Advances in Molecular OncologyAdvances in Molecular OncologyУспехи молекулярной онкологии2313-805X2413-3787Publishing House ABV Press21410.17650/2313-805X-2019-6-2-8-20REVIEW ARTICLESОБЗОРНЫЕ СТАТЬИAscitis as a unique microenvironment of tumors in ovarian cancer: interaction with prognosis and chemoresistanceАсцит как микроокружение опухоли при раке яичников: взаимосвязь прогноза и химиорезистентностиhttps://orcid.org/0000-0002-2773-1917VillertA. B.ВиллертА. Б.
Russian Federation

5 Kooperativny Pereulok, Tomsk 634009

634009 Томск, Кооперативный переулок, 5

https://orcid.org/0000-0002-6854-8940KolomietsL. A.КоломиецЛ. А.
Russian Federation

5 Kooperativny Pereulok, Tomsk 634009; 2 Moskovskiy Trakt, Tomsk 634050

634009 Томск, Кооперативный переулок, 5; 634050 Томск, Московский тракт, 2

https://orcid.org/0000-0003-4595-4177YunusovaN. V.ЮнусоваН. В.
Russian Federation

5 Kooperativny Pereulok, Tomsk 634009; 2 Moskovskiy Trakt, Tomsk 634050

634009 Томск, Кооперативный переулок, 5; 634050 Томск, Московский тракт, 2

Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of SciencesНИИ онкологии ФГБНУ «Томский национальный исследовательский медицинский центр РАН»Siberian State Medical University, Ministry of Health of RussiaФГБОУ ВО «Сибирский государственный медицинский университет» Минздрава России15052019628202707201927072019Copyright ©; 2019, Villert A.B., Kolomiets L.A., Yunusova N.V.Copyright ©; 2019, Виллерт А.Б., Коломиец Л.А., Юнусова Н.В.2019Villert A.B., Kolomiets L.A., Yunusova N.V.Виллерт А.Б., Коломиец Л.А., Юнусова Н.В.https://creativecommons.org/licenses/by/4.0https://umo.abvpress.ru/jour/article/view/214

The severe heterogeneity of ovarian carcinomas on the molecular genetic level is associated with the absence of specific markers of chemoresistance. At the same time, ascites is an attractive biomarker detection fluid because it is easily obtained. The review is dedicated to the latest advances in the study of components characteristics of ascitic fluid in terms of their relationship with chemoresistance. Оwn data are submitted regarding the contents of the IFR system parameters (free IGFs, as well as IGFBP-3, IGFBP-4 and PAPP-A) in ascitic fluids and tumor tissue in disseminated ovarian cancer, which show the importance of their study. It is shown that the proteins level of the IGF system substantially depend on the volume of ascitic fluid. Studying the features of ascitic fluid in ovarian cancer is directly related to the prospect of new opportunities for disseminated ovarian cancer treatment.

Выраженная гетерогенность карцином яичника на молекулярно-генетическом уровне сопряжена с отсутствием специфических маркеров химиорезистентности. При этом асцит является привлекательной биологической жидкостью для обнаружения биомаркеров, поскольку она легкодоступна для получения. Данный обзор посвящен последним достижениям в изучении особенностей компонентов асцитической жидкости в аспекте их взаимосвязи с химиорезистентностью. Представлены собственные данные, касающиеся содержания параметров системы IFR (свободных IGFs, а также IGFBP-3, IGFBP-4 и PAPP-A) в асцитической жидкости и опухолевой ткани при диссеминированном раке яичников, которые свидетельствуют о значимости их изучения. Показано, что уровень белков системы IGF существенно зависит от объема асцитической жидкости. Изучение особенностей асцитической жидкости при раке яичников напрямую связано с перспективой появления новых возможностей для терапии диссеминированного рака яичников.

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