Advances in Molecular OncologyAdvances in Molecular OncologyУспехи молекулярной онкологии2313-805X2413-3787Publishing House ABV Press67410.17650/2313-805X-2024-11-2-29-39REVIEW ARTICLESОБЗОРНЫЕ СТАТЬИThe most common forms of cancer and oncogenic papillomavirusesНаиболее распространенные формы рака и онкогенные папилломавирусыhttps://orcid.org/0000-0002-6817-2103VolgarevaG. M.ВолгареваГ. М.
Russian Federation

Galina Mikhailovna Volgareva

115522; 24 Kashirskoe Shosse; Moscow

Галина Михайловна Волгарева

115522; Каширское шоссе, 24; Москва

galina.volgareva@ronc.ruN.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России1505202411229392806202428062024Copyright ©; 2024, Volgareva G.M.Copyright ©; 2024, Волгарева Г.М.2024Volgareva G.M.Волгарева Г.М.https://creativecommons.org/licenses/by/4.0https://umo.abvpress.ru/jour/article/view/674

   Breast, prostate, lung as well as colorectal carcinomas belong to leading positions in the world cancer incidence and mortality rankings. They make up about 40 % of newly diagnosed cancers. Connection of these cancers with oncogenic human papilloma viruses (HPVs) is being examined intensively, however it remains subject for discussion. Basing on case-control meta-analyses data were examined on oncogenic HPV detection in clinical samples of breast, prostate, lung and colorectal carcinomas. Findings on HPV genome activities were summarized. The results available prove to oncogenic HPVs as risk factors of the four enumerated above carcinomas.

   В мировых рейтингах онкологической заболеваемости и смертности карциномам молочной и предстательной желез, легкого, а также толстой и прямой кишок принадлежат лидирующие позиции. Они составляют около 40 % вновь выявляемых случаев рака. Связь этих карцином с онкогенными вирусами папилломы человека (ВПЧ) активно изучается, но остается предметом дискуссий. На материалах метаанализов, выполненных по схеме «случай–контроль», проанализированы результаты детекции онкогенных ВПЧ в клинических образцах рака молочной и предстательной желез, легкого, толстой и прямой кишок; суммированы данные, полученные при попытках проверки активности геномов папилломавирусов в ВПЧ-положительных опухолях. Имеющиеся результаты подтверждают, что онкогенные ВПЧ являются факторами риска четырех перечисленных форм рака.

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