The role of ABC-transporters in homeostasis, cancer pathogenesis and therapy

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Abstract

ABC transporters (ATP Binding Cassette (ABC) transporters) are proteins, which play a dual role in the substances transport across the membrane. On the one hand, they transport nutrients and other molecules inside the cell to supply the necessary nutrients, on the other hand, these proteins excrete some endogenous and exogenous substrates from the cell to maintain their homeostasis in the body and prevent from effects of aggressive environment. ABC transporters play a role in the pathogenesis of various metabolic disorders. In addition, a large amount of evidence has been accumulated about the participation of these proteins in oncogenesis because of their involvement into initiation, progression, invasion and metastasis of tumors, as well as development of multidrug resistance phenotype. Currently, these proteins are attractive therapeutic targets, influence on which can significantly increase the effectiveness of anticancer therapy and improve the prognosis of patients with oncological diseases, including recurrent, metastatic and inoperable forms.

The review provides information on drugs that affect the functional activity of ABC transporters and the mechanisms of their action, and also presents the results of clinical trials of these inhibitors.

About the authors

S. V. Boichuk

Kazan State Medical University, Ministry of Health of Russia; Research Laboratory “Biomarker”, Institute of Fundamental Medicine and Biology of the Kazan Federal University; Russian Medical Academy of Continuing Professional Education

Author for correspondence.
Email: boichuksergei@mail.ru
ORCID iD: 0000-0003-2415-1084

Sergey Vasilyevich Boychuk

49 Butlerova St., Kazan 420012; 18 Kremlevskaya St., Kazan 420008; Bld. 1, 2/1 Barricadnaya St., Moscow 125993

Russian Federation

T. V. Ivoilova

Kazan State Medical University, Ministry of Health of Russia

Email: fake@neicon.ru
ORCID iD: 0009-0003-4348-9141

49 Butlerova St., Kazan 420012

Russian Federation

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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 57560 от  08.04.2014.