Advances in Molecular OncologyAdvances in Molecular OncologyУспехи молекулярной онкологии2313-805X2413-3787Publishing House ABV Press60410.17650/2313-805X-2023-10-4-8-20REVIEWОБЗОРНАЯ СТАТЬЯCellular microenvironment as an object of targeted therapy for malignant neoplasmsКлеточное микроокружение как объект таргетной терапии злокачественных новообразованийhttps://orcid.org/0000-0001-8216-4196ZyablitskayaE. Yu.ЗяблицкаяЕ. Ю.
Russian Federation

Evgenia Yu. Zyablitskaya.

Bld. 7, 5 Lenin Boulevard, Simferopol 295051

Зяблицкая Евгения Юрьевна.

295051 Симферополь, бульвар Ленина, 5, стр. 7

evgu79@mail.ruhttps://orcid.org/0000-0002-9400-1826KubyshkinA. V.КубышкинА. В.
Russian Federation

Bld. 7, 5 Lenin Boulevard, Simferopol 295051

295051 Симферополь, бульвар Ленина, 5, стр. 7

https://orcid.org/0000-0002-1862-6816SorokinaL.  E.СорокинаЛ. Е.
Russian Federation

Bld. 7, 5 Lenin Boulevard, Simferopol 295051

295051 Симферополь, бульвар Ленина, 5, стр. 7

https://orcid.org/0000-0002-1048-5158SerebryakovaA. V.СеребряковаА. В.
Russian Federation

Bld. 7, 5 Lenin Boulevard, Simferopol 295051

295051 Симферополь, бульвар Ленина, 5, стр. 7

https://orcid.org/0000-0003-3911-1245AlievK.  A.АлиевК. А.
Russian Federation

Bld. 7, 5 Lenin Boulevard, Simferopol 295051

295051 Симферополь, бульвар Ленина, 5, стр. 7

https://orcid.org/0000-0001-5920-8664MaksimovaP.  E. МаксимоваП. Е.
Russian Federation

Bld. 7, 5 Lenin Boulevard, Simferopol 295051

295051 Симферополь, бульвар Ленина, 5, стр. 7

https://orcid.org/0000-0003-2684-3834LazarevA. E.ЛазаревА. Э.
Russian Federation

Bld. 7, 5 Lenin Boulevard, Simferopol 295051

295051 Симферополь, бульвар Ленина, 5, стр. 7

https://orcid.org/0000-0001-6239-885XBalakchinaA. I. БалакчинаА. И.
Russian Federation

Bld. 7, 5 Lenin Boulevard, Simferopol 295051

295051 Симферополь, бульвар Ленина, 5, стр. 7

https://orcid.org/0000-0002-3578-5130GolovkinI. O. ГоловкинИ. О.
Russian Federation

Bld. 7, 5 Lenin Boulevard, Simferopol 295051

295051 Симферополь, бульвар Ленина, 5, стр. 7

S.I. Georgievsky Medical Academy, V.I. Vernadsky Crimean Federal UniversityМедицинская академия им. С.И. Георгиевского ФГАОУ ВО «Крымский федеральный университет им. В.И. Вернадского»151220231048202305202314122023Copyright ©; 2023, Zyablitskaya E.Y., Kubyshkin A.V., Sorokina L.E., Serebryakova A.V., Aliev K.A., Maksimova P.E., Lazarev A.E., Balakchina A.I., Golovkin I.O.Copyright ©; 2023, Зяблицкая Е.Ю., Кубышкин А.В., Сорокина Л.Е., Серебрякова А.В., Алиев К.А., Максимова П.Е., Лазарев А.Э., Балакчина А.И., Головкин И.О.2023Zyablitskaya E.Y., Kubyshkin A.V., Sorokina L.E., Serebryakova A.V., Aliev K.A., Maksimova P.E., Lazarev A.E., Balakchina A.I., Golovkin I.O.Зяблицкая Е.Ю., Кубышкин А.В., Сорокина Л.Е., Серебрякова А.В., Алиев К.А., Максимова П.Е., Лазарев А.Э., Балакчина А.И., Головкин И.О.https://creativecommons.org/licenses/by/4.0https://umo.abvpress.ru/jour/article/view/604

The dynamic relationships between tumor cells and their microenvironment are of crucial importance in the development and progression of the malignant process. Given the multifunctional potential of heterogeneous populations surrounding a tumor, targeting components of the microenvironment has long been regarded as a promising strategy in modern anticancer therapy. This review discusses the role of the components of the cellular microenvironment in carcinogenesis, analyzes in detail the main ways and mechanisms of action on the main cell populations, which are of the greatest interest in the context of the development of innovative anticancer therapy.

Динамические взаимоотношения между опухолевыми клетками и их микроокружением имеют решающее значение в развитии и прогрессировании злокачественного процесса. С учетом мультифункционального потенциала гетерогенных популяций, окружающих опухоль, нацеливание на компоненты микроокружения уже давно рассматривается как перспективная стратегия в современной терапии новообразований. В настоящем  обзоре проанализированы роль компонентов клеточного микроокружения в канцерогенезе, а также пути и механизмы воздействия на основные популяции клеток, представляющие наибольший интерес в контексте разработки новых подходов к лечению злокачественных опухолей.

tumor microenvironmentmalignant neoplasmsanticancer therapyмикроокружение опухолизлокачественные новообразованияпротивоопухолевая терапияThe study was financially supported by the Ministry of Education and Science of the Russia (State Assignment No. FZEG-2023-0009 “Study of the heterogeneity of the tumor microenvironment as a factor in its aggressiveness and resistance to therapy”). The figures were prepared using adapted materials (BioRender.com license at https://www.biorender.com/).Работа выполнена при финансовой поддержке Минобрнауки России (государственное задание № FZEG-2023-0009 «Изучение гетерогенности микроокружения опухоли как фактора ее агрессивности и резистентности к терапии»). Рисунки были подготовлены с использованием адаптированных материалов BioRender.com (https://www.biorender.com/).Koontongkaew S. The tumor microenvironment contribution to development, growth, invasion and metastasis of head and neck squamous cell carcinomas. J Cancer 2013;4(1):66–83. 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