1158/1055-9965.EPI-07-2665. PMID: 18268122.Kaur V., Kumar M., Kumar A. et al. Pharmacotherapeutic potencial of phytochemicals: implications in cancer chemoprevention and future perspectives. Biomed Pharmacother 2018;97:564-86. DOI: 10.1016/j.biopha.2017.10.124. PMID: 29101800.Weng Ch.J., Yen G.Ch. Chemopreventive effects of dietary phytochemicals against cancer invasion and metastasis: phenolic acids, monophenol, polyphenol, and their derivatives. Cancer Treat Rev 2012;38(1):76—87. DOI: 10.1016/j.ctrv.2011.03.001. PMID: 21481535.Steward W.P., Brown K. Cancer chemoprevention: a rapidly evolving field. British J Cancer 2013;109(1):1-7. DOI: 10.1038/bjc.2013.280. PMID: 23736035.IARC monographs. Ingested nitrate and nitrite, and cyanobacterial peptide toxins. Vol. 94. Lyon, 2010. Pp. 45-325.Deryagina V.P., Mashkovtsev Yu.V., Ilnitsky A.P. Experimental study of the functional activity of neutrophils and macrophages under conditions of exposure to sodium nitrite. Biomeditsinskaya khimiya = Biomedical Chemistry 2003;49(1):19—26. (In Russ.).Дерягина В.П., Машковцев Ю.В., Ильницкий А.П. Экспериментальное изучение функциональной активности нейтрофилов и макрофагов в условиях воздействия нитрита натрия. Биомедицинская химия 2003;49(1):19-26.Harmful substances in industry. Vol. 3. Leningrad: Khimiya, 1977. 607 p. (In Russ.).Вредные вещества в промышленности. Том 3. Ленинград: Химия, 1977. 607 с.Zhukova G.F., Arkhipov G.N., Ivashkina A.S., Pimenova V.V. The carcinogenic effect of precursors when administered to mice in conjunction with inhibitors. In: The biological effect of carcinogenic nitroso compounds. Pskov. L.: b. i., 1980. Pp. 55-57. (In Russ.).Жукова Г.Ф., Архипов Г.Н., Ивашкина А.С., Пименова В.В. Канцерогенное действие предшественников при введении внутрь мышам совместно с ингибиторами. В кн.: Биологический эффект канцерогенных нитрозосоединений. Псков. Л.: б. и., 1980. С. 55-57.Yurchenko V.A., Ilnitsky A.P., Ermilov I.B. et al. Formation of carcinogenic nitrosamines from a small amount of precursors in human gastric juice. Eksperimental’naya onkologiya = Experimental Oncology 1990;12(2):24—6. (In Russ.).Юрченко В.А., Ильницкий А.П., Ермилов И.Б. и др. Образование канцерогенных нитрозаминов из малого количества предшественников в желудочном соке человека. Экспериментальная онкология 1990;12(2):24—6.Reutov V.P., Sorokina E.G., Okhotin V.E., Kositsyn N.S. Cyclic transformations of nitric oxide in mammals. Moscow: Nauka, 1997. 156 p. (In Russ.).Реутов В.П., Сорокина Е.Г., Охотин В.Е., Косицын Н.С. Циклические превращения оксида азота в организме млекопитающих. М.: Наука, 1997. 156 c.Zhang X., Lin Y., Gillies R.J. Tumor pH and its measurement. J Nucl Med 2010;51(8):1167-70. DOI: 10.2967/jnumed.109.068981. PMID: 20660380.Zhang X., Lin Y., Gillies R.J. Tumor pH and its measurement. J Nucl Med 2010;51(8):1167—70. DOI: 10.2967/jnumed.109.068981. PMID: 20660380.Ilnitsky A.P., Reutov V.P., Ryzhova N.I. et al. Urethane-induced pulmonary adenoma and Rausher’s leukemia modified by sodium nitrite in mice: a possible role for nitric oxide and nitric dioxide. Exp Oncol 1997;19:101-9.Ilnitsky A.P., Ryzhova N.I., Chudina A.P. et al. The potentiating effect of sodium nitrite on the development of spontaneous and 1,2-dimethylhydrazine-induced tumors in F1 male mice(C57BlxCBA). Voprosy onkologii = Oncology Issues 2004;50(6):683-8 (In Russ.).Ильницкий А.П., Рыжова Н.И., Чудина А.П. и др. Потенцирующее действие нитрита натрия на развитие спонтанных и индуцированных 1,2-диметилгидразином опухолей у мышей-самцов F1 (C57BlxCBA). Вопросы онкологии 2004;50(6):683-8.Ilnitsky A.P., Yurchenko V.A., Zhukova G.F., Ermilov V.B. Assessment of the carcinogenic risk of low doses of nitrite. Voprosy pitaniya = Nutrition Issues 1989;35(7):843-8. (In Russ.).Ильницкий А.П., Юрченко В.А., Жукова Г.Ф., Ермилов В.Б. Оценка степени канцерогенной опасности малых доз нитритов. Вопросы питания 1989;35(7):843-8.Reutov V.P. The cycle of nitric oxide in mammals and the principle of cyclicity. Biokhimiya = Biochemistry 2002;67(3):353-76. (In Russ.).Реутов В.П. Цикл оксида азота в организме млекопитающих и принцип цикличности. Биохимия 2002;67(3):353-76.Reutov V.P., Azhipa Ya.I., Kayushin L.P. The study by the method of electron paramagnetic resonance products of the interaction of nitrogen oxides with some organic compounds. Byulleten’ eksperimental’noy biologii i meditsiny = Bulletin of Experimental Biology and Medicine 1978;9:299-301. (In Russ.).Реутов В.П., Ажипа Я.И., Каюшин Л.П. Изучение методом электронного парамагнитного резонанса продуктов взаимодействия окислов азота с некоторыми органическими соединениями. Бюллетень экспериментальной биологии и медицины 1978;9:299-301.Reutov V.P., Azhipa Ya.I., Kayushin L.P. The study of paramagnetic centers arising from the interaction of nitrogen dioxide with oleic acid and tyrosine. Doklady Akademii nauk SSSR = Report Academy of Sciences of the USSR 1978;241(6):1375-7. (In Russ.).Реутов В.П., Ажипа Я.И., Каюшин Л.П. Исследование парамагнитных центров, возникающих при взаимодействии двуокиси азота с олеиновой кислотой и тирозином. Доклады Академии наук СССР 1978;241(6):1375-7.Reutov V.P., Orlov S.N. The physiological significance of guanylate cyclase and the role of nitric oxide and nitro compounds in the regulation of the activity of this enzyme. Fiziologiya cheloveka = Human Physiology 1993;19(1):124—37. (In Russ.).Реутов В.П., Орлов С.Н. Физиологическое значение гуанилатциклазы и роль окиси азота и нитросоединений в регуляции активности этого фермента. Физиология человека 1993;19(1):124-37.Ignarro L.J., Buga G.M., Wood K.S. et al. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci USA 1987;84:9265-9. PMID: 2827174.Forstermann U., Sessa W.C. Nitric oxide synthases: regulation and function. Eur Heart J 2012;33(7):829-37. DOI: 10.1093/eurheartj/ehr304. PMID: 21890489.Forstermann U., Sessa W.C. Nitric oxide synthases: regulation and function. Eur Heart J 2012;33(7):829—37. DOI: 10.1093/eurheartj/ehr304. PMID: 21890489.Tendler D.S., Bao C., Wang T. et al. Intersection of interferon and hypoxia signal transduction pathways in nitric oxide-induced tumor apoptosis. Cancer Res 2001;61(9):3682-8. PMID: 11325839.Tendler D.S., Bao C., Wang T. et al. Intersection of interferon and hypoxia signal transduction pathways in nitric oxide-induced tumor apoptosis. Cancer Res 2001;61(9):3682—8. PMID: 11325839.Nathan C.F., Hibbs J.B. Role of nitric oxide synthesis in macrophage antimicrobial activity. Curr Opin Immunol 1991;3(1):65-70. PMID: 1711326.Alderton W.K., Cooper C.E., Knowles R.G. Nitric oxide synthases: structure, function and inhibition. Biochem J 2001;357: 593-615. PMID: 11463332.Zaporozhan V.N., Gozhenko A.I., Korneenko T.V., Dubinina V.G. Biological E activity of nitric oxide in the mechanisms of tumor growth. Uspekhi fiziologicheskikh nauk = Advances in Physiological Sciences 2004;35(1):66-82. (In Russ.).Запорожан В.Н., Гоженко А.И., Корнеенко Т.В., Дубинина В.Г. Биологическая активность оксида азота в механизмах опухолевого роста. Успехи физиологических наук 2004;35(1): 66-82.Zenkov N.K., Men’shchikova E.B., Reutov V.P. NO synthase is normal and in the pathology of various genesis. Vestnik RAMN = Bulletin of RAMS 2000;4:30-4. (In Russ.).Зенков Н.К., Меньщикова Е.Б., Реутов В.П. NO-синтазы в норме и при патологии различного генеза. Вестник РАМН 2000;4:30-4.Deryagina V.P., Ryzhova N.I., Krivosheeva L.V., Golubeva I.S. Formation of nitric oxide metabolites during growth of transplanted tumors with different metastatic potential. Biochemistry (Moscow). Suppl. Series B: Biomed Chemistry 2015;9(2):130-6. DOI: 10.1134/S1990750815020055.Kondakova I.V., Zagrebelnaya G.V., Reutov V.P. Effect of peroxide radicals and nitric oxide on the proliferating activity of tumor cells. Izvestiya Natsional’noy akademii nauk Belarusi. Ceriya medico-biologicheskikh nauk = News of the National Academy of Sciences of Belarus. Biomedical Science Series 2003;1:78-82. (In Russ.).Кондакова И.В., Загребельная Г.В., Реутов В.П. Влияние пероксидных радикалов и оксида азота на пролиферирующую активность опухолевых клеток. Известия Национальной академии наук Беларуси. Серия медико-биологических наук 2003;1:78-82.Reutov V.P. Nitric oxide cycle in mammals and the cyclicity principle. Biochemistry (Moscow) 2002;67(3):293-311. PMID: 11970729.Reutov V.P. Nitric oxide cycle in mammals and the cyclicity principle. Biochemistry (Moscow) 2002;67(3):293—311. PMID: 11970729.Bonavida B., Khineche S., Huerta-Yepez S., Garban H. Therapeutic potential of nitric oxide in cancer. Drug Resist Updates 2006;9(3):157-73. DOI: 10.1016/j.drup.2006.05.003. PMID: 16822706.Pautz A., Art J., Hahn S. Regulation of the expression of inducible nitric oxide synthase. Nitric Oxide 2010;23:75-93. DOI: 10.1016/j.niox.2010.04.007. PMID: 20438856.Deryagina V.P. The formation of free radical compounds under the action of sodium nitrite on the organism of animals and in vitro. Toksikologicheskiy vestnik = Toxicological messenger 2003;6:20-5. (In Russ.).Дерягина В.П. Образование свободно-радикальных соединений при действии условиях in vitro. Токсикологический вестник 2003;6:20-5.Menshikova E.B., Zenkov N.K., Reutov V.P. Nitric oxide and NO-synthase in mammals in different functional states. Biochemistry (Moscow) 2000;65(4): 409-26.Reutov V.P., Kayushin L.P., Sorokina E.G. Physiological role of nitric oxide cycle in human and animal organism. Hum Physiol 1994;20:219-29.Friebe A., Koesling D. Regulation of nitric oxide-sensitive guanylyl cyclase. Circ Res 2003;93:96-105. DOI: 10.1161/01.RES.0000082524.34487.31. PMID: 12881475.Dangel O., Mergia E., Karlisch K. et al. Nitric oxide-sensitive guanylyl cyclase is the only nitric oxide receptor mediating platelet inhibition. J Thromb Haemost JTH 2010;8:1343-52. DOI: 10.1111/j.1538-7836.2010.03806.x. PMID: 20149081.Heinrich T.A., da Silva R.S., Miranda K.M. et al. Biological nitric oxide signaling: chemistry and terminology. Brit J Pharmac 2013;169(7):1417-29. DOI: 10.1111/bph.122. PMID: 23617570.Wink D.A., Kaspizak K.S., Maragos C.M. et al. DNA deaminating ability and genotoxicity of nitric oxide and its progenitors. Science 1991;254(5034): 1001-3. PMID: 1948068.Azad N., Vallyathan V., Wang L. et al. S-nitrosylation of Bcl-2 inhibits its ubiquitin-proteasomal degradation. A novel antiapoptic mechanism that suppressed apoptosis. J Biol Chem 2006;281:34124-34. DOI: 10.1074/jbc.M602551200. PMID: 16980304.Wright C., Iyer A.K., Kulkarni Y., Azad N. S-Nitrosylation of Bcl-2 negatively affects autophagy in lung epithelial cells. J Cell Biochem 2016;117(2):521-32. DOI: 10.1002/jcb.25303. PMID: 26241894.Raines K.W., Bonini M.G., Campbell S.L. Nitric Oxide cell signaling: S-nitrosation of Ras superfamily GTPases. Cardiovasc Res 2007;75(2):229-39. DOI: 10.1016/j.cardiores.2007.04.013. PMID: 17559822.Lee S.Y., Rim Y., McPherson D.D. et al. A novel liposomal nanomedicine for nitric oxide delivery and breast cancer treatment. Biomed Mater Eng 2014;24(1):61-7. DOI: 10.3233/BME-130784. PMID: 24211883.Ambs S., Merriam W.G., Bennett W.P. et al. Frequent nitric oxide synthase-2expression in human colon adenomas: implication for tumor angiogenesis and colon cancer progression. Cancer Res 1998;58(2):334-41. PMID: 9443414.Gallo O., Masini E., Morbidelli L. et al. Role of nitric oxide in angiogenesis and tumor progression in head and neck cancer. J Natl Cancer Inst 1998;90(8):587-96. PMID: 9554441.Thomas D.D., Espey M.G., Ridnour L.A. et al. Hypoxic inducible factor 1 alpha, extracellular signal-regulated kinase, and p53 are regulated by distinct threshold concentrations of nitric oxide. Proc Natl Acad Sci USA 2004;101(24):8894-9. DOI: 10.1073/pnas.0400453101. PMID: 15178764.Espey M.G., Miranda K.M., Pluta R.M., Wink D.A. Nitrosative capacity of macrophages is dependent on nitricoxide synthase induction signals. J Biol Chem 2000;275(15):11341-7. DOI: 10.1074/jbc.275.15.11341. PMID: 10753947.Ambs S., Hussain S.P., Harris C.C. Interactive effects of nitric oxide and the p53 tumor suppressor gene in carcinogenesis and tumor progression. FASEB J 1997;11(6):443-8. PMID: 9194524.Kim Y.M., Talanian R.V., Billiar T.R. Nitric oxide inhibits apoptosis by preventing increases in caspase-3-like activity via two distinct mechanisms. J Biol Chem 1997;272(49):31138-48. PMID: 9388267.Kotamraju S., Tampo Y., Keszler A. et al. Nitric oxide inhibits H2O2-induced trancferrin receptor-dependent apoptosis in endothelial cells: role ubiquitin-proteasome pathway. Proc Natl Acad Sci USA 2003;100(19):10653-8. DOI: 10.1073/pnas.1933581100. PMID: 12958216.Granik V.G., Grigoriev N.B. Nitric oxide (NO). Moscow: Vuzovskaya kniga, 2004. 360 p. (In Russ.).Граник В.Г., Григорьев Н.Б. Оксид азота (NO). М.: Вузовская книга, 2004. 360 с.Crowell J.A., Steele V.E., Sigman C.C., Fay J.R. Is inducible nitric oxide synthase a target for chemoprevention? Mol Cancer Ther 2003;2(8):815-23. PMID: 12939472.Janakiram N.B., Rao Ch.V. iNOS-selective inhibitors for cancer prevention: promise and progress. Future Med Chem 2012;4(17):2193-204. DOI: 10.4155/fmc.12.168. PMID: 23190107.Rigas B. Novel agents for cancer preven-tion based on nitric oxide. Bioch Soc Trans 2007;35(Pt5):1364-8. DOI: 10.1042/BST0351364. PMID: 17956352.Rigas B. Novel agents for cancer prevention based on nitric oxide. Bioch Soc Trans 2007;35(Pt5):1364-8. DOI: 10.1042/BST0351364. PMID: 17956352.Rao C.V., Reddy B.S, Steele V.E. et al. Nitric oxide-releasing aspirin and indomethacin are potent inhibitors against colon cancer in azoxymethane-treatedrats: effects on molecular targets. Mol Cancer Ther 2.006;5(6):1530-8. DOI: 10.1158/1535-7163.MCT-06-0061. PMID: 16818512.Deryagina V.P., Lyubchanskaya V.M., Ryzhova N.I. et al. The growth dynamics of Ehrlich carcinoma in F1 mice under the influence of NO donors — derivatives of 3-nitrobenzofuran and 3-nitroindole. Rossiyskiy bioterapevticheskiy zhurnal = Russian Biotherapeutic Journal 2009;(1):60-3. (In Russ.).Дерягина В.П., Любчанская В.М., Рыжова Н.И. и др. Динамика роста карциномы Эрлиха у мышей F1 под воздействием доноров NO — производных 3-нитробензофурана и 3-нитроиндола. Российский биотерапевтический журнал 2009;(1):60-3.Deryagina V.P., Ryzhova N.I. The effect of NO synthase modulators on the growth of Ehrlich transplantable adenocarcinoma. Vestnik RONTS im. N.N. Blokhina = Bulletin of the Russian Cancer Research Center. N.N. Blokhin RAMS 2007;18(2):32-8. (In Russ.).Дерягина В.П., Рыжова Н.И. Действие модуляторов NO-синтаз на рост перевивной аденокарциномы Эрлиха. Вестник РОНЦ им. Н.Н. Блохина РАМН 2007;18(2):32—8.Kashfi K., Rigas B. Molecular targets of nitric-oxide-donating aspirin in cancer. Biochem Soc Trans 2005;33(Pt):701-4. DOI: 10.1042/BST0330701. PMID: 16042578.Kashfi K., Rigas B. Molecular targets of nitric-oxide-donating aspirin in cancer. Biochem Soc Trans 2005;33(Pt):701—4. DOI: 10.1042/BST0330701. PMID: 16042578.Thomsen L.L., Scott J.M.J., Topley P. et al. Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: studies with 1400 W, a novel inhibitor. Cancer Res 1997;57:3300-4. PMID: 9242464.Tang W., Li H., Poulos T.L., Silverman R.B. Mechanistic studies of inactivation of inducible nitric oxide synthase by amidines. Biochemistry 2015;54(15):2530—8. DOI: 10.1021/acs.biochem.5b00135. PMID: 25811913.Deryagina V.P., Ryzhova N.I., Golubkina N.A. Production of nitrogen oxide derivatives under the influence of NO-synthase inhibitors and natural compounds in mice with transplanted tumors. Exp Oncol 2012;34(1):1-5. PMID: 22453145.Deychman G.I. The role of natural resistance in the body’s response to the occurrence, growth and metastasis of tumors. Itigi nauki i tekhniki = Results of science and technology 1984;13:46-97. (In Russ.).Дейчман Г.И. Роль естественной резистентности в реакции организма на возникновение, рост и метастазирование опухолей. Итоги науки и техники 1984;13:46-97.Perrotta C., Cervia D., Di Renzo I. et al. Nitric oxide generated by tumor-associated macrophages is responsible for cancer resistance to cisplatin and corelatedwith syntaxin 4 and acid sphingomyelinase inhibition. Front Immunol 2018;9:1186. DOI:10.3389/fimmu2018.01186. PMID: 29896202.Perrotta C., Cervia D., Di Renzo I. et al. Nitric oxide generated by tumor-associated macrophages is responsible for cancer resistance to cisplatin and corelatedwith syntaxin 4 and acid sphingomyelinase inhibition. Front Immunol 2018;9:1186. DOI: 10.3389/fimmu2018.01186. PMID: 29896202.Fresco P., Borges F., Diniz C., Marques M.P. New insights on the anticancer properties of dietary polyphenols. Med Res Rev 2006;26(6):7-66. DOI:10.1002/med.20060. PMID:16710860.Maldonado-Rojas W., Olivero-Verbel J. Food-related compounds that modulate expression of inducible nitric oxide synthase may act as its inhibitors. Molecules 2012;17(7):8118-35. DOI: 10.390/molecules 17078118. PMID: 22766803.Maldonado-Rojas W., Olivero-Verbel J. Food-related compounds that modulate expression of inducible nitric oxide synthase may act as its inhibitors. Molecules 2012;17(7):8118-35. DOI: 10.390/molecules17078118. PMID: 22766803.Quideau S., Deffieux D., Douat-Casassus C., Pouysegu L. Plant polyphenols: chemical properties, biological activities, and synthesis. Angew Chem Int Ed 2011;50:586-621. DOI:10.1002/anie.201000044. PMID: 21226137.Azqueta A., Collins A. Polyphenols and DNA damage: a mixed blessing. Nutrients 2016;8(12):785. DOI: 10.3390/nu8120785. PMID: 27918471.Hara A., Okayasu I. Cyclooxygenase-2 and inducible nitric oxide synthase expression in human astrocytic gliomas: correlation with angiogenesis and prognostic significance. Acta Neuropathol 2004;108(1):43—8. DOI: 10.1007/s00401-004-0860-0. PMID: 15088099.Hara A., Okayasu I. Cyclooxygenase-2 and inducible nitric oxide synthase expression in human astrocytic gliomas: correlation with angiogenesis and prognostic significance. Acta Neuropathol 2004;108(1):43-8. DOI: 10.1007/s00401-004-0860-0. PMID: 15088099.Kim Y.A., Lim S.Y., Rhee S.H. et al. Resveratrol inhibits inducible nitric oxide synthase and cyclooxygenase-2 expression in beta-amyloid-treated C6 glioma cells. Int J Mol Med 2006;17(6):1069-75. PMID:16685418.Holian O., Wahid S., Atten M.J., Attar B.M. Inhibition of gastric cancer cell proliferation by resveratrol: role of nitric oxide. Am J Physiol Gastrointest Liver Physiol 2002;282(5):G809-16. DOI: 10.1152/ajpgi.00193.2001. PMID: 11960777.Notas G., Nifli A.P., Kampa M. et al. Resveratrol exerts its antiproliferative effect on HepG2 hepatocellular carcinoma cells, by inducing cell cycle arrest, and NOS activation. Biochem Biophys Acta 2006;1760:1657-66. DOI: 10.1016/j.bbagen.2006.09.010. PMID: 17052855.Billard C., Izard J.C., Roman V. et al. Comparative antiproliferative and apoptic effects of resveratrol, epsilon viniferin and vine-shots derived polyphenols (vineatrols) on chronic B lymphocytic leukemia cells and normal human lymphocytes. Leuk Lymphoma 2002;43(10):1991-2002. DOI: 10.1080/1042819021000015952. PMID: 12481898.Nanjoo S., Shiby P., Xingpei H. et al. Pterostilbene, an active constituent of blueberries, suppresses aberrant crypt foci formation in the azoxymethaneinduced colon carcinogenesis model inrats. Clin Cancer Research 2007;13(1):350—5. DOI: 10.1158/1078-0432.CCR-06-1528. PMID: 17200374.Nechuta S., Shu X.O., Li H.L. et al. Prospective cohort study of tea consumption and risk of digestive system cancers: results from the Shanghai women’s health study. J Clin Nutr 2012;96(5):1056-63. DOI: 10.3945/ajcn.111.031419. PMID: 23053557.Chan M.M., Fong D., Ho C.T., Huang H.I. Inhibition of inducible nitric oxide synthase gene expression and enzyme activity by epigallocatechin gallate, a natural product from green tea. Biochem Pharmacol 1997;54(12):1281-6. PMID: 9393670.Singh R., Ahmed S., Islam N. et al. Epigallocatechin-3-gallate inhibits interleukin-1beta-induced expression of nitric oxide synthase and production of nitric oxide in human chondrocytes: suppression of nuclear factor kappaB activation by degradation of the inhibitor of nuclear factor kappaB. Arthritis Rheum 2002;46(8):2079-86. DOI: 10.1002/art.10443. PMID: 12209512.Singh R., Ahmed S., Islam N. et al. Epigallocatechin-3-gallate inhibits interleukin-1beta-induced expression of nitric oxide synthase and production of nitric oxide in human chondrocytes: suppression of nuclear factor kappa B activation by degradation of the inhibitor of nuclear factor kappaB. Arthritis Rheum 2002;46(8):2079-86. DOI: 10.1002/art.10443. PMID: 12209512.Salmani J.M.M., Zhang X.P., Jacob J.A., Chen B.A. Apigenin’s anticancer properties and molecular mechanisms of action: recent advances and future prospectives. Chin J Natur Med 2017;15(5):321-9. DOI: 10.1016/S1875-5364(17)30052-3. PMID: 28558867.Shankar E., Goel A., Gupta K., Gupta S. Plant flavone apigenin: an emerging anticancer agent. Curr Pharmacol Rep 2017;3(6):423-46. DOI: 10.1007/s40495-017-0113-2. PMID: 29399439.Chen J., Chen A.Y., Huang H. et al. The flavonoid nobiletin inhibits tumor growth and angiogenesis of ovarian cancer via the Akt pathway. Int J Oncol 2015;46(6): 2629-38. DOI: 10.3892/ijo.2015.2946. PMID: 25845666.Nishino H., Tokuda H., Satomi Y. et al. Cancer prevention by antioxidants. Biofactors 2004;22(1—4):57-61. PMID: 15630252.Applegate C.C., Rowles J.L., Ranard K.M. et al. Soy consumption and risk of prostate cancer: an updated systematic review and meta-analysis. Nutrients 2018;10(1). DOI: 10.3390/nu10010040. PMID: 29300347.Ravindranath M.H., Muthugounder S., Presser N., Viswanathan S. Anticancer therapeutic potential of soy isoflavone, genestein. Adv Exp Med Biol 2004;546(1):121-65. PMID: 15584372.Feinstein D.L., Galea E., Cermak J. et al. Nitric oxide synthase expression in glial cells: suppression by tyrosine kinase inhibitors. J Neurochem 1994;62(2):811-4. PMID: 7507517.Faried A., Kurnia D., Faried L.S. et al. Anticancer effects of gallic acid isolated from Indonesian herbal medicine, Phaleria macrocarpa (Scheff.) Boerl, on human cancer cell lines. Int J Oncol 2007;30(3):605-13. PMID: 17273761.Sourani Z., Pourgheysari B., Beshkar P. et al. Gallic acid inhibits proliferation and induces apoptosis in lymphoblastic leukemia cell line (C121). Iran J Med Sci 2016;41(6):525-30. PMID: 27853333.Antoshina E.E., Gorkova T.G., Deryagina V.P., Ryzhova N.I. The inhibitory effect of phenolic acids and various forms of microalgae spirulina on the growth of Ehrlich carcinoma in mice. Vestnik RONTS im. N.N. Blokhina = Bulletin RCRC them. N.N. Blokhin RAMS 2009;20(4):26-31. (In Russ.).Антошина Е.Е., Горькова Т.Г., Дерягина В.П., Рыжова Н.И. Ингибирующее действие фенольных кислот и разных форм микроводоросли спирулины на рост карциномы Эрлиха у мышей. Вестник РОНЦ им. Н.Н Блохина РАМН 2009;20(4):26-31.Sun Z., Zhou C., Liu F. et al. Inhibition of breast cancer cell survival by xanthohumol via modulation of the Notch signaling pathway in vivo and in vitro. Oncol Lett 2018;15(1):908-16. DOI: 10.3892/ol.2017.7434. PMID: 29422966.Sun Z., Zhou C., Liu F. et al. Inhibition of breast cancer cell survival by xanthohumol via modulation of the Notch signaling pathway in vivo and in vitro. Oncol Lett 2018;15(1):908—16. DOI: 10.3892/ol.2017.7434. PMID: 29422966.Gerhauser C., Alt A., Heiss E. et al. Cancer chemopreventive activity of Xanthohumol, a natural product derived from hop. Mol Cancer Ther 2002;1(11):959-69. PMID: 12481418.Kravchenko L.V., Morozov S.V., Deryagina V.P. et al. Antioxidant status of rats treated with different amounts of lycopene. Byulleten’ eksperimental’noy biologii i meditsiny = Bulletin of Experimental Biology and Medicine 2003;135(4):414-8. (In Russ.).Кравченко Л.В., Морозов С.В., Дерягина В.П. и др. Антиоксидантный статус крыс, получавших разное количество ликопина. Бюллетень экспериментальной биологии и медицины 2003;135(4):414-8.Holzapfel N.P., Shokoohmand A., Wagner F. et al. Lycopene reduced ovarian tumor growth and intraperitoneal metastatic load. Am J Cancer Res 2017;7(6):1322-36. PMID: 28670494.Liu Y., Bi T., Shen G. et al. Lupeol induces apoptosis and inhibits invasion in gallbladder carcinoma GBC-SD cells by suppression of EGFR/MMP9 signaling pathway. Cytotechnology 2016;68(1):123-33. DOI: 10.1007/s10616-014-9763-7. PMID: 25037728.Liu Y., Bi T., Shen G. et al. Lupeol induces apoptosis and inhibits invasion in gallbladder carcinoma GBC-SD cells by suppression of EGFR/MMP9 signaling pathway. Cytotechnology 2016;68(1):123—33. DOI: 10.1007/s10616-014-9763-7. PMID: 25037728.Liu Y., Bi T., Wang G. et al. Lupeol inhibits proliferation and induces apoptosis of human pancreatic cancer PCNA-1 cells through AKT/ERK pathways. Naunyn Schmiedebergs Arch Pharm 2015;388(3):295—304. DOI: 10.1007/s00210-014-1071-4. PMID: 25418891.Liu Y., Bi T., Wang G. et al. Lupeol inhibits proliferation and induces apoptosis of human pancreatic cancer PCNA-1 cells through AKT/ERK pathways. Naunyn Schmiedebergs Arch Pharm 2015;388(3):295-304. DOI: 10.1007/s00210-014-1071-4. PMID: 25418891.Saleem M., Afaq F., Adhami V.M. et al. Lupeol modulates NF-kappaB and PI3K/ Akt pathways and inhibits skin cancer in CD-1 mice. Oncogene 2004;23(300): 5203-14. DOI: 10.1038/sj.onc.120764. PMID: 15122342.Higdon J.V., Delage B., Williams D.E., Dashwood R.H. Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis. Pharm Res 2007;55: 224-36. DOI: 10.1016/j.phrs.2007.01.009. PMID: 17317210.Megna B.W., Carney P.R., Nukaya M. et al. Indole-3-carbinol induces tumor cell death: function follows form. J Surg Res 2016;204(1):47-54. DOI: 10.1016/j.jss.2016.04.021. PMID: 27451867.Deryagina V.P., Ryzhova N.I. Effect of flavonoids and indoles on the growth of adenocarcinoma in mice. Vestnik RONTS im. N.N. Blokhina = Bulletin RCRC them. N.N. Blokhin RAMS 2009;20(1):10-5. (In Russ.).Дерягина В.П., Рыжова Н.И. Влияние флавоноидов и индолов на рост аденокарциномы у мышей. Вестник РОНЦ им. Н.Н. Блохина 2009;20(1):10-5.Bunaciu R.P., Yen A. Retinoid chemoprevention: who can benefit? Curr Pharmacol Rep 2015;1(6):391 —400. DOI: 10.1007/s40495-015-0036-8. PMID: 26539342.Simile M.M., Pagnan G., Pastorino F. et al. Chemopreventive N-(4-hydroxy-phenyl)retinamide (fenretinide) targets deregulated NF-{kappa}B and Mat1A genes in the early stages of rat liver carcinogenesis. Carcinogenesis 2005;26(2):417-27. DOI: 10.1093/carcin/bgh315. PMID: 15498786.Rafa H., Benkhelifa S., Younes S.A. et al. All-trans retinoic acid modulates TLR4/ NF-KB signaling pathway targeting TNF-a and nitric oxide synthase 2 expression in colonic mucosa during ulcerative colitis and colitis associated cancer. Mediators Inflamm 2017;2017:7353252. DOI: 10.1155/2017/7353252. PMID: 28408791.Simeone A.M., Colella S., Krahe R. et al. N-(4-Hydroxyphenyl)retinamide and nitric oxide pro-drugs exhibit apoptotic and anti-invasive effects against bone metastatic breast cancer cells. Carcinogenesis 2006;27(3):568-77. DOI: 10.1093/carcin/bgi233. PMID: 16199439.Stephenson J.A., Al-Taan O., Arshad A. et al. The multifaceted effects of omega-3 polyunsaturated fatty acids on the hallmarks of cancer. J Lipids 2013. DOI: 10.1155/2013/261247. PMID: 23762563.Gu Zh., Shan K., Chen H., Chen Y.Q. n-3 polyunsaturated fatty acids and their rolein cancer chemoprevention. Curr Pharmacol Rep 2015;1(5):283-94. DOI: 10.1007/s40495-015-0043-9. PMID: 26457243.Wink D.A., Vodovoz Y., Laval J. et al. The multifaceted roles of nitric oxide in cancer. Carcinogenesis 1998;19(5):711-21. PMID: 9635855.Ohata T., Fukuda K., Takahashi M. et al. Supression of nitric oxide production in lipopolysaccharide-stimulated macro-phage cells by omega 3 polyunsaturated fatty acids. Japan J Cancer Res 1997;88(3):234—7. PMID: 9140106.Ohata T., Fukuda K., Takahashi M. et al. Supression of nitric oxide production in lipopolysaccharide-stimulated macro-phage cells by omega 3 polyunsaturated fatty acids. Japan J Cancer Res 1997;88(3):234-7. PMID: 9140106.Narayanan B.A., Narayanan N.K., Simi B., Reddy B.S. Modulation of inducible nitric oxide synthase and related proinflammatory genes by the omega-3 fatty acid docosahexaenoic acid in human colon cancer cells. Cancer Res 2003;63(5):972-9. PMID: 12615711.Narayanan BA., Narayanan N.K., Desai D. et al. Effects of a combination of docosahexaenoic acid and 1,4-phenylene bis (methylene) selenocyanate on cyclooxygenase 2, inducible nitric oxide synthase and beta-catenin pathways in colon cancer cells. Carcinogenesis 2004;25(12):2443-9. PMID: 15297372. DOI: 10.1093/carcin/bgh252.Serini S., Calviello G. Modulation of Ras/ERK and phosphoinositide signaling by long-chain n-3 PUFA in breast cancer and their potential complementary role in combination with targeted drugs. Nutrients 2017;9(3):185. DOI:10.3390/nu9030185. PMID: 28241486.Serini S., Calviello G. Modulation of Ras/ERK and phosphoinositide signaling by long-chain n-3 PUFA in breast cancer and their potential complementary role in combination with targeted drugs. Nutrients 2017;9(3):185. DOI: 10.3390/nu9030185. PMID: 28241486.Galley H.F., Walker B.E., Howdle P.D., Webster N.R. Regulation of nitric oxide synthase activity in cultured human endothelial cells: effect of antioxidants. Free Radic Biol Med 1996;21(1):97-101. PMID: 8791097.Mazhar K., Yang Y., Wang Sh. et al. Role of vitamin E in prevention of human esophageal squamous cell carcinoma: a review. Sci Lett 2015;3:89-93.Calvisi D.F., Ladu S., Hironaka K. et al. Vitamin E down-modulates iNOS and NADPH in c-Myc/TGF-alpha transgenic mouse model of liver cancer. J Hepatol 2004;41(5):815-22. DOI: 10.1016/j.jhep.2004.07.030. PMID: 15519655.Mandl J., Szarka A., Banhegyi G. Vitamin C: update on physiology and pharmacology. Br J Pharmacol 2009;157(7):1097-110. DOI: 10.1111/j.1476-5381.2009.00282.x. PMID: 19508394.Mayland C.R., Bennett M.I., Allan K. Vitamin C deficiency in cancer patients. Palliat Med 2005;19:17-20. DOI: 10.1191/0269216305pm970oa. PMID: 15690864.Wu F., Wilson J.X., Tyml K. Ascorbate inhibits iNOS expression and preservesvasoconstrictor responsiveness in skeletal muscle of septic mice. Am J Physiol Regul Integr Comp Physiol 2003;285(1):50-6. DOI: 10.1152/ajpregu.00564.2002. PMID: 12637347.Ichim Th.E., Minev B., Braciak T. et al. Intravenous ascorbic acid to prevent and treat cancer-associated sepsis? J Transl Med 2011. DOI: 10.1186/1479-5876-9-25. PMID: 21375761.Li R. Vitamin C, a multi-tasking molecule, find a molecular target in killing cancer cells. React Oxyg Species (Apex) 2016;1(2):141—56. DOI: 10.20455/ros.2016.829. PMID: 29780883.Li R. Vitamin C, a multi-tasking molecule, find a molecular target in killing cancer cells. React Oxyg Species (Apex) 2016;1(2):141-56. DOI: 10.20455/ros.2016.829. PMID: 29780883.Bartsch H., Frank N. Blocking the endogenous formation of N-nitroso compounds and related carcinogens. IARC Sci Publ 1996;139:189-201. PMID: 8923031.Zhukova G.F., Mikhailova M.V Reducing the level of N-nitrosamine contamination of animal products: survey information. Moscow: VNIITEIagroprom, 1989. 45 p. (In Russ.).Жукова Г.Ф., Михайлова М.В. Снижение уровня загрязненности N-нитрозаминами продуктов животного происхождения: обзорная информация. М.: ВНИИТЭИагропром, 1989. 45 с.Deryagina V.P., Zhukova G.F., Vlaskina S.G. et al. Effect of selenium on the formation of carcinogenic N-nitrosamines. Voprosy pitaniya = Nutrition Issues 1996;3:31-3. (In Russ.).Дерягина В.П., Жукова Г.Ф., Власкина С.Г. и др. Влияние селена на образование канцерогенных N-нитрозоаминов. Вопросы питания 1996;3:31-3.Khotimchenko S.A., Zhukova G.F., Deryagina V.P., Golubkina N.A. Inhibitory effect of selenium on the endogenous synthesis of N-nitroso compounds in rats. Voprosy pitaniya = Nutrition Issues 1997;4:16-8. (In Russ.).Хотимченко С.А., Жукова Г.Ф., Дерягина В.П., Голубкина Н.А. Ингибирующее действие селена на эндогенный синтез N-нитрозосоединений у крыс. Вопросы питания 1997;4:16-8.Bingham S.A., Hughes R., Cross A.J. Effect of white versus red meat on endogenous N-nitrosation in the human colon and further evidence of a dose response. J Nutr 2002;132:3522S-5S. DOI: 10.1093/jn/132.11.3522S. PMID: 12421881.Bingham S. Meat, starch and non-starch polysaccharides, are epidemiological and experimental findings consistent with acquired genetic alterations in sporadic colorectal cancer? Cancer Lett 1997;114(1, 2):25-34. PMID: 9103247.Lewin M.H., Bailey N., Bandaletova T. et al. Red meat enhances the colonic formation of the DNA adduct O6-carboxymethyl guanine: implications for colorectal cancer risk. Cancer Res2006;66(3):1859-65. DOI: 10.1158/0008-5472.CAN-05-2237. PMID: 16452248.Hughes R., Pollock J.R., Bingham S. Effect of vegetables, tea and soy on endogenous N-nitrosation, fecal ammonia, and fecal water genotoxicity during a high red meat diet in humans. Nutr Cancer 2002;42(1):70-7. DOI: 10.1207/S15327914NC421_10. PMID: 12235653.Mirvish S.S., Haorah J., Zhou L. et al. Total N-nitroso compounds and their precursors in hot dogs and in the gastro-intestinal tract and feces of rats and mice: possible etiologic agents for colon cancer. J Nutr 2002;132:3526S-9S. DOI: 10.1093/jn/132.11.3526S. PMID: 12421882.Cross A.J., Greetham H.L., Pollock J.R. et al. Variability in fecal water genotoxicity, determined using the Comet assay, is independent of endogenous N-nitroso compound formation attributed to red meat consumption. Environ Mol Mutagen 2006;47(3):179-84. DOI: 10.1002/em.20181. PMID: 16304669.Zhukova G.F. Development of methodical approaches of hygienic control over the content of N-nitroso compounds in food products, the study of the patterns of their formation and ways to reduce the entry into the human body. Thesis ... of doctor of biological science. Moscow, 1990. 355 p. (In Russ.).Жукова Г.Ф. Разработка методических подходов гигиенического контроля за содержанием в пищевых продуктах N-нитрозосоединений, изучение закономерностей их образования и способов снижения поступления в организм человека. Дис. ... д-ра биол. наук. М., 1990. 355 с.Myte R., Gylling B., Haggstrom J. et al. Untangling the role of onecarbon metabolism in colorectal cancer risk: a comprehensive Bayesian network analysis. Sci Rep 2017;7:43434. PMID: 28233834. DOI:10.1038/strep43434.Eizirik D.L., Sandler S., Welsh N. et al. Nicotinamide decreases nitric oxide production and partially protects human pancreatic islets against the suppressive effects of combinations of cytokines. Autoimmunity 1994;19(3):193-8. PMID: 7605871.Komatsu S., Yanaka N., Matsubara K. et al. Antitumor effect of vitamin B6 and its mechanisms. Biochim Biophys Acta 2003;1647(1-2):127-30. PMID: 12686121.Komatsu S., Yanaka N., Matsubara K. et al. Antitumor effect of vitamin B6 and its mechanisms. Biochim Biophys Acta 2003;1647(1—2):127-30. PMID: 12686121.Robertson M.A., Finochietto P., Gamba C.A. Nicotinamide increases thyroid radiosensitivity by stimulating nitric oxide synthase expression and the generation of organic peroxides. Horm Metab Res 2006;38(1):12-5. DOI: 10.1055/s-2006-924966. PMID: 16477534.Petrovic V., Nepal A., Olaisen C. et al. Anti-cancer potential of homemade fresh garlic extract is related to increased endoplasmic reticulum stress. Nutrients 2018;10(4):450. DOI: 10.3390/nu10040450. PMID: 29621132.Nishikawa-Ogawa M., Wanibuchi H., Morimura K. et al. N-acetylcysteine and S-methylcysteine inhibit MeIQx rat hepatocarcinogenesis in the post-initiation stage. Carcinogenesis 2005;27(5):982-8. DOI: 10.1093/carcin/bgi277. PMID: 16338951.Ansari F.A., Khan A.A., Mahmood R. Protective effect of carnosine and N-acetylcysteine against sodium nitrite-induced oxidative stress and DNA damage in rat intestine. Environ Sci Pollut Res Int 2018;25(20):19380-92. DOI: 10.1007/s11356-018-2133-9. PMID: 29728968.Bruns H., Kazanavicius D., Schultze D. et al. Glycine inhibits angiogenesis in colorectal cancer: role of endothelial cells. Amino Acids 2016;48(11):2549-58. DOI: 10.1007/s00726-016-2278-0. PMID: 27351202.Weinberg J.M., Bienholz A., Venkatachalam M.A. The role of glycine in regulated cell death. Cell Mol Life Sci 2016;73(11 —12):2285-308. DOI: 10.1007/s00018-016-2201-6. PMID: 27066896.Weinberg J.M., Bienholz A., Venkatachalam M.A. The role of glycine in regulated cell death. Cell Mol Life Sci 2016;73(11-12):2285-308. DOI: 10.1007/s00018-016-2201-6. PMID: 27066896.Rose M.L., Cattley R.C., Dunn C. et al. Dietary glycine prevents the development of liver tumors caused by the peroxisome proliferator WY-14,643. Carcinogenesis 1999;20(11):2075-81. PMID: 10545408.Amin K., Li J., Chao W.R. et al. Dietary glycine inhibits angiogenesis during wound healing and tumor growth. Cancer Biol Ther 2003;2(2):173-8. PMID: 12750558.Maddocks O.D.K., Athineos D., Cheung E.C. et al. Modulating the therapeutic response of tumours to dietary serine and glycine starvation. Nature 2017;544(7650): 372-6. DOI: 10.1038/nature22056. PMID: 28425994.Lijima K., Shimosegawa T. Involvement of luminal nitric oxide in the pathogenesis of the gastroesophageal reflux disease spectrum. J Gastroenter Hepatol 2014;29:898-905. DOI: 10.1111/jgh.12548. PMID: 24863184.Kumagai H., Mukaisho K., Sugihara H. et al. Thioproline inhibits development of esophageal adenocarcinoma induced by gastroduodenal reflux in rats. Carcinogenesis 2004;25(5):723-7. DOI: 10.1093/carcin/bgh067. PMID: 14754873.Oyagbemi A.A., Saba A.B., Ibraheem A.O. Curcumin: from Food Spice to cancer prevention. Asian Pacific J Cancer Prev 2009;10:963-7. PMID: 20192567.Siddapa G., Kulsum S., Ravindra D.R. et al. Curcumin and metformin mediated chemoprevention of oral cancer is associated with inhibition of cancer stem cells. Mol Carcinog 2017;56(11):2446-60. DOI: 10.1002/mc.22692. PMID: 28618017.Belitsky G.A., Kirsanov K.I., Lesovaya E.A., Yakubovskaya M.G. Natural inhibitors of carcinogenesis. In: Molecular carcinogenesis. Moscow: ABV-press, 2016. Pp. 158-177. (In Russ.).Белицкий Г.А., Кирсанов К.И., Лесовая Е.А., Якубовская М.Г. Природные ингибиторы канцерогенеза. Молекулярный канцерогенез. М.: АБВ-пресс, 2016. С. 158-177.Cherdantseva L.A., Potapova O.V., Scarcova T.V. et al. Association of Helicobacter pylori and iNOS production by JMJ macrophages and lymphocytes in the gastric mucosa in chronic gastritis. J Immunol Res 2014;2014:762514. DOI: 10.1155/2014/762514. PMID: 25309933.Itzkowitz S.H., Yio X. Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation. Am J Physiol Gastrointest Liver Physiol 2004;287:G7-17. DOI: 10.1152/ajpgi.00079.2004. PMID: 15194558.Hussain S.P., He P., Subleski J. et al. Nitric oxide is a key component in inflammation-accelerated tumorigenesis. Cancer Res 2008;68(17):7130-6. DOI: 10.1158/0008-5472.CAN-08-0410. PMID: 18757428.Roxburgh C.S.D., McMillan D.C. Cancer and systemic inflammation: treat the tumor and treat the host. Br J Cancer 2014;110(6):1409-12. DOI: 10.1038/bjc.2014.90. PMID: 24548867.Vahora H., Khan M.A., Alalami U., Hussain A. The potential role of nitric oxide in halting cancer progression through chemoprevention. J Cancer Prevention 2016;21:1-12. DOI: 10.15430/JCP.2016.21.1.1. PMID: 27051643.Kleinert H., Euchenhofer C., Ihrig-Biedert I., Forstermann U. Glucoco-rticoids inhibits the induction of nitric oxide synthase II by down-regulating cytokine-induced activity of transcription factor nuclear factor-kappa B. Mol Pharmacol 1996;49:15-21. PMID: 8569701.Tedeschi E., Menegazzi M., Margotto D. et al. Anti-inflammatory actions of St. John’s wort: inhibition of human inducible nitric-oxide synthase expression by down¬regulating signal transducer and activator of transcription-1alpha (STAT-1alpha) activation. J Pharmacol Exp Ther 2003;307(1):254-61. DOI: 10.1124/jpet.103.054460. PMID: 12954801.Tedeschi E., Menegazzi M., Margotto D. et al. Anti-inflammatory actions of St. John’s wort: inhibition of human inducible nitric-oxide synthase expression by down-regulating signal transducer and activator of transcription-1alpha (STAT-1alpha) activation. J Pharmacol Exp Ther 2003;307(1):254-61. DOI: 10.1124/jpet.103.054460. PMID: 12954801.Galati G., O’Brien P. Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties. Free Radic Biol Med 2004;37:287-303. DOI: 10.1016/j.freeradbiomed.2004.04.034. PMID: 15223063.Suresh D. Srinivasan K. Tissue distribution & elimination of capsaicin, piperine&curcumin following oral intake in rats. Indian J Med Research 2010;131:682-91. PMID: 20516541.Deryagina V.P., Ryzhova N.I., Golubkina N.A. et al. Experimental study of the preventive properties of plant-enriched selenium products on a model of transplantable tumors in mice. Voprosy biologicheskoy, mrditsinskoy i farmakologicheskoy = Questions of Biological, Medical and Pharmacological chemistry 2011;11:49-55.(In Russ.).Дерягина В.П., Рыжова Н.И., Голубки-на Н.А. и др. Экспериментальное изучение профилактических свойств обогащенных селеном растительных продуктов на модели перевиваемых опухолей у мышей. Вопросы биологи-ческой, медицинской и фармакологической химии 2011;11:49-55.Zhou Y., Zheng J., Li Y. et al. Natural polyphenols for prevention and treatment of cancer. Nutrients 2016;8(8):515. PMID: 27556486. DOI:10.3390/nu808051.Zhou Y., Zheng J., Li Y. et al. Natural polyphenols for prevention and treatment of cancer. Nutrients 2016;8(8):515. PMID: 27556486. DOI: 10.3390/nu808051.Lyashenko A.A., Miroshnichenko I.I., Oganesyan E.A. Increased systemic bioavailability of transresveratrol using nanoparticles. Khimiko-farmatsevticheskii zhurnal = Chemical Pharmaceutical Journal 2010;2:25-8. (In Russ.).Ляшенко А.А., Мирошниченко И.И., Оганесян Е.А. Повышение системной биодоступности трансрезвератрола с использованием наночастиц. Химико-фармацевтический журнал 2010;2:25-8.Khushnud T., Mousa Sh.A. Potential role of naturally derived polyphenols and their nanothechnology delivery in cancer. Mol Biotechnol 2013;55:78-86. DOI: 10.1007/s12033-012-9623-7. PMID: 23371307.Nosrati N., Bacovic M., Paliyath G. Molecular mechanisms and pathways as targets for cancer prevention and progression with dietary compounds. Int J Mol Sci 2017;18(10):2050. DOI: 10.3390/ijms18102050. PMID: 28946660.