Advances in Molecular OncologyAdvances in Molecular OncologyУспехи молекулярной онкологии2313-805X2413-3787Publishing House ABV Press21610.17650/2313-805X-2019-6-2-28-41REVIEW ARTICLESОБЗОРНЫЕ СТАТЬИPromises of targeted therapy for low grade gliomas in childrenПерспективы таргетной терапии глиом низкой степени злокачественности у детейhttps://orcid.org/0000-0002-2977-665XValiakhmetovaE. F.ВалиахметоваЭ. Ф.
Russian Federation

16, 4th Tverskaya-Yamskaya St., Moscow 125047

125047 Москва, ул. 4-я Тверская-Ямская, 16

andgeval@gmail.comhttps://orcid.org/0000-0003-3007-3772YaskoL. A.ЯськоЛ. А.
Russian Federation

1 Samory Mashela St., Moscow 117997

117997 Москва, ГСП-7, ул. Саморы Машела, 1

https://orcid.org/0000-0001-7750-5216PapushaL. I.ПапушаЛ. И.
Russian Federation

1 Samory Mashela St., Moscow 117997

117997 Москва, ГСП-7, ул. Саморы Машела, 1

https://orcid.org/0000-0003-1308-8622DruyA. E.ДруйА. Е.
Russian Federation

1 Samory Mashela St., Moscow 117997

117997 Москва, ГСП-7, ул. Саморы Машела, 1

KarachunskyA. I.КарачунскийА. И.
Russian Federation

1 Samory Mashela St., Moscow 117997;  1 Ostrovitianova St., Moscow 117997

117997 Москва, ГСП-7, ул. Саморы Машела, 1; 117997 Москва, ул. Островитянова, 1

N.N. Burdenko National Scientific and Practical Center for Neurosurgery , Ministry of Health of RussiaФГАУ «Национальный медицинский исследовательский центр нейрохирургии им. акад. Н. Н. Бурденко» Минздрава РоссииDmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and ImmunologyФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава РоссииN.I. Pirogov Russian National Research Medical UniversityФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н. И. Пирогова» Минздрава России150520196228412707201927072019Copyright ©; 2019, Valiakhmetova E.F., Yasko L.A., Papusha L.I., Druy A.E., Karachunsky A.I.Copyright ©; 2019, Валиахметова Э.Ф., Ясько Л.А., Папуша Л.И., Друй А.Е., Карачунский А.И.2019Valiakhmetova E.F., Yasko L.A., Papusha L.I., Druy A.E., Karachunsky A.I.Валиахметова Э.Ф., Ясько Л.А., Папуша Л.И., Друй А.Е., Карачунский А.И.https://creativecommons.org/licenses/by/4.0https://umo.abvpress.ru/jour/article/view/216

Low grade gliomas are the most common brain tumors in children. Total resection for operable lesion helps to achieve local and system control. Nevertheless, for inaccessible tumors are required more effective treatment both to overcome the refractory course of the disease, and to mi nimize toxicity with conventional adjuvant chemotherapy and various types of radiation therapy. In recent years, there has been an accelerated understanding of the molecular pathogenesis of some tumors in children, including low grade gliomas. Given the fact that the basis of the molecular pathogenesis of the low grade gliomas is the activation of signaling pathways MARK (mitogen activated protein kinase) and mTOR (mammalian target of rapamycin), the most promising targeted agents are BRAF, MEK and mTOR inhibitors. Nevertheless, a number of other agents have been studied to find promising targeted therapy for this tumors type. This article summarizes the latest literature evaluating new drugs in low grade glioma.

Глиомы низкой степени злокачественности являются преобладающим большинством в структуре опухолей головного мозга у детей. Достичь локального и системного контроля над опухолью возможно при полном удалении образования. Сложная локализация глубоко расположенных и диффузно растущих опухолей ограничивает объем оперативного вмешательства и требует поиска, а также совершенствования методов консервативного лечения данной нозологической группы. Необходимы более эффективные виды лечения как для преодоления рефрактерного течения заболевания, так и для минимизации токсичности, связанной с обычной адъювантной химиотерапией и различными видами лучевой терапии. С учетом того, что в основе молекулярного патогенеза большинства глиом низкой степени злокачественности лежит активация сигнальных путей МАРК (mitogen activated protein kinase) и mTOR (мишени рапамицина млекопитающих), наиболее перспективными агентами – таргетными препаратами являются BRAF, MEK и mTOR-ингибиторы. Тем не менее целый ряд других соединений был исследован в целях поиска перспективных агентов для таргетной терапии при опухолях указанного типа. Обзор суммирует новейшие данные литературы, посвященной новым препаратам при глиоме низкой степени злокачественности.

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