Advances in Molecular OncologyAdvances in Molecular OncologyУспехи молекулярной онкологии2313-805X2413-3787Publishing House ABV Press37910.17650/2313-805X-2021-8-3-44-59REVIEW ARTICLESОБЗОРНЫЕ СТАТЬИLYN kinase and estrogen receptor ERα: involvement in carcinogenesis and potential therapeutic target for tumorsРецептор эстрогенов ERα и киназа LYN: участие в механизмах канцерогенеза и использование в качестве мишеней в таргетной терапии при онкологических заболеванияхhttps://orcid.org/0000-0002-8658-2819TikhonovaV. V.ТихоноваВ. В.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478

115478 Москва, Каширское шоссе, 24

https://orcid.org/0000-0002-6154-535XFinashutinaY. P.ФинашутинаЮ. П.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478

115478 Москва, Каширское шоссе, 24

https://orcid.org/0000-0001-8277-8649KesaevaL. A.КесаеваЛ. А.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478

115478 Москва, Каширское шоссе, 24

N.N. Blokhin Russian Cancer Research Center, Ministry of Health of RussiaФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России150920218344590511202105112021Copyright ©; 2021, Tikhonova V.V., Finashutina Y.P., Kesaeva L.A.Copyright ©; 2021, Тихонова В.В., Финашутина Ю.П., Кесаева Л.А.2021Tikhonova V.V., Finashutina Y.P., Kesaeva L.A.Тихонова В.В., Финашутина Ю.П., Кесаева Л.А.https://creativecommons.org/licenses/by/4.0https://umo.abvpress.ru/jour/article/view/379

Primary or secondary resistance is an important problem when treating any type of tumor. It is often associated with changes in target genes’ functioning. This raises the question of understanding functional intracellular interactions of genes and proteins in oncological processes and therapeutic resistance occurring. When searching target proteins of targeted therapy, it is necessary to identify biomolecules, participating in cell signaling life, which differ significantly in normal and oncological processes and interact with a large number of pathways. It is also important that these biomolecules are not an artifact of tumor therapy or cell line cultivation, and that it is possible to influence them directly, obtaining complex effect. In addition, it is important to study changes occurring during therapy with the biomolecules, which include proto-oncogene of SRC family kinase LYN and gene of the estrogen receptor α ESR1. All these factors may help to overcome the emerging resistance.Objective – to study the way genes of SRC kinase LYN and estrogen receptor α ESR1 influence oncological processes and occurrence of therapeutic resistance.

Важной проблемой при терапии любого типа опухоли является возникновение первичной или вторичной резистентности, которая зачастую связана с изменением функционирования целевых генов. В связи с этим встает вопрос о понимании функциональных внутриклеточных взаимодействий генов и белков в онкологических процессах и возникновении резистентности к лечению. Для поиска целевых белков таргетной терапии необходимо идентифицировать таких участников сигнальной жизни клетки, функциональное состояние которых различно в норме и при канцерогенезе. также важно, чтобы определение этих участников не было артефактом вследствие терапии опухолей или культивирования клеточных линий и существовала возможность оказывать на них прямое воздействие, дающее комплексный эффект. кроме того, необходимо изучить изменения, происходящие с этими участниками, к которым относятся киназы семейства SRC LYN и ген эстрогенового рецептора α, во время терапии в целях преодоления возникающей резистентности.

Цель обзора – изучение роли генов киназы семейства SRC LYN и эстрогенового рецептора α в онкологических процессах и возникновении резистентности к терапии.

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