Advances in Molecular OncologyAdvances in Molecular OncologyУспехи молекулярной онкологии2313-805X2413-3787Publishing House ABV Press54010.17650/2313-805X-2023-10-2-42-57REVIEWОБЗОРНАЯ СТАТЬЯMolecular genetic aspects of adrenocortical cancerМолекулярно-генетические аспекты адренокортикального ракаhttps://orcid.org/0000-0003-2746-8837YashinaD. P.ЯшинаД. П.
Russian Federation

Darya P. Yashina - Department of Oncology, Radiology and Palliative Medicine, Kazan State Medical Academy – branch of the Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia.

36 Butlerova St., Kazan 420012, Republic of Tatarstan; 29 Sibirskii Tract, Kazan 420029, Republic of Tatarstan

Яшина Дарья Петровна - кафедра онкологии, радиологии и паллиативной медицины КГМА – филиала ФГБОУ ДПО «РМАНПО» Минздрава России.

Республика Татарстан, 420012 Казань, ул. Бутлерова, 36; Республика Татарстан, 420029 Казань, ул. Сибирский тракт, 29

darya.nikulina.94@list.ruhttps://orcid.org/0000-0002-6187-2983AfanasyevaZ. A.АфанасьеваЗ. А.
Russian Federation

Department of Oncology, Radiology and Palliative Medicine, Kazan State Medical Academy – branch of the Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia.

36 Butlerova St., Kazan 420012, Republic of Tatarstan; 29 Sibirskii Tract, Kazan 420029, Republic of Tatarstan

Кафедра онкологии, радиологии и паллиативной медицины КГМА – филиала ФГБОУ ДПО «РМАНПО» Минздрава России.

Республика Татарстан, 420012 Казань, ул. Бутлерова, 36; Республика Татарстан, 420029 Казань, ул. Сибирский тракт, 29

Kazan State Medical Academy – branch of the Russian Medical Academy of Continuing Professional Education, Ministry of Health of RussiaКазанская государственная медицинская академия – филиал ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииRepublican Clinical Oncological Dispansary, Ministry of Health of Republic of TatarstanГАУЗ «Республиканский клинический онкологический диспансер» Минздрава Республики Татарстан1505202310242571101202310072023Copyright ©; 2023, Yashina D.P., Afanasyeva Z.A.Copyright ©; 2023, Яшина Д.П., Афанасьева З.А.2023Yashina D.P., Afanasyeva Z.A.Яшина Д.П., Афанасьева З.А.https://creativecommons.org/licenses/by/4.0https://umo.abvpress.ru/jour/article/view/540

Adrenocortical cancer is a rare tumor originating from cortical adrenal cells, endowed with aggressive potential, a rapidly progressing course and an unfavorable prognosis. The complexity of early diagnosis of the disease is due to several factors: the variability of clinical manifestations associated with the initial multiregulatory influence of steroid hormones on the body’s homeostasis, the rare occurrence of the tumor and, as a result, the lack of understanding of the molecular mechanisms of its carcinogenesis.

The increased interest in recent years among oncologists and endocrinologists in understanding the fundamental and clinical aspects of adrenocortical cancer and the search for potential targets for new drugs has led to a detailed study of the cellular and molecular genetic mechanisms involved in normal adrenal ontogenesis and their role in tumor transformation. This review presents the currently known molecular genetic processes and their mediating auto-, para-, endocrine factors involved in normal adrenal ontogenesis and carcinogenesis. The paper analyzes results of trials published in international and Russian journals on molecular oncology and endocrinology indexed in the PubMed, CyberLeninka, Web of Science, Science Direct and eLIBRARY databases.

Адренокортикальный рак – редко встречаемая опухоль, происходящая из кортикальных клеток надпочечников, характеризующаяся агрессивным потенциалом, быстро прогрессирующим течением и неблагоприятным прогнозом. Сложность ранней диагностики заболевания обусловлена несколькими факторами: вариабельностью клинических проявлений, связанной с изначальным мультирегуляторным влиянием стероидных гормонов на гомеостаз организма, а также редкостью опухоли и, как следствие, малоизученностью молекулярных механизмов ее канцерогенеза. возросший за последние годы интерес онкологов и эндокринологов к пониманию фундаментальных и клинических аспектов адренокортикального рака и поиск потенциальных мишеней для новых лекарственных препаратов привели к детальному изучению клеточных и молекулярно-генетических  механизмов, участвующих в нормальном онтогенезе надпочечников, и их роли в опухолевой трансформации. в данном обзоре представлены известные на настоящий момент молекулярно-генетические  процессы и опосредующие их ауто-, пара- и эндокринные факторы, задействованные в нормальном надпочечниковом онтогенезе и канцерогенезе. в работе проанализированы результаты исследований, опубликованных в зарубежных и отечественных журналах по молекулярной онкологии и эндокринологии, представленных в базах данных PubMed, CyberLeninka,  Web of Science, Science Direct и eLIBRARY.

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