Advances in Molecular OncologyAdvances in Molecular OncologyУспехи молекулярной онкологии2313-805X2413-3787Publishing House ABV Press70710.17650/2313-805X-2024-11-3-41-55REVIEW ARTICLESОБЗОРНЫЕ СТАТЬИTwo-faced Janus: on the 150th anniversary of the discovery of DDTДвуликий Янус: к 150-летию открытия ДДТMorozovaO. V.МорозоваО. В.
Russian Federation

24 Kashirskoe Shosse, Moscow 115522

115522 Москва, Каширское шоссе, 24

https://orcid.org/0000-0002-0963-3432BukinaA. Yu.БукинаА. Ю.
Russian Federation

24 Kashirskoe Shosse, Moscow 115522

78 Vernadskogo Prospekt, Moscow 119454

115522 Москва, Каширское шоссе, 24

119454 Москва, пр-кт Вернадского, 78

https://orcid.org/0000-0002-7301-605XPopovaV. G.ПоповаВ. Г.
Russian Federation

24 Kashirskoe Shosse, Moscow 115522

115522 Москва, Каширское шоссе, 24

https://orcid.org/0000-0001-5545-1157KhairievaG. I.ХайриеваГ. И.
Russian Federation

Bld. 2, 8 Trubetskaya St., Moscow 119991

119991 Москва, ул. Трубецкая, 8, стр. 2

https://orcid.org/0000-0003-3940-0661SagitovaG. R.СагитоваГ. Р.
Russian Federation

Bld. 2, 8 Trubetskaya St., Moscow 119991

119991 Москва, ул. Трубецкая, 8, стр. 2

https://orcid.org/0000-0002-3167-7204BelitskyG. A.БелицкийГ. А.
Russian Federation

24 Kashirskoe Shosse, Moscow 115522

115522 Москва, Каширское шоссе, 24

https://orcid.org/0000-0002-9710-8178YakubovskayaM. G.ЯкубовскаяМ. Г.
Russian Federation

24 Kashirskoe Shosse, Moscow 115522

115522 Москва, Каширское шоссе, 24

https://orcid.org/0000-0002-8599-6833KirsanovK. I.КирсановК. И.
Russian Federation

24 Kashirskoe Shosse, Moscow 115522

6 Miklukho-Maklaya St., Moscow 117198

115522 Москва, Каширское шоссе, 24

117198 Москва, ул. Миклухо-Маклая, 6

https://orcid.org/0000-0003-0896-2952MaksimovaV. P.МаксимоваВ. П.
Russian Federation

Varvara Pavlovna Maksimovaм

24 Kashirskoe Shosse, Moscow 115522

Варвара Павловна Максимова

115522 Москва, Каширское шоссе, 24

lavarvar@gmail.comN.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава РоссииMIREA – Russian Technological UniversityФГБУ ВО «МИРЭА – Российский технологический университет»Sechenov University, Ministry of Health of RussiaФГАОУ ВО Первый Московский государственный медицинский университет им. И.М. Сеченова Минздрава России (Сеченовский Университет)Peoples’ Friendship University of RussiaФГАОУ ВО «Российский университет дружбы народов»1509202411341551010202410102024Copyright ©; 2024, Morozova O.V., Bukina A.Y., Popova V.G., Khairieva G.I., Sagitova G.R., Belitsky G.A., Yakubovskaya M.G., Kirsanov K.I., Maksimova V.P.Copyright ©; 2024, Морозова О.В., Букина А.Ю., Попова В.Г., Хайриева Г.И., Сагитова Г.Р., Белицкий Г.А., Якубовская М.Г., Кирсанов К.И., Максимова В.П.2024Morozova O.V., Bukina A.Y., Popova V.G., Khairieva G.I., Sagitova G.R., Belitsky G.A., Yakubovskaya M.G., Kirsanov K.I., Maksimova V.P.Морозова О.В., Букина А.Ю., Попова В.Г., Хайриева Г.И., Сагитова Г.Р., Белицкий Г.А., Якубовская М.Г., Кирсанов К.И., Максимова В.П.https://creativecommons.org/licenses/by/4.0https://umo.abvpress.ru/jour/article/view/707

One of the factors associated with increased morbidity of malignant neoplasms is environmental pollution with cancerogenic compounds including pesticides. Until recently, stable organic pollutant insecticide dichlorodiphenyltrichloroethane (DDT) was the single tool for fighting malaria carriers. Despite vast evidence of its negative effect on human health, DDT is still used in some countries.Aim. To perform a comprehensive analysis of the dynamics of DDT pesticide use and the consequences of its use on the global healthcare as well as to investigate the mechanism of its action on the human body including the endocrine system and cancerogenic effects.The review was composed using the PubMed (2853 publications), Elsevier (3139 publications), eLibrary (784 publications) biomedical literature databases. Full-text articles were retrieved through PubMed Central (PMC), Science Direct, Research Gate, CyberLeninka electronic resources.

Одним из факторов, ассоциированных с ростом заболеваемости злокачественными новообразованиями, является загрязнение окружающей среды канцерогенными соединениями, в том числе пестицидами. Стойкий органический загрязнитель инсектицид дихлордифенилтрихлорэтан (ДДТ) до недавнего времени был безальтернативным средством для борьбы с переносчиками малярии. Несмотря на многочисленные доказательства негативного действия на здоровье человека, ДДТ и в настоящее время используется в некоторых странах.Цель обзора – всесторонний анализ динамики применения пестицида ДДТ и влияния последствий его использования на сферу глобального здравоохранения, а также исследование механизмов его действия на организм человека, включая влияние на эндокринную систему и канцерогенные эффекты.При подготовке обзора использованы базы биомедицинской литературы PubMed (2853 публикации), Elsivier (3139 публикаций), eLibrary (784 публикации), а для получения полнотекстовых документов – электронные ресурсы PubMed Central (PMC), Science Direct, Research Gate, КиберЛенинка.

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