Advances in Molecular OncologyAdvances in Molecular OncologyУспехи молекулярной онкологии2313-805X2413-3787Publishing House ABV Press56410.17650/2313-805X-2023-10-3-8-14REVIEW ARTICLESОБЗОРНЫЕ СТАТЬИCurrent approaches to systemic treatment of BRCA-associated triple-negative breast cancerСовременные подходы к системному лечению BRCA-ассоциированного трижды негативного рака молочной железыhttps://orcid.org/0000-0002-2773-3111EnaldievaD. A.ЕналдиеваД. А.
Russian Federation

68 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg 197758,

197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68

dianaenaldieva932@gmail.comhttps://orcid.org/0000-0002-4898-9159KrivorotkoP. V.КриворотькоП. В.
Russian Federation

68 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg 197758,

197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68

https://orcid.org/0000-0003-4529-7891ImyanitovE. N.ИмянитовЕ. Н.
Russian Federation

68 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg 197758,

197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68

https://orcid.org/0000-0002-2029-4582ZhiltsovaE. K.ЖильцоваЕ. К.
Russian Federation

68 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg 197758,

197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68

https://orcid.org/0000-0002-9391-5327DonskikhR. V.ДонскихР. В.
Russian Federation

68 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg 197758,

197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68

https://orcid.org/0000-0001-9623-3877ShaikhelislamovaL. F.ШайхелисламоваЛ. Ф.
Russian Federation

68 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg 197758,

197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68

https://orcid.org/0000-0001-7654-4336GigolaevaL. P.ГиголаеваЛ. П.
Russian Federation

68 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg 197758,

197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68

https://orcid.org/0000-0003-0077-9619SemiglazovV. F.СемиглазовВ. Ф.
Russian Federation

68 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg 197758,

197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68

N. N. Petrov National Medical Research Centre of Oncology, Ministry of Health of RussiaФГБУ «Национальный медицинский исследовательский центр онкологии им. Н. Н. Петрова» Минздрава России150920231038140710202307102023Copyright ©; 2023, Enaldieva D.A., Krivorotko P.V., Imyanitov E.N., Zhiltsova E.K., Donskikh R.V., Shaikhelislamova L.F., Gigolaeva L.P., Semiglazov V.F.Copyright ©; 2023, Еналдиева Д.А., Криворотько П.В., Имянитов Е.Н., Жильцова Е.К., Донских Р.В., Шайхелисламова Л.Ф., Гиголаева Л.П., Семиглазов В.Ф.2023Enaldieva D.A., Krivorotko P.V., Imyanitov E.N., Zhiltsova E.K., Donskikh R.V., Shaikhelislamova L.F., Gigolaeva L.P., Semiglazov V.F.Еналдиева Д.А., Криворотько П.В., Имянитов Е.Н., Жильцова Е.К., Донских Р.В., Шайхелисламова Л.Ф., Гиголаева Л.П., Семиглазов В.Ф.https://creativecommons.org/licenses/by/4.0https://umo.abvpress.ru/jour/article/view/564

BRCA-associated triple-negative breast cancer (TNBC) is characterized by high sensitivity to DNA-damaging cytotoxic drugs. The use of well-known BRCA1/2-specific antitumor agents – platinum derivatives and PARP inhibitors – has been discussed for a long time in the context of the treatment of metastatic BRCA-associated TNBC. Neoadjuvant regimens based on the use of anthracyclines and taxanes are the standard of drug therapy for primary BRCA-associated breast cancer. At present, there are few data regarding the addition of platinum drugs to anthracycline-taxane neoadjuvant chemotherapy in the treatment of primary BRCA-associated TNBC. This review details the various treatment options for both primary and metastatic BRCA-associated TNBC. It has been shown that the development of new strategies for the neoadjuvant chemotherapy of patients with primary BRCA-associated TNBC is an urgent clinical need to reduce the risks of recurrence and progression.

BRCA-ассоциированный трижды негативный рак молочной железы (ТНРМЖ) характеризуется высокой чувствительностью к ДНК-повреждающим цитотоксическим препаратам. Применение известных BRCA1/2-специфических противоопухолевых средств – производных платины и PARP-ингибиторов – длительное время обсуждалось в контексте лечения метастатического BRCA-ассоциированного ТНРМЖ. Стандартом лекарственной терапии первичного BRCA-ассоциированного РМЖ является неоадъювантная химиотерапия с использованием антрациклинов и таксанов. В настоящее время имеется не так много данных о добавлении препаратов платины к антрациклин-таксановой неоадъювантной химиотерапии при лечении первичного BRCA-ассоциированного ТНРМЖ. В представленном обзоре подробно описаны различные способы терапии данного рака, как первичного, так и метастатического. Показано, что разработка новых стратегий неоадъювантной химиотерапии для пациенток с первичным BRCA-ассоциированным ТНРМЖ является насущной клинической необходимостью для снижения рисков рецидивирования и прогрессирования.

BRCA1/2 mutationsneoadjuvant chemotherapypathological complete responsetriple-negative breast cancermetastatic breast canceмутации BRCA1/2неоадъювантная химиотерапияпатологический полный ответтрижды негативный рак молочной железыметастатический рак молочной железыThis study was supported by the Russian Science Foundation (grand No. 22-15-0266).Работа выполнена при поддержке Российского научного фонда (гранд № 22-15-0266).Malignant neoplasms in Russia in 2021 (morbidity and mortality). Moscow: P.A. Herzen Institute of Medical Research – branch of the Federal State Budgetary Institution “NMIC of Radiology” of the Ministry of Health of Russia, 2022. 252 p. (In Russ.).Злокачественные новообразования в России в 2021 году (заболеваемость и смертность). Под ред. А.Д. Каприна, В.В. Старигородского, А.О. Шахзадовой. М.: МНИОИ им. П.А. Герцена – филиал ФГБУ «НМИЦ радиологии» Минздрава России, 2022. 252 с.Desai N.V., Tung N.M. 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