Advances in Molecular OncologyAdvances in Molecular OncologyУспехи молекулярной онкологии2313-805X2413-3787Publishing House ABV Press28410.17650/2313-805X-2020-7-3-27-36REVIEW ARTICLESОБЗОРНЫЕ СТАТЬИMolecular portrait of stomach cancer associated with the Epstein–Barr virusМолекулярный портрет рака желудка, ассоциированного с вирусом Эпштейна–Баррhttps://orcid.org/0000-0002-8114-7885IgnatovaE. O.ИгнатоваЕ. О.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478, Russia

Россия, 115478 Москва, Каширское шоссе, 24

https://orcid.org/0000-0003-3884-9256SeryakD. A.СерякД. А.
Russian Federation

Build. 1, 19 Bol’shaya Pirogovskaya St., Moscow 119146, Russia

Россия, 119146 Москва, Большая Пироговская ул., 19, стр. 1

https://orcid.org/0000-0001-5615-7806FedyaninM. Yu.ФедянинМ. Ю.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478, Russia

Россия, 115478 Москва, Каширское шоссе, 24

https://orcid.org/0000-0003-2245-214XTryakinA. A.ТрякинА. А.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478, Russia

Россия, 115478 Москва, Каширское шоссе, 24

https://orcid.org/0000-0001-9864-3837PokataevI. A.ПокатаевИ. А.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478, Russia

Россия, 115478 Москва, Каширское шоссе, 24

MenshikovaS. F.МеньшиковаС. Ф.
Russian Federation

10 Testovskaya St., Moscow 123112, Russia

Россия, 123112 Москва, Тестовская ул., 10

https://orcid.org/0000-0002-2209-4410VakhabovaYu. V.ВахабоваЮ. В.
Russian Federation

3 2nd Botkinskiy Proezd, Moscow 125284, Russia

Россия, 125284 Москва, 2‑й Боткинский проезд, 3

https://orcid.org/0000-0001-5969-3874KarbyshevM. S.КарбышевМ. С.
Russian Federation

1 Ostrovityanova St., Moscow 117997, Russia

Россия, 117997 Москва, ул. Островитянова, 1

https://orcid.org/0000-0001-6209-977XSmirnovaK. V.СмирноваК. В.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478, Russia

1 Ostrovityanova St., Moscow 117997, Russia

Ксения Валерьевна Смирнова

Россия, 115478 Москва, Каширское шоссе, 24

Россия, 117997 Москва, ул. Островитянова, 1

skv.lab@yandex.ruhttps://orcid.org/0000-0001-9807-2229TulyandinS. A.ТюляндинС. А.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478, Russia

Россия, 115478 Москва, Каширское шоссе, 24

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaФГБУ «Национальный медицинский исследовательский центр онкологии им. Н. Н. Блохина» Минздрава РоссииI.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of RussiaФГАОУ ВО Первый Московский государственный медицинский университет им. И. М. Сеченова (Сеченовский Университет) Минздрава РоссииAnticancer Therapies Department, K 31 CityОтделение противоопухолевой лекарственной терапии АО «К 31 Сити»P.A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Center, Ministry of Health of RussiaМосковский научно-исследовательский онкологический институт им. П. А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава РоссииN.I. Pirogov Russian National Research Medical University, Ministry of Health of RussiaФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н. И. Пирогова» Минздрава России150920207327362311202023112020Copyright ©; 2020, Ignatova E.O., Seryak D.A., Fedyanin M.Y., Tryakin A.A., Pokataev I.A., Menshikova S.F., Vakhabova Y.V., Karbyshev M.S., Smirnova K.V., Tulyandin S.A.Copyright ©; 2020, Игнатова Е.О., Серяк Д.А., Федянин М.Ю., Трякин А.А., Покатаев И.А., Меньшикова С.Ф., Вахабова Ю.В., Карбышев М.С., Смирнова К.В., Тюляндин С.А.2020Ignatova E.O., Seryak D.A., Fedyanin M.Y., Tryakin A.A., Pokataev I.A., Menshikova S.F., Vakhabova Y.V., Karbyshev M.S., Smirnova K.V., Tulyandin S.A.Игнатова Е.О., Серяк Д.А., Федянин М.Ю., Трякин А.А., Покатаев И.А., Меньшикова С.Ф., Вахабова Ю.В., Карбышев М.С., Смирнова К.В., Тюляндин С.А.https://creativecommons.org/licenses/by/4.0https://umo.abvpress.ru/jour/article/view/284

Epstein–Barr virus (EBV) associated gastric carcinoma is a special form of gastric adenocarcinoma that arises against the background of clonal growth of EBV-infected epithelial cells of the gastric mucosa. This subtype of tumors has unique genetic and epigenetic features that determine its characteristic phenotype. Determination of the molecular features of EBV-associated gastric cancer made it possible to identify potential targets for drug therapy of this subtype of tumors. The review presents modern data on the epidemiology and pathogenesis of EBVassociated gastric cancer, describes its unique pathomorphological and molecular features. Particular attention is paid to the prognostic role of EBV infection and drug therapy potentially applicable to the treatment of EBV-positive gastric cancer.

Рак желудка, ассоциированный с вирусом Эпштейна–Барр (ВЭБ), – особая форма онкологического заболевания, возникающая в результате клональной пролиферации ВЭБ-инфицированных эпителиоцитов слизистой оболочки желудка. Данный подтип опухолей имеет уникальные генетические и эпигенетические особенности, определяющие его характерный фенотип. Выявление широкого спектра молекулярных особенностей ВЭБ-ассоциированного рака желудка позволяет описать потенциальные мишени, перспективные для лекарственной терапии данного подтипа опухолей. В обзоре представлены современные данные об эпидемиологии и патогенезе ВЭБ-ассоциированного рака желудка, описаны его уникальные патоморфологические и молекулярные особенности. Особое внимание уделено прогностической роли ВЭБ-инфекции и лекарственной терапии, потенциально применимой для лечения ВЭБ-положительного рака желудка.

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