Advances in Molecular OncologyAdvances in Molecular OncologyУспехи молекулярной онкологии2313-805X2413-3787Publishing House ABV Press64510.17650/2313-805X-2024-11-1-8-21REVIEWОБЗОРНАЯ СТАТЬЯThe role of ABC-transporters in homeostasis, cancer pathogenesis and therapyРоль ABC-транспортеров в поддержании гомеостаза, патогенезе и терапии онкологических заболеванийhttps://orcid.org/0000-0003-2415-1084BoichukS. V.БойчукС. В.
Russian Federation

Sergey Vasilyevich Boychuk

49 Butlerova St., Kazan 420012; 18 Kremlevskaya St., Kazan 420008; Bld. 1, 2/1 Barricadnaya St., Moscow 125993

Сергей Васильевич Бойчук

420012 Казань, ул. Бутлерова, 49; 420008 Казань, ул. Кремлевская, 18; 125993 Москва, ул. Баррикадная, 2/1, стр. 1

boichuksergei@mail.ruhttps://orcid.org/0009-0003-4348-9141IvoilovaT. V.ИвойловаТ. В.
Russian Federation

49 Butlerova St., Kazan 420012

420012 Казань, ул. Бутлерова, 49

Kazan State Medical University, Ministry of Health of RussiaФГБОУ ВО «Казанский государственный медицинский университет» Минздрава РоссииResearch Laboratory “Biomarker”, Institute of Fundamental Medicine and Biology of the Kazan Federal UniversityНаучно-исследовательская лаборатория «Биомаркер», Институт фундаментальной медицины и биологии ФГАОУ ВО «Казанский (Приволжский) федеральный университет»Russian Medical Academy of Continuing Professional EducationФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования»150120241118210504202405042024Copyright ©; 2024, Boichuk S.V., Ivoilova T.V.Copyright ©; 2024, Бойчук С.В., Ивойлова Т.В.2024Boichuk S.V., Ivoilova T.V.Бойчук С.В., Ивойлова Т.В.https://creativecommons.org/licenses/by/4.0https://umo.abvpress.ru/jour/article/view/645

ABC transporters (ATP Binding Cassette (ABC) transporters) are proteins, which play a dual role in the substances transport across the membrane. On the one hand, they transport nutrients and other molecules inside the cell to supply the necessary nutrients, on the other hand, these proteins excrete some endogenous and exogenous substrates from the cell to maintain their homeostasis in the body and prevent from effects of aggressive environment. ABC transporters play a role in the pathogenesis of various metabolic disorders. In addition, a large amount of evidence has been accumulated about the participation of these proteins in oncogenesis because of their involvement into initiation, progression, invasion and metastasis of tumors, as well as development of multidrug resistance phenotype. Currently, these proteins are attractive therapeutic targets, influence on which can significantly increase the effectiveness of anticancer therapy and improve the prognosis of patients with oncological diseases, including recurrent, metastatic and inoperable forms.

The review provides information on drugs that affect the functional activity of ABC transporters and the mechanisms of their action, and also presents the results of clinical trials of these inhibitors.

ABC-транспортеры (ATP binding cassette (ABC) transporters), АТФ-зависимые транспортеры – белки, играющие двоякую роль в переносе веществ через мембрану. С одной стороны, они транспортируют питательные вещества и другие молекулы внутрь клетки, поставляя необходимые нутриенты, с другой, экскретируют некоторые эндогенные и экзогенные субстраты из клетки, поддерживая их гомеостаз в организме и предотвращая агрессивные воздействия внешней среды. ABC-транспортеры, исходя из своих функций, играют большую роль в патогенезе различных метаболических нарушений. Кроме того, накоплено много данных об участии этих белков в онкогенезе за счет их вклада в инициацию, прогрессию, инвазию и метастазирование опухолей, а также в развитие фенотипа множественной лекарственной устойчивости. В настоящее время данные белки являются привлекательными терапевтическими мишенями, воздействие на которые способно существенным образом повысить эффективность противоопухолевой терапии и улучшить прогноз пациентов с онкологическими заболеваниями, в том числе рецидивирующих, метастатических и неоперабельных форм. В обзоре представлена информация о лекарственных препаратах как являющихся субстратами для ABC-транспортеров, так и оказывающих влияние на их функциональную активность, а также результаты клинических испытаний по изучению эффективности использования этих ингибиторов в практической онкологии.

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