Advances in Molecular OncologyAdvances in Molecular OncologyУспехи молекулярной онкологии2313-805X2413-3787Publishing House ABV Press47310.17650/2313-805X-2022-9-4-8-23REVIEW ARTICLESОБЗОРНЫЕ СТАТЬИMechanisms of the carcinogenicity of nanomaterialsМеханизмы канцерогенного действия наноматериаловBelitskyG. A.БелицкийГ. А.
Russian Federation

24 Kashirskoe Shosse, Moscow 115522

115522 Москва, Каширское шоссе, 24

https://orcid.org/0000-0002-8599-6833KirsanovK. I.КирсановК. И.
Russian Federation

24 Kashirskoe Shosse, Moscow 115522

6 Miklukho-Maklaya St., Moscow 117198

115522 Москва, Каширское шоссе, 24

117198 Москва, ул. Миклухо-Маклая, 6

https://orcid.org/0000-0002-1967-9637LesovayaE. A.ЛесоваяЕ. А.
Russian Federation

24 Kashirskoe Shosse, Moscow 115522

9 Vysokovol’tnaya St., Ryazan 390026

115522 Москва, Каширское шоссе, 24390026 Рязань, ул. Высоковольтная, 9

https://orcid.org/0000-0002-9710-8178YakubovskayaM. G.ЯкубовскаяМ. Г.
Russian Federation

24 Kashirskoe Shosse, Moscow 115522

Марианна Геннадиевна Якубовская

115522 Москва, Каширское шоссе, 24

mgyakubovskaya@mail.ruN.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaФГБУ «Национальный медицинский исследовательский центр онкологии им. Н. Н. Блохина» Минздрава РоссииPeoples’ Friendship University of RussiaФГАОУ ВО «Российский университет дружбы народов»I.P. Pavlov Ryazan State Medical UniversityФГБОУ ВО «Рязанский государственный медицинский университет им. акад. И. П. Павлова»15122022941612202216122022Copyright ©; 2022, Belitsky G.A., Kirsanov K.I., Lesovaya E.A., Yakubovskaya M.G.Copyright ©; 2022, Белицкий Г.А., Кирсанов К.И., Лесовая Е.А., Якубовская М.Г.2022Belitsky G.A., Kirsanov K.I., Lesovaya E.A., Yakubovskaya M.G.Белицкий Г.А., Кирсанов К.И., Лесовая Е.А., Якубовская М.Г.https://creativecommons.org/licenses/by/4.0https://umo.abvpress.ru/jour/article/view/473

Nanomaterials become more widespread in the different areas of human life, forming the new technosphere philosophy, in particular, new approaches for development and usage of these materials in everyday life, manufacture, medicine etc.The physicochemical characteristics of nanomaterials differ significantly from the corresponding indicators of aggregate materials and at least some of them are highly reactive and / or highly catalytic. This suggests their aggressiveness towards biological systems, including involvement in carcinogenesis. The review considers the areas of use of modern nanomaterials, with special attention paid to the description of medicine production using nanotechnologies, an analysis of the mechanisms of action of a number of nanomaterials already recognized as carcinogenic, and also presents the available experimental and mechanistic data obtained from the study of the carcinogenic / procarcinogenic effects of various groups of nanomaterials currently not classified as carcinogenic to humans.Preparing the review, information bases of biomedical literature were analysed: Scopus (307), PubMed (461), Web of Science (268), eLibrary.ru (190) were used. To obtain full-text documents, the electronic resources of PubMed Central (PMC), Science Direct, Research Gate, Sci-Hub and eLibrary.ru databases were used.

Наноматериалы получают все большее распространение во многих областях жизни человека, формируя новую философию техносферы и, в частности, новые подходы к получению и использованию материалов в бытовых процессах, производстве, медицине и пр. Физико-химические характеристики наноматериалов существенно отличаются от соответствующих показателей агрегатных материалов и, по крайней мере, некоторые из них – высокой реакционноспособностью и / или повышенной каталитической активностью. Это позволяет предположить их агрессивность по отношению к биологическим системам, включая участие в процессах канцерогенеза.В обзоре рассмотрены сферы использования современных наноматериалов, при этом особое внимание уделено описанию лекарственных препаратов, произведенных с использованием нанотехнологий, приведен анализ механизмов действия тех из них, которые уже признаны канцерогенными, а также представлены имеющиеся экспериментальные и механистические данные, полученные при изучении канцерогенного / проканцерогенного действия различных групп наноматериалов, не классифицируемых в настоящее время как представляющие канцерогенную опасность для человека.При подготовке обзора был проведен анализ публикаций информационных баз биомедицинской литературы Scopus (507), PubMed (561), Web of Science (268), eLibrary.ru (190). Для получения полнотекстовых документов использованы электронные ресурсы PubMed Central (PMC), Science Direct, Research Gate, базы данных Sci-Hub и eLibrary.ru.

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