Advances in Molecular OncologyAdvances in Molecular OncologyУспехи молекулярной онкологии2313-805X2413-3787Publishing House ABV Press38710.17650/2313-805X-2021-8-4-29-41REVIEW ARTICLESОБЗОРНЫЕ СТАТЬИThe mechanism of development of post-traumatic gliomasМеханизм развития посттравматических глиомhttps://orcid.org/0000-0002-4965-0835GareevI. F.ГареевИ. Ф.
Russian Federation

Ilgiz Fanilevich Gareev

5 4th km Chervishevskogo trakta, Tyumen 625032

Ильгиз Фанилевич Гареев

625032 Тюмень, ул. 4-й км Червишевского тракта, 5

ilgiz_gareev@mail.ruhttps://orcid.org/0000-0002-3033-6029FilippovYu. G.ФилипповЮ. Г.
Russian Federation

3 Lenina St., Ufa 450008

450008 Уфа, ул. Ленина, 3

https://orcid.org/0000-0002-6149-5460BeylerliO. A.БейлерлиО. А.
Russian Federation

5 4th km Chervishevskogo trakta, Tyumen 625032

625032 Тюмень, ул. 4-й км Червишевского тракта, 5

https://orcid.org/0000-0001-7580-0385SufianovA. A.СуфиановА. А.
Russian Federation

5 4th km Chervishevskogo trakta, Tyumen 625032Bld. 2, 8 Trubetskaya St., Moscow 119991

625032 Тюмень, ул. 4-й км Червишевского тракта, 5119991 Москва, ул. Трубецкая, 8, стр. 2

TyurinA. V.ТюринА. В.
Russian Federation

132 Dostoevsky St., Ufa 450005

450005 Уфа, ул. Достоевского, 132

MukhametovU. F.МухаметовУ. Ф.
Russian Federation

132 Dostoevsky St., Ufa 450005

450005 Уфа, ул. Достоевского, 132

https://orcid.org/0000-0002-7173-1914YangGuang
China

Harbin 150001, Heilongjiang Province

Харбин 150001, Провинция Хэйлунцзян

https://orcid.org/0000-0002-3486-6246BeylerliA. T.БейлерлиА. Т.
Russian Federation

3 Lenina St., Ufa 450008

450008 Уфа, ул. Ленина, 3

Federal Center of Neurosurgery, Ministry of Health of RussiaФГБУ «Федеральный центр нейрохирургии» Минздрава РоссииBashkir State Medical University, Ministry of Health of RussiaФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава РоссииSechenov First Moscow State Medical University, Ministry of Health of RussiaФГАОУ ВО Первый Московский государственный медицинский университет им. И.М. Сеченова Минздрава РоссииG.G. Kuvatova Republican Clinical HospitalГБУЗ «Республиканская клиническая больница им. Г.Г. Куватова»First Affiliated Hospital of Harbin Medical UniversityПервый аффилированный госпиталь Харбинского медицинского университета151220218429411812202118122021Copyright ©; 2021, Gareev I.F., Filippov Y.G., Beylerli O.A., Sufianov A.A., Tyurin A.V., Mukhametov U.F., Yang G., Beylerli A.T.Copyright ©; 2021, Гареев И.Ф., Филиппов Ю.Г., Бейлерли О.А., Суфианов А.А., Тюрин А.В., Мухаметов У.Ф., Yang G., Бейлерли А.Т.2021Gareev I.F., Filippov Y.G., Beylerli O.A., Sufianov A.A., Tyurin A.V., Mukhametov U.F., Yang G., Beylerli A.T.Гареев И.Ф., Филиппов Ю.Г., Бейлерли О.А., Суфианов А.А., Тюрин А.В., Мухаметов У.Ф., Yang G., Бейлерли А.Т.https://creativecommons.org/licenses/by/4.0https://umo.abvpress.ru/jour/article/view/387

Gliomas are the most common primary tumors of the central nervous system. Their aggressive form – glioblastomas is characterized by an unfavorable prognosis and a high frequency of relapses. It is believed that prior traumatic brain injury is one of the possible factors for the subsequent development of glial brain tumors. Several authors have proposed several criteria for establishing a possible causal relationship between traumatic brain injury and gliomas. However, the actual role of antecedent brain injury in the pathogenesis of this tumor type is still a matter of debate. It has been suggested that traumatic injuries cause an active and prolonged inflammatory process, while disrupting the permeability of the blood-brain barrier, which leads to exposure of the brain tissue to carcinogenic (toxic) substances, various growth factors or cells of the immune system circulating in the bloodstream, which ultimately can lead to malignant transformation of glial cells. One of the evidence for this hypothesis is supported by reports of meningiomas located adjacent to posttraumatic meninges and cerebral scars. In this paper, we will try to elucidate the potential relationship between traumatic brain injury and the formation of glial brain tumors.

Глиомы являются наиболее распространенными первичными опухолями центральной нервной системы. Их агрессивная форма – глиобластомы – характеризуются неблагоприятным прогнозом и высокой частотой рецидивов. Считается, что предшествующая черепно-мозговая травма служит одним из возможных факторов последующего развития глиальных опухолей головного мозга. Ряд авторов предложили критерии установления возможной причинно-следственной связи между черепно-мозговой травмой и глиомами. Однако фактическая роль предшествующей травмы мозга в патогенезе данного типа опухолей все еще остается предметом дискуссий. Было высказано предположение, что травматические повреждения вызывают активный и продолжительный воспалительный процесс. При этом нарушается проницаемость гематоэнцефалического барьера, что приводит к воздействию на ткани головного мозга канцерогенных (токсичных) веществ, различных факторов роста или клеток иммунной системы, циркулирующих в кровотоке. В результате может возникнуть злокачественная трансформация глиальных клеток. Эта гипотеза подтверждается сообщениями о менингиомах головного мозга, расположенных рядом с посттравматическими оболочечно-мозговыми рубцами. В данной работе мы попытаемся выяснить потенциальную связь между черепно-мозговой травмой и формированием глиальных опухолей головного мозга.

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