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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Advances in Molecular Oncology</journal-id><journal-title-group><journal-title xml:lang="en">Advances in Molecular Oncology</journal-title><trans-title-group xml:lang="ru"><trans-title>Успехи молекулярной онкологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2313-805X</issn><issn publication-format="electronic">2413-3787</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">206</article-id><article-id pub-id-type="doi">10.17650/2313-805X-2019-6-1-49-56</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>RESEARCH ARTICLES</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ЭКСПЕРИМЕНТАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">The role of АВС transporters in drug resistance to bortezomib in multiple myeloma</article-title><trans-title-group xml:lang="ru"><trans-title>Роль АВС-транспортеров в формировании лекарственной устойчивости к бортезомибу при множественной миеломе</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8839-5881</contrib-id><name-alternatives><name xml:lang="en"><surname>Laletina</surname><given-names>L. A.</given-names></name><name xml:lang="ru"><surname>Лалетина</surname><given-names>Л. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>24 Kashirskoe Shosse, Moscow 115478.</p></bio><bio xml:lang="ru"><p>Лалетина Лидия Александровна.</p><p>115478 Москва, Каширское шоссе, 24.</p></bio><email>panlidia@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6697-7154</contrib-id><name-alternatives><name xml:lang="en"><surname>Moiseeva</surname><given-names>N. I.</given-names></name><name xml:lang="ru"><surname>Моисеева</surname><given-names>Н. И.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>24 Kashirskoe Shosse, Moscow 115478.</p></bio><bio xml:lang="ru"><p>115478 Москва, Каширское шоссе, 24.</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6241-1866</contrib-id><name-alternatives><name xml:lang="en"><surname>Klimova</surname><given-names>D. A.</given-names></name><name xml:lang="ru"><surname>Климова</surname><given-names>Д. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>24 Kashirskoe Shosse, Moscow 115478.</p></bio><bio xml:lang="ru"><p>115478 Москва, Каширское шоссе, 24.</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Stavrovskaya</surname><given-names>A. A.</given-names></name><name xml:lang="ru"><surname>Ставровская</surname><given-names>А. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>24 Kashirskoe Shosse, Moscow 115478.</p></bio><bio xml:lang="ru"><p>115478 Москва, Каширское шоссе, 24.</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Research Institute of Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">НИИ канцерогенеза Национального медицинского исследовательского центра онкологии им. Н.Н. Блохина Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2019-01-15" publication-format="electronic"><day>15</day><month>01</month><year>2019</year></pub-date><volume>6</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>49</fpage><lpage>56</lpage><history><date date-type="received" iso-8601-date="2019-04-28"><day>28</day><month>04</month><year>2019</year></date><date date-type="accepted" iso-8601-date="2019-04-28"><day>28</day><month>04</month><year>2019</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2019, Laletina L.A., Moiseeva N.I., Klimova D.A., Stavrovskaya A.A.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2019, Лалетина Л.А., Моисеева Н.И., Климова Д.А., Ставровская А.А.</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="en">Laletina L.A., Moiseeva N.I., Klimova D.A., Stavrovskaya A.A.</copyright-holder><copyright-holder xml:lang="ru">Лалетина Л.А., Моисеева Н.И., Климова Д.А., Ставровская А.А.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://umo.abvpress.ru/jour/article/view/206">https://umo.abvpress.ru/jour/article/view/206</self-uri><abstract xml:lang="en"><p/></abstract><trans-abstract xml:lang="ru"><p/></trans-abstract><kwd-group xml:lang="en"><kwd>bortezomib</kwd><kwd>multiple myeloma</kwd><kwd>multidrug resistance</kwd><kwd>ABC-transporter</kwd><kwd>YB-1</kwd><kwd>P-glycoprotein</kwd><kwd>MRP1</kwd><kwd>BCRP</kwd><kwd>MVP</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>бортезомиб</kwd><kwd>множественная миелома</kwd><kwd>множественная лекарственная устойчивость</kwd><kwd>АВС-транспортер</kwd><kwd>YB-1</kwd><kwd>Р-гликопротеин</kwd><kwd>MRP1</kwd><kwd>BCRP</kwd><kwd>MVP</kwd></kwd-group><funding-group><funding-statement xml:lang="en">E.Yu. Rybalkina; N.N. Kalitin</funding-statement><funding-statement xml:lang="ru">Е.Ю. Рыбалкина; Н.Н. Калитин</funding-statement></funding-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Bessmaltsev S.S. Multiple myeloma(pathogenesis, clinic, diagnosis, differential diagnosis). Klinicheskaya onkogematologiya = Clinical Oncohematology 2013;6(3):237—57.(In Russ.).</mixed-citation><mixed-citation xml:lang="ru">Бессмельцев С.С. Множественная миелома (патогенез, клиника, диагностика, дифференциальный диагноз). Клиническая онкогематология 2013;6(3):237—57.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><mixed-citation>Moreau P., San Miguel J., Sonneveld P. et al. Multiple myeloma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2017;28(suppl 4):iv52-61. DOI: 10.1093/annonc/mdx096. 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