Advances in Molecular OncologyAdvances in Molecular OncologyУспехи молекулярной онкологии2313-805X2413-3787Publishing House ABV Press81410.17650/2313-805X-2025-12-3-36-45REVIEW ARTICLESОБЗОРНЫЕ СТАТЬИIn vitro models of soft tissue sarcomas: basic and clinical aspectsМодели сарком мягких тканей in vitro: фундаментальные и клинические аспектыhttps://orcid.org/0000-0003-2179-5685BokovaU. A.БоковаУ. А.
Russian Federation

Ustinya Anatolyevna Bokova

5 Kooperativny Line, Tomsk 634009, Russia

Устинья Анатольевна Бокова 

Россия, 634009 Томск, пер. Кооперативный, 5

pushkay@yandex.ruhttps://orcid.org/0000-0002-5040-931XTretyakovaM. S.ТретьяковаМ. С.
Russian Federation

5 Kooperativny Line, Tomsk 634009, Russia

Россия, 634009 Томск, пер. Кооперативный, 5

https://orcid.org/0009-0003-4139-2338KozlovaP. K.КозловаП. К.
Russian Federation

5 Kooperativny Line, Tomsk 634009, Russia

Россия, 634009 Томск, пер. Кооперативный, 5

https://orcid.org/0000-0002-2633-9884KorobeynikovaA. A.КоробейниковаА. А.
Russian Federation

5 Kooperativny Line, Tomsk 634009, Russia

Россия, 634009 Томск, пер. Кооперативный, 5

https://orcid.org/0000-0003-4630-4934MenyailoM. E.МеняйлоМ. Е.
Russian Federation

5 Kooperativny Line, Tomsk 634009, Russia

Россия, 634009 Томск, пер. Кооперативный, 5

https://orcid.org/0000-0002-7283-0092GerashchenkoT. S.ГеращенкоТ. С.
Russian Federation

5 Kooperativny Line, Tomsk 634009, Russia

Россия, 634009 Томск, пер. Кооперативный, 5

https://orcid.org/0000-0003-2923-9755DenisovE. V.ДенисовЕ. В.
Russian Federation

5 Kooperativny Line, Tomsk 634009, Russia

Россия, 634009 Томск, пер. Кооперативный, 5

Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of SciencesНаучно-исследовательский институт онкологии ФГБНУ «Томский национальный исследовательский медицинский центр Российской академии наук»0610202512336450510202505102025Copyright ©; 2025, Bokova U.A., Tretyakova M.S., Kozlova P.K., Korobeynikova A.A., Menyailo M.E., Gerashchenko T.S., Denisov E.V.Copyright ©; 2025, Бокова У.А., Третьякова М.С., Козлова П.К., Коробейникова А.А., Меняйло М.Е., Геращенко Т.С., Денисов Е.В.2025Bokova U.A., Tretyakova M.S., Kozlova P.K., Korobeynikova A.A., Menyailo M.E., Gerashchenko T.S., Denisov E.V.Бокова У.А., Третьякова М.С., Козлова П.К., Коробейникова А.А., Меняйло М.Е., Геращенко Т.С., Денисов Е.В.https://creativecommons.org/licenses/by/4.0https://umo.abvpress.ru/jour/article/view/814

Diagnosis and selection of effective therapy of soft tissue sarcomas (STS) are complicated by low incidence and significant histological variability of these tumors. Development of molecular and genetic testing methods is aimed at improving differential diagnosis of different types of STS and identification of genetic abnormalities which can potentially serve as targets for therapy. Development of effective treatment methods requires adequate preclinical models capable of recreating biological features of the tumors. The article presents molecular and genetic testing methods for STS diagnosis and therapy, advances in in vitro STS models, problems with their use in preclinical studies, as well as possibilities of using primary cell cultures for personalized treatment.

Диагностика и подбор эффективной терапии сарком мягких тканей (СМТ) затруднены в связи с низкой распространенностью и значительной гистологической вариабельностью данных опухолей. Развитие молекулярно-генетических методов тестирования направлено на улучшение дифференциальной диагностики различных типов СМТ и поиск генетических нарушений, которые могут являться потенциальными мишенями для терапии. Разработка эффективных методов лечения требует адекватных доклинических моделей, способных воспроизводить биологические особенности опухолей. В статье представлены молекулярно-генетические методы тестирования для диагностики и терапии СМТ, достижения в получении моделей in vitro СМТ, проблемы их использования в доклинических исследованиях, а также перспективы использования первичных клеточных линий для персонализированного лечения.

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