Advances in Molecular OncologyAdvances in Molecular OncologyУспехи молекулярной онкологии2313-805X2413-3787Publishing House ABV Press53910.17650/2313-805X-2023-10-2-30-41REVIEWОБЗОРНАЯ СТАТЬЯMechanisms of action of plant polyphenols on the initiation of carcinogenesisМеханизмы действия растительных полифенолов на инициацию канцерогенезаhttps://orcid.org/0000-0003-0768-9309LyubitelevA. V.ЛюбителевА. В.
Russian Federation

Alexander V. Lyubitelev - Department of Bioengineering of Lomonosov Moscow State University.

Bld. 12, 1 Leninskie Gory, Moscow 119234

Любителев Александр Викторович - кафедра биоинженерии ФГБОУ ВО «МГУ им. М.В. Ломоносова».

119234 Москва, Ленинские горы, 1, стр. 12

varanus.storri@gmail.comhttps://orcid.org/0000-0002-4681-0178SivkinaA. L.СивкинаА. Л.
Russian Federation

Department of Bioengineering of Lomonosov Moscow State University.

Bld. 12, 1 Leninskie Gory, Moscow 119234

Кафедра биоинженерии ФГБОУ ВО «МГУ им. М.В. Ломоносова».

119234 Москва, Ленинские горы, 1, стр. 12

https://orcid.org/0000-0002-1498-849XVlasovaO. A.ВласоваО. А.
Russian Federation

24 Kashirskoe Shosse, Moscow 115522

115522 Москва, Каширское шоссе, 24

https://orcid.org/0000-0002-3167-7204BelitskyG. A.БелицкийГ. A.
Russian Federation

24 Kashirskoe Shosse, Moscow 115522

115522 Москва, Каширское шоссе, 24

https://orcid.org/0000-0002-7389-7993StuditskyV. M.СтудитскийВ. М.
Russian Federation

Department of Bioengineering of Lomonosov Moscow State University

Bld. 12, 1 Leninskie Gory, Moscow 119234; 333 Cottman Ave, Philadelphia 19111, Pennsylvania, USA

Кафедра биоинженерии ФГБОУ ВО «МГУ им. М.В. Ломоносова».

119234 Москва, Ленинские горы, 1, стр. 12; 333 Cottman Ave, Philadelphia 19111, Pennsylvania, USA

Lomonosov Moscow State UniversityФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова»N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава РоссииFox Chase Cancer Center1505202310230412311202210072023Copyright ©; 2023, Lyubitelev A.V., Sivkina A.L., Vlasova O.A., Belitsky G.A., Studitsky V.M.Copyright ©; 2023, Любителев А.В., Сивкина А.Л., Власова О.А., Белицкий Г.A., Студитский В.М.2023Lyubitelev A.V., Sivkina A.L., Vlasova O.A., Belitsky G.A., Studitsky V.M.Любителев А.В., Сивкина А.Л., Власова О.А., Белицкий Г.A., Студитский В.М.https://creativecommons.org/licenses/by/4.0https://umo.abvpress.ru/jour/article/view/539

Genetic apparatus of human cells is constantly affected by a broad spectrum of mutagenic factors, both exogenous and endogenous. Genetic and epigenetic disorders, which emerge as a result of this influence, become the main cause of the majority of malignant neoplasias. Several different approaches were proposed to prevent these disorders, including the suppression of the activity of mutagenic factors by treatment with certain chemical compounds. Plant polyphenols are promising candidates for the development of chemopreventive drugs, as they exert the ability to regulate the metabolic activation of procarcinogens and modulate the cellular oxidative stress. In the present review, classification of plant phenolic compounds and their interactions  with biological macromolecules are described, along with the molecular mechanisms of their influence on the enzymes and regulatory pathways of phase I xenobiotic metabolism, and the prevention of oxidative stress. Interactions between natural polyphenols and patient’s microbiota is also described.

Генетический аппарат клеток человеческого организма находится под постоянным воздействием большого спектра генотоксичных и негенотоксичных агентов, как экзогенных, так и эндогенных. возникающие в результате таких воздействий генетические и эпигенетические нарушения являются звеньями молекулярного патогенеза злокачественных новообразований. для профилактики развития таких нарушений предложены несколько различных подходов, включая подавление генотоксичного воздействия с помощью химических соединений. Благодаря способности оказывать влияние на активацию проканцерогенов и регуляцию окислительного стресса, растительные полифенольные соединения являются одними из перспективных кандидатов на роль химиопрофилактических антиканцерогенных препаратов. в обзоре рассмотрены структура и классификация полифенольных соединений и механизмы их взаимодействия с биологическими макромолекулами, а также молекулярные механизмы их влияния на ферменты, участвующие в 1-й фазе активации ксенобиотиков и регуляции окислительного стресса. Также проведен анализ эффектов природных полифенолов на микрофлору человека.

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