Advances in Molecular OncologyAdvances in Molecular OncologyУспехи молекулярной онкологии2313-805X2413-3787Publishing House ABV Press56910.17650/2313-805X-2023-10-3-36-49REVIEW ARTICLESОБЗОРНЫЕ СТАТЬИThe role of mycoplasmas as an infectious agent in carcinogenesisРоль микоплазм в качестве инфекционного агента при канцерогенезеhttps://orcid.org/0000-0002-3216-4320GalyaminaM. A.ГаляминаМ. А.
Russian Federation

1a Malaya Pirogovskaya St., Moscow 119435

119435 Москва, ул. Малая Пироговская, 1а

mrogova@gmail.comhttps://orcid.org/0000-0001-5265-7627PobegutsO. V.ПобегуцО. В.
Russian Federation

1a Malaya Pirogovskaya St., Moscow 119435

119435 Москва, ул. Малая Пироговская, 1а

https://orcid.org/0000-0002-2743-5835GorbachevA. Yu.ГорбачевА. Ю.
Russian Federation

1a Malaya Pirogovskaya St., Moscow 119435

119435 Москва, ул. Малая Пироговская, 1а

Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological AgencyФГБУ «Федеральный научно-клинический центр физико-химической медицины им. акад. Ю. М. Лопухина Федерального медико-биологического агентства»1509202310336490910202309102023Copyright ©; 2023, Galyamina M.A., Pobeguts O.V., Gorbachev A.Y.Copyright ©; 2023, Галямина М.А., Побегуц О.В., Горбачев А.Ю.2023Galyamina M.A., Pobeguts O.V., Gorbachev A.Y.Галямина М.А., Побегуц О.В., Горбачев А.Ю.https://creativecommons.org/licenses/by/4.0https://umo.abvpress.ru/jour/article/view/569

The review presents data on studies of the role of mycoplasmas as infectious agents in carcinogenesis, as well as their participation in cancer drug therapy and the impact on the outcome of treatment. Mycoplasmas are of particular interest because they have unique abilities to readily attach to and enter eukaryotic cells, modulate their functional state, and induce chronic inflammation while evading the host’s immune system. The review will highlight the data confirming the increased colonization of tumor tissue by mycoplasmas compared to healthy ones, describe the molecular mechanisms by which mycoplasmas activate the expression of oncogenes and growth factors, inactivate tumor suppressors, promote NF-κB-dependent migration of cancer cells and modulate apoptosis, which results in abnormal growth and transformation of host cells. The review also presents data on the effectiveness of anticancer drugs in mycoplasmal infections.

В обзоре представлены данные исследований о роли микоплазм в качестве инфекционных агентов при канцерогенезе, а также их участии в медикаментозной терапии рака и влиянии на исход лечения. Микоплазмы представляют особый интерес, поскольку обладают уникальными способностями легко прикрепляться к эукариотическим клеткам и проникать в них, модулировать их функциональное состояние и вызывать хроническое воспаление, избегая действия иммунной системы хозяина. В обзоре представлены данные, подтверждающие повышенную колонизацию микоплазмами опухолевой ткани по сравнению со здоровой, описаны молекулярные механизмы, с помощью которых микоплазмы активируют экспрессию онкогенов и факторов роста, инактивируют супрессоры опухоли, способствуют NF-κB-зависимой миграции опухолевых клеток и модулируют апоптоз, что приводит к аномальному росту и трансформации клеток хозяина. Также анализируется эффективность противоопухолевых препаратов при микоплазменной инфекции.

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