Advances in Molecular OncologyAdvances in Molecular OncologyУспехи молекулярной онкологии2313-805X2413-3787Publishing House ABV Press7010.17650/2313-805X-2016-3-3-56-66REVIEW ARTICLESОБЗОРНЫЕ СТАТЬИMorphological classification of digestive neuroendocrine neoplasms: the current concepts and controversiesМорфологическая классификация нэйроэндокринных новообразований пищеварительной системы: современное состояние проблемы и нерешенные вопросыDelektorskayaV. V.ДелекторскаяВ. В.
Russian Federation
delektorskaya@yandex.ruN. N. Blokhin Russian Cancer Reseach Center, Ministry of Health of RussiaФГБУ «Российский онкологический научный центр им. Н. Н. Блохина» Минздрава России24 Kashirskoe Shosse, Moscow, 115478, RussiaРоссия, 115478, Москва, Каширское шоссе, 24150920163356663009201630092016Copyright ©; 2016, Delektorskaya V.V.Copyright ©; 2016, Делекторская В.В.2016Delektorskaya V.V.Делекторская В.В.https://creativecommons.org/licenses/by/4.0https://umo.abvpress.ru/jour/article/view/70

Neuroendocrine tumors comprise the heterogeneous group of malignant epithelial neoplasms, the diagnosis of which is based on their histopathologic features and immunohistochemical profile. For neuroendocrine tumors of the digestive system in the World Health Organization (2010) classification were introduced main categories, the nomenclature, criterions for grading and staging. However, accumulating evidence demonstrates actual controversies in the histopathology of neuroendocrine neoplasms and unreserved problems in their classification. In this review we focus on some of the common features of neuroendocrine neoplasms, their classification, and differences in pathology, biology of the main categories, and the most important immunohistochemical markers.

Нейроэндокринные опухоли образуют разнородную группу злокачественных эпителиальных новообразований, диагностика которых основывается на особенностях гистологической структуры и иммуногистохимического профиля. В классификации Всемирной организации здравоохранения (2010) для нейроэндокринных новообразований пищеварительной системы были определены основные категории, номенклатура, критерии градации и стадирования. При этом накопленные данные демонстрируют ряд важных патоморфологических противоречий в подходе к классификации. В данном обзоре мы остановимся на некоторых общих особенностях нейроэндокринных новообразований, их классификации, морфологических и биологических различиях основных категорий, наиболее важных иммуногистохимических маркерах.

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