Prevalence of HPV/p16+ infection among oropharyngeal squamous cell carcinoma patients in a tertiary care centre in Southern India

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Abstract

Introduction. Oropharyngeal squamous cell carcinomas are often found to be associated with human papilloma virus (HPV) infection. The prevalence of HPV infection among oropharyngeal squamous cell carcinomas patients in India is comparatively lower to that of the same worldwide.

Aim. To find out the prevalence of HPV infection among oropharyngeal squamous cell carcinomas patients who presented in our hospital.

Settings and design. Retrospective cross-sectional study.

Materials and methods. Tissue block of 60 patients with biopsy-proven oropharyngeal squamous cell carcinomas were subjected to immunohistochemistry for evaluating p16 expression. The p16 expression pattern was correlated with the demographic details. Data was entered in Microsoft Excel and Statistical Analysis was done with the help of SPSS version 22 (IBM Corp. Released, 2013. IBM SPSS Statistics for Windows, Version 22.0. Armonk, NY: IBM Corp.).

Results. Prevalence of HPV infection in our study was found to be 11.7 %. 85.8 % of all p16-positive patients had moderate-well differentiated disease. 6 out of 7 p16-positive patients had higher T stage (T3–4). All the patients who were p16+ were found to have a higher Nodal stage (N2–3). 100 % of all p16+ patients were found to have stage IV disease.

Conclusion. Prevalence of HPV infection was found to be similar to that of previous studies conducted in India. These patients also presented with advanced nodal disease at presentation and thereby, an advanced overall stage.

About the authors

V. Jawahar

Department of Radiation Oncology, Kasturba Medical College Mangalore, Manipal Academy of Higher Education

Email: fake@neicon.ru
ORCID iD: 0009-0009-1948-810X

Manipal

India

S. Banerjee

Department of Radiation Oncology, Kasturba Medical College Mangalore, Manipal Academy of Higher Education

Email: fake@neicon.ru
ORCID iD: 0000-0003-4710-2701

Manipal

India

J. Kini

Department of Pathology, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal

Email: fake@neicon.ru
ORCID iD: 0000-0002-3351-9517

Manipal

India

S. Sreeram

Department of Pathology, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal

Email: fake@neicon.ru
ORCID iD: 0000-0003-4149-0766

Manipal

India

M. S. Athiyamaan

Department of Radiation Oncology, Kasturba Medical College Mangalore, Manipal Academy of Higher Education

Author for correspondence.
Email: drathiyamaan.ms@gmail.com
ORCID iD: 0000-0003-4691-9728

Manipal

India

J. Sunny

Department of Radiation Oncology, Kasturba Medical College Mangalore, Manipal Academy of Higher Education

Email: fake@neicon.ru
ORCID iD: 0000-0001-8332-9618

Manipal

India

A. Krishna

Department of Radiation Oncology, Kasturba Medical College Mangalore, Manipal Academy of Higher Education

Email: fake@neicon.ru
ORCID iD: 0000-0002-9318-7024

Manipal

India

C. Srinivas

Department of Radiation Oncology, Kasturba Medical College Mangalore, Manipal Academy of Higher Education

Email: fake@neicon.ru
ORCID iD: 0000-0003-0355-487X

Manipal

India

D. Lobo

Department of Radiation Oncology, Kasturba Medical College Mangalore, Manipal Academy of Higher Education

Email: fake@neicon.ru
ORCID iD: 0000-0002-9222-863X

Manipal

India

B. S. Mokkapatti

Department of Radiation Oncology, Kasturba Medical College Mangalore, Manipal Academy of Higher Education

Email: fake@neicon.ru
ORCID iD: 0000-0002-1635-0289

Manipal

India

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