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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Advances in Molecular Oncology</journal-id><journal-title-group><journal-title xml:lang="en">Advances in Molecular Oncology</journal-title><trans-title-group xml:lang="ru"><trans-title>Успехи молекулярной онкологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2313-805X</issn><issn publication-format="electronic">2413-3787</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">3</article-id><article-id pub-id-type="doi">10.17650/2313-805X.2015.2.1.027-038</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>REVIEW ARTICLES</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОБЗОРНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Prospects of therapeutic action on FGFR signaling pathway</article-title><trans-title-group xml:lang="ru"><trans-title>Перспективы терапевтического воздействия на сигнальный путь FGFR</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Fedyanin</surname><given-names>M. Yu.</given-names></name><name xml:lang="ru"><surname>Федянин</surname><given-names>Михаил Юрьевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>Россия, 115478, Москва, Каширское шоссе, 24</p></bio><email>fedianinmu@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Khmelkova</surname><given-names>D. N.</given-names></name><name xml:lang="ru"><surname>Хмелькова</surname><given-names>Д. Н.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>Лаборатория трансляционных исследований и персонализированной медицины Центра живых систем, Россия, 141700, Московская обл., Долгопрудный, Институтский пер., 9</p></bio><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Serebriyskaya</surname><given-names>T. S.</given-names></name><name xml:lang="ru"><surname>Серебрийская</surname><given-names>Т. С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>Лаборатория трансляционных исследований и персонализированной медицины Центра живых систем, Россия, 141700, Московская обл., Долгопрудный, Институтский пер., 9</p></bio><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Nikolskaya</surname><given-names>T. A.</given-names></name><name xml:lang="ru"><surname>Никольская</surname><given-names>Т. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>Лаборатория трансляционных исследований и персонализированной медицины Центра живых систем, Россия, 141700, Московская обл., Долгопрудный, Институтский пер., 9</p></bio><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Tyulyandin</surname><given-names>S. A.</given-names></name><name xml:lang="ru"><surname>Тюляндин</surname><given-names>С. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>Россия, 115478, Москва, Каширское шоссе, 24</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Department of clinical pharmacology and chemotherapy, N. N. Blokhin Russian Cancer Research Center</institution></aff><aff><institution xml:lang="ru">Отделение клинической фармакологии и химиотерапии ФГБНУ «Российский онкологический научный центр им. Н.Н. Блохина»</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Laboratory of Translational Research and Personalized Medicine, Living Systems Center, Moscow Physical and Technical Institute (State University)</institution></aff><aff><institution xml:lang="ru">ФГАОУ ВПО «Московский физико-технический институт (государственный университет)»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2015-01-15" publication-format="electronic"><day>15</day><month>01</month><year>2015</year></pub-date><volume>2</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>027</fpage><lpage>038</lpage><history><date date-type="received" iso-8601-date="2015-06-02"><day>02</day><month>06</month><year>2015</year></date><date date-type="accepted" iso-8601-date="2015-06-02"><day>02</day><month>06</month><year>2015</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2015, Fedyanin M.Y., Khmelkova D.N., Serebriyskaya T.S., Nikolskaya T.A., Tyulyandin S.A.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2015, Федянин М.Ю., Хмелькова Д.Н., Серебрийская Т.С., Никольская Т.А., Тюляндин С.А.</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="en">Fedyanin M.Y., Khmelkova D.N., Serebriyskaya T.S., Nikolskaya T.A., Tyulyandin S.A.</copyright-holder><copyright-holder xml:lang="ru">Федянин М.Ю., Хмелькова Д.Н., Серебрийская Т.С., Никольская Т.А., Тюляндин С.А.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://umo.abvpress.ru/jour/article/view/3">https://umo.abvpress.ru/jour/article/view/3</self-uri><abstract xml:lang="en"><p/></abstract><trans-abstract xml:lang="ru"><p/></trans-abstract><kwd-group xml:lang="ru"><kwd>фактор роста фибробластов</kwd><kwd>рецепторы к фактору роста фибробластов</kwd><kwd>канцерогенез</kwd><kwd>моноклональные антитела</kwd><kwd>ингибиторы тирозинкиназ</kwd><kwd>клинические исследования</kwd><kwd>солидные опухоли</kwd><kwd>пазопаниб</kwd><kwd>нинтеданиб</kwd><kwd>понатиниб</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. 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