Email this article The transforming growth factor beta-1 in the oncogenesis of human lung adenocarcinoma
- Authors: Shevchenko V.E.1, Bryukhovetskiy I.S.2,3, Nikiforova Z.N.1, Kovalev S.V.4, Kudryavtsev I.A.1, Arnotskaya N.E.1
-
Affiliations:
- Research Institute of Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia.
- Biomedicine School, Far Eastern Federal University
- National Scientific Center of Marine Biology, Far Eastern Brach, Russian Academy of Sciences.
- Department of Chemistry, M.V. Lomonosov Moscow State University.
- Issue: Vol 4, No 3 (2017)
- Pages: 67-74
- Section: RESEARCH ARTICLES
- Published: 16.10.2017
- URL: https://umo.abvpress.ru/jour/article/view/103
- DOI: https://doi.org/10.17650/2313-805X-2017-4-3-67-74
- ID: 103
Cite item
Full Text
Abstract
Background. The transforming growth factor beta 1 (TGF-β1) is one of the most important tissue factors secreted by the development of epithelial tumors. Increased expression of TGF-β1 in lung tumors promotes cancer cells survival enhancing their growth, migration, invasion, angiogenesis, immune system suppression.
Objective: to study molecular mechanisms of TGF-β1 action on A549 human lung adenocarcinoma cells by means of proteomic high-resolution mass spectrometry. Results. Intracellular signaling pathways responsible for the involvement of TGF-β1 in the oncogenesis of non-small cell lung cancer have been found, which include the differential expressed proteins of the families of cullin, ETS oncogenes, histone diacelases, cyclin-dependent kinases, and the signaling pathway phosphatidylinositol 3-kinase (PI3K).
Conclusions. Important patterns are determined that could be used for the development of new approaches for detection of lung cancer metastasis candidate markers and potential therapy targets of this decease.
About the authors
V. E. Shevchenko
Research Institute of Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia.
Author for correspondence.
Email: vshev2015@yandex.ru
24 Kashirskoe Shosse, Moscow 115478. Russian Federation
I. S. Bryukhovetskiy
Biomedicine School, Far Eastern Federal University; National Scientific Center of Marine Biology, Far Eastern Brach, Russian Academy of Sciences.
Email: fake@neicon.ru
17 Pal’chevskogo St., Vladivostok 690059. Russian Federation
Z. N. Nikiforova
Research Institute of Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia.
Email: fake@neicon.ru
24 Kashirskoe Shosse, Moscow 115478. Russian Federation
S. V. Kovalev
Department of Chemistry, M.V. Lomonosov Moscow State University.
Email: fake@neicon.ru
GSP-1, Build. 3, 1 Leninskie Gory, Moscow 119991 Russian Federation
I. A. Kudryavtsev
Research Institute of Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia.
Email: fake@neicon.ru
24 Kashirskoe Shosse, Moscow 115478. Russian Federation
N. E. Arnotskaya
Research Institute of Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia.
Email: fake@neicon.ru
24 Kashirskoe Shosse, Moscow 115478. Russian Federation
References
Supplementary files
