Email this article Mechanisms of carcinogenesis prevention by flavonoids
- Authors: Belitsky G.A.1, Kirsanov K.I.1, Lesovaya E.A.1, Yakubovskaya M.G.1
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Affiliations:
- Federal State Budgetary Institution “N. N. Blokhin Russiаn Cancer Research Center”, Russian Academy of Medical Sciences, Moscow
- Issue: Vol 1, No 1 (2014)
- Pages: 56-68
- Section: REVIEW ARTICLES
- Published: 02.06.2015
- URL: https://umo.abvpress.ru/jour/article/view/17
- DOI: https://doi.org/10.17650/2313-805X.2014.1.1.56-68
- ID: 17
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Abstract
The mechanisms of anticancerogenic effects of flavanoids and isocyanates from the plants widely consumed in the midland belt of Russia were reviewed. Data of studies both in vitro and in vivo were analyzed. Special attention was paid to inhibition of targets responsible for carcinogen metabolic activation, carcinogenesis promotion and tumor progression as well as neoangiogenesis. Besides that the antioxidant properties of flavonoids and their effects on cell cycle regulation, apoptosis initiation and cell mobility were considered.
About the authors
G. A. Belitsky
Federal State Budgetary Institution “N. N. Blokhin Russiаn Cancer Research Center”, Russian Academy of Medical Sciences, Moscow
Email: fake@neicon.ru
Russian Federation
K. I. Kirsanov
Federal State Budgetary Institution “N. N. Blokhin Russiаn Cancer Research Center”, Russian Academy of Medical Sciences, Moscow
Email: fake@neicon.ru
Russian Federation
E. A. Lesovaya
Federal State Budgetary Institution “N. N. Blokhin Russiаn Cancer Research Center”, Russian Academy of Medical Sciences, Moscow
Email: fake@neicon.ru
Russian Federation
M. G. Yakubovskaya
Federal State Budgetary Institution “N. N. Blokhin Russiаn Cancer Research Center”, Russian Academy of Medical Sciences, Moscow
Author for correspondence.
Email: mgyakubovskaya@mail.ru
Russian Federation
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