Advances in Molecular OncologyAdvances in Molecular OncologyУспехи молекулярной онкологии2313-805X2413-3787Publishing House ABV Press84510.17650/2313-805X-2026-13-2-19-25REVIEW ARTICLESОБЗОРНЫЕ СТАТЬИReview ArticleLaminins: role in invasion, metastasis, and prognosis of malignant neoplasms of various localizationsЛаминины: роль в инвазии, метастазировании и прогнозе злокачественных новообразований разной локализацииhttps://orcid.org/0000-0001-9429-9813ZavyalovaM. V.ЗавьяловаМ. В.
Russian Federation

Cancer Research Institute

Научно-исследовательский институт онкологии

pismenniy.dmitry@yandex.ruhttps://orcid.org/0000-0002-9443-7224KuznetsovG. A.КузнецовГ. А.
Russian Federation
pismenniy.dmitry@yandex.ruhttps://orcid.org/0009-0009-0266-6707ZavyalovA. V.ЗавьяловА. В.
Russian Federation
pismenniy.dmitry@yandex.ruhttps://orcid.org/0000-0001-8973-8439PismenniyDmitry S.ПисьменныйДмитрий Сергеевич
Russian Federation

Cancer Research Institute

Научно-исследовательский институт онкологии

pismenniy.dmitry@yandex.ruhttps://orcid.org/0000-0002-5510-1808PankovaO. V.ПанковаО. В.
Russian Federation

Cancer Research Institute

Научно-исследовательский институт онкологии

pismenniy.dmitry@yandex.ruhttps://orcid.org/0009-0001-9740-7776PopovaV. E.ПоповаВ. Е.
Russian Federation
pismenniy.dmitry@yandex.ruhttps://orcid.org/0000-0002-7633-9620PerelmuterV. M.ПерельмутерВ. М.
Russian Federation

Cancer Research Institute

Научно-исследовательский институт онкологии ФГБНУ

pismenniy.dmitry@yandex.ruTomsk National Research Medical Center of the Russian Academy of SciencesФГБНУ «Томский национальный исследовательский медицинский центр Российской академии наук»Siberian State Medical University, Ministry of Health of the RussiaСибирский государственный медицинский университет19062026132192529122025Copyright ©; 2026, ABV-PressCopyright ©; 2026, АБВ-пресс2026ABV-PressАБВ-прессhttps://creativecommons.org/licenses/by/4.0/https://umo.abvpress.ru/jour/article/view/845

Laminins are a family of high-molecular-weight heterotrimeric glycoproteins of the extracellular matrix that play a key structural role in basement membranes. Although mutations in intracellular proteins remain the primary drivers of carcinogenesis, the role of changes in the expression and spatial distribution of laminins in the development of malignant neoplasms is gaining increasing importance. Primary focus is given to the patterns of laminin alterations in carcinomas of various localizations, as well as their role in the acquisition of invasive and metastatic potential by tumor cells. Furthermore, the prognostic significance of different laminin isoforms is discussed.

Ламинины представляют собой семейство высокомолекулярных гетеротримерных гликопротеинов внеклеточного матрикса, выполняющих ключевую структурную роль в базальных мембранах. Несмотря на то что мутации генов остаются ключевыми драйверами канцерогенеза, роль изменений экспрессии и пространственного распределения ламининов в развитии злокачественных новообразований приобретает все большее значение. В статье основное внимание уделяется паттернам изменений ламининов при карциномах различной локализации, а также их роли в приобретении опухолевыми клетками инвазивного и метастатического потенциалов. Кроме того, рассматривается прогностическое значение различных изоформ ламининов.

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