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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Advances in Molecular Oncology</journal-id><journal-title-group><journal-title xml:lang="en">Advances in Molecular Oncology</journal-title><trans-title-group xml:lang="ru"><trans-title>Успехи молекулярной онкологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2313-805X</issn><issn publication-format="electronic">2413-3787</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">8</article-id><article-id pub-id-type="doi">10.17650/2313-805X.2015.2.1.082-089</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>RESEARCH ARTICLES</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ЭКСПЕРИМЕНТАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Biochemical criteria of toxicity of therapy with high doses of methotrexate in children with osteosarcoma</article-title><trans-title-group xml:lang="ru"><trans-title>Биохимические критерии токсичности терапии высокими дозами метотрексата у детей с остеосаркомой</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Strizhevskaya</surname><given-names>A. M.</given-names></name><name xml:lang="ru"><surname>Стрижевская</surname><given-names>Александра Михайловна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Centralized Clinical and Laboratory Department, Research Institute of Clinical Oncology, 23 Kashirskoye Highway, Moscow, 115478, Russia</p></bio><bio xml:lang="ru"><p>Централизованный клинико-лабораторный отдел, Россия, 115478, Москва, Каширское шоссе, 23</p></bio><email>Strizhevsky@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Golovnya</surname><given-names>E. G.</given-names></name><name xml:lang="ru"><surname>Головня</surname><given-names>Е. Г.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Centralized Clinical and Laboratory Department, Research Institute of Clinical Oncology, 23 Kashirskoye Highway, Moscow, 115478, Russia</p></bio><bio xml:lang="ru"><p>Централизованный клинико-лабораторный отдел, Россия, 115478, Москва, Каширское шоссе, 23</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Dzampaev</surname><given-names>A. Z.</given-names></name><name xml:lang="ru"><surname>Дзампаев</surname><given-names>А. З.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Department of Musculoskeletal System, Research Institute of Children Hematology and Oncology, 23 Kashirskoye Highway, Moscow, 115478, Russia</p></bio><bio xml:lang="ru"><p>отделение опорно-двигательного аппарата, Россия, 115478, Москва, Каширское шоссе, 23</p></bio><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Baykova</surname><given-names>V. N.</given-names></name><name xml:lang="ru"><surname>Байкова</surname><given-names>В. Н.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Centralized Clinical and Laboratory Department, Research Institute of Clinical Oncology, 23 Kashirskoye Highway, Moscow, 115478, Russia</p></bio><bio xml:lang="ru"><p>Централизованный клинико-лабораторный отдел, Россия, 115478, Москва, Каширское шоссе, 23</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">N.N. Blokhin Russian Cancer Research Center</institution></aff><aff><institution xml:lang="ru">НИИ клинической онкологии ФГБНУ «РОНЦ им. Н.Н. Блохина»</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">N.N. Blokhin Russian Cancer Research Center</institution></aff><aff><institution xml:lang="ru">НИИ детской онкологии и гематологии ФГБНУ «РОНЦ им. Н.Н. Блохина»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2015-01-15" publication-format="electronic"><day>15</day><month>01</month><year>2015</year></pub-date><volume>2</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>082</fpage><lpage>089</lpage><history><date date-type="received" iso-8601-date="2015-06-02"><day>02</day><month>06</month><year>2015</year></date><date date-type="accepted" iso-8601-date="2015-06-02"><day>02</day><month>06</month><year>2015</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2015, Strizhevskaya A.M., Golovnya E.G., Dzampaev A.Z., Baykova V.N.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2015, Стрижевская А.М., Головня Е.Г., Дзампаев А.З., Байкова В.Н.</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="en">Strizhevskaya A.M., Golovnya E.G., Dzampaev A.Z., Baykova V.N.</copyright-holder><copyright-holder xml:lang="ru">Стрижевская А.М., Головня Е.Г., Дзампаев А.З., Байкова В.Н.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://umo.abvpress.ru/jour/article/view/8">https://umo.abvpress.ru/jour/article/view/8</self-uri><abstract xml:lang="en"><p/></abstract><trans-abstract xml:lang="ru"><p/></trans-abstract><kwd-group xml:lang="en"><kwd>children</kwd><kwd>high-dose methotrexate</kwd><kwd>cancer</kwd><kwd>therapeutic drug monitoring</kwd><kwd>toxicokinetics</kwd><kwd>toxicity</kwd><kwd>homocysteine</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>дети</kwd><kwd>высокие дозы метотрексата</kwd><kwd>остеосаркомы</kwd><kwd>терапевтический лекарственный мониторинг</kwd><kwd>токсикокинетика</kwd><kwd>фармакокинетика</kwd><kwd>гомоцистеин</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. 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