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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Advances in Molecular Oncology</journal-id><journal-title-group><journal-title xml:lang="en">Advances in Molecular Oncology</journal-title><trans-title-group xml:lang="ru"><trans-title>Успехи молекулярной онкологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2313-805X</issn><issn publication-format="electronic">2413-3787</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">4</article-id><article-id pub-id-type="doi">10.17650/2313-805X.2015.2.1.039-051</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>REVIEW ARTICLES</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОБЗОРНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">News in the studies of multidrug resistance of breast cancer cells</article-title><trans-title-group xml:lang="ru"><trans-title>Новое в изучении множественной лекарственной устойчивости клеток рака молочной железы</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Stavrovskaya</surname><given-names>A. A.</given-names></name><name xml:lang="ru"><surname>Ставровская</surname><given-names>Алла Александровна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>24 Kashirskoye Highway, Moscow, 115478, Russia</p></bio><bio xml:lang="ru"><p>Россия, 115478, Москва, Каширское шоссе, 24</p></bio><email>astavrovskaya@yahoo.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Guens</surname><given-names>G. P.</given-names></name><name xml:lang="ru"><surname>Генс</surname><given-names>Г. П.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Department of Oncology and Radiology, 20 Bldg. 1 Delegatskaya St., Moscow, 127473, Russia</p></bio><bio xml:lang="ru"><p>кафедра онкологии и лучевой терапии, Россия, 127473, Москва, ул. Делегатская, 20, стр. 1</p></bio><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">N.N. Blokhin Russian Cancer Research Center</institution></aff><aff><institution xml:lang="ru">ФГБНУ «РОНЦ им. Н.Н. Блохина»</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">A. I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ГБОУ ВПО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2015-01-15" publication-format="electronic"><day>15</day><month>01</month><year>2015</year></pub-date><volume>2</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>039</fpage><lpage>051</lpage><history><date date-type="received" iso-8601-date="2015-06-02"><day>02</day><month>06</month><year>2015</year></date><date date-type="accepted" iso-8601-date="2015-06-02"><day>02</day><month>06</month><year>2015</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2015, Stavrovskaya A.A., Guens G.P.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2015, Ставровская А.А., Генс Г.П.</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="en">Stavrovskaya A.A., Guens G.P.</copyright-holder><copyright-holder xml:lang="ru">Ставровская А.А., Генс Г.П.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://umo.abvpress.ru/jour/article/view/4">https://umo.abvpress.ru/jour/article/view/4</self-uri><abstract xml:lang="en"><p>Breast cancer (BC) is the most common cancer among women in Russia. One of the main treatment methods of BC is systemic chemotherapy. Multidrug resistance of tumor cells (MDR) is the important hindrance on the way to successful chemotherapy. The new data concerning molecular mechanisms of MDR will be presented in this review. The recent data concerning some new biological prognostic markers will be also discussed. There are data showing that transporters of ABC family (ABC transporters) influence tumor progression not only by MDR induction but also by the influence on the traits of malignancy in tumor cells. The results of the studies of ABC transporters, participation in the processes of accumulation of tumor stem cells under the influence of chemotherapy will be discussed. The problem of the participation of ABC transporters in the phenomenon of influence of PI3K/AKT/PTEN signal transduction pathway on the MDR regulation is discussed. The results of the studies of the role of microRNA deregulation in breast cancer drug resistance as well as studies of some epigenetic mechanisms of MDR regulation will be considered. Protein phosphatase 2A (PP2A, serine/threonine phosphatase), PTK7 (protein tyrosine kinase 7). fascin (an actin bundling cytoskeletal protein) multifunctional YB-1 protein will considered as new BC prognostic markers. The perspectives of MDR studies will be discussed as well.</p></abstract><trans-abstract xml:lang="ru"><p/></trans-abstract><kwd-group xml:lang="en"><kwd>breast cancer</kwd><kwd>tumor progression</kwd><kwd>multidrug resistance</kwd><kwd>biological tumor markers</kwd><kwd>transporters of ABC family</kwd><kwd>tumor stem cells</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>рак молочной железы</kwd><kwd>прогрессия опухолей</kwd><kwd>множественная лекарственная устойчивость</kwd><kwd>биологические маркеры опухоли</kwd><kwd>транспортные белки семейства АВС</kwd><kwd>стволовые клетки опухолей</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Ставровская А.А. Клеточные механизмы множественной лекарственной устойчивости опухолевых клеток (обзор). Биохимия 2000;65(1):112–26. [Stavrovskaya A.A. Cellular mechanisms of multiple drug resistance of malignant cells (review). 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