Advances in Molecular OncologyAdvances in Molecular OncologyУспехи молекулярной онкологии2313-805X2413-3787Publishing House ABV Press4610.17650/2313-805X.2015.2.3.60-62RESEARCH ARTICLESЭКСПЕРИМЕНТАЛЬНЫЕ СТАТЬИSTUDY OF THE RELATIONSHIP BETWEEN CIRCADIAN RHYTHMS AND DRUG RESISTANCE OF BREAST TUMOR CELL LINESИССЛЕДОВАНИЕ ВЗАИМОСВЯЗИ МЕЖДУ ЦИРКАДНЫМ РИТМОМ И ЛЕКАРСТВЕННОЙ УСТОЙЧИВОСТЬЮ НА ПРИМЕРЕ КЛЕТОЧНЫХ ЛИНИЙ РАКА МОЛОЧНОЙ ЖЕЛЕЗЫОgloblinaA. M.ОглоблинаА. М.
Russian Federation
susovaolga@gmail.comRybalkinaE. Yu.РыбалкинаЕ. Ю.
Russian Federation
susovaolga@gmail.comКirsanovK. I.КирсановК. И.
Russian Federation
susovaolga@gmail.comMoiseevaN. I.МоисееваН. И.
Russian Federation
susovaolga@gmail.comКondratovR. V.КондратовР. В.
United States
susovaolga@gmail.comSusovaO. Yu.СусоваО. Ю.
Russian Federation

Сусова Ольга Юрьевна

susovaolga@gmail.comResearch Institute of Carcinogenesis, N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia, MoscowНаучно-исследовательский институт канцерогенеза ФГБУ «Российский онкологический научный центр имени Н.Н. Блохина» Минздрава России, МоскваCleveland State University, ClevelandГосударственный университет Кливленда, Кливленд150920152360621812201518122015Copyright ©; 2015, Оgloblina A.M., Rybalkina E.Y., Кirsanov K.I., Moiseeva N.I., Кondratov R.V., Susova O.Y.Copyright ©; 2015, Оглоблина А.М., Рыбалкина Е.Ю., Кирсанов К.И., Моисеева Н.И., Кондратов Р.В., Сусова О.Ю.2015Оgloblina A.M., Rybalkina E.Y., Кirsanov K.I., Moiseeva N.I., Кondratov R.V., Susova O.Y.Оглоблина А.М., Рыбалкина Е.Ю., Кирсанов К.И., Моисеева Н.И., Кондратов Р.В., Сусова О.Ю.https://creativecommons.org/licenses/by/4.0https://umo.abvpress.ru/jour/article/view/46

10 % of genome mRNA expression is rhythmic and these 24-hrs rhythms are under control of the circadian clock. Epidemiologic studies have revealed a clear link between the disruption of circadian rhythms and cancer development in humans. Growing evidence shows that circadian disruption is associated with development of malignant tumors, including breast cancer. Aim of this study was to investigate: the expression of circadian clock genes in human mammary epithelial cell line MCF10A and breast cancer cell lines MCF-7, ZR-75-1, BT-474 and if the multidrug resistance phenotype of cancer cells is associated with changes in circadian clock genes expression. We have found that Per1 expression significantly reduced in cancer cells. No correlation was detected between the expression of circadian clock genes and cancer breast cell lines drug resistance. Interestingly, the expression of Bmal1, Per1 and Cry1 were increased in multi-drug resistant MCF-7_D cells compare with the parent cells MCF-7 cells, however, if these changes in the expression contribute to the drug-resistance or not is not clear. These results argue for further study.

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