Email this article Exosomes and development of cancer cell resistance to metformin: pilot study
- Authors: Semina S.E.1, Rudenskaya E.A.1, Mittenberg A.G.2, Shabel’nikov S.V.2, Krasil’nikov M.A.1
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Affiliations:
- Research Institute of Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia.
- Institute of Cytology of the Russian Academy of Sciences.
- Issue: Vol 4, No 3 (2017)
- Pages: 92-98
- Section: RESEARCH ARTICLES
- Published: 16.10.2017
- URL: https://umo.abvpress.ru/jour/article/view/106
- DOI: https://doi.org/10.17650/2313-805X-2017-4-3-92-98
- ID: 106
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Abstract
Objective: to study the role of the intercellular interactions in the progression of the cancer cells resistance to metformin, a biguanide antidiabetic drug exhibited the marked anti-tumor activity.
Results. Earlier we have demonstrated the effect of horizontal transferring of hormonal resistance of breast cancer cells from cell to cell, and showed the key role of exosomes on the transferring of the resistance. Here we have shown the effect of the horizontal transferring of metformin resistance in breast cancer cells – similar to the progression of hormonal resistance. We found that horizontal transferring of the metformin resistance is mediated via exosomes secreted by the resistant cells. The proteome analysis of the exosomes revealed several proteins differentially expressed in the exosomes of metformin-resistant cells and associated with the regulation of cell response to apoptotic drugs.
Conclusions. Totally, the data presented demonstrate the new mechanism of the development of the cancer cell resistance based on the intercellular interactions, opening the new insights in the target therapy of breast cancer.
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About the authors
S. E. Semina
Research Institute of Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia.
Author for correspondence.
Email: s.e.semina@gmail.com
24 Kashirskoe Shosse, Moscow 115478. Russian Federation
E. A. Rudenskaya
Research Institute of Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia.
Email: fake@neicon.ru
24 Kashirskoe Shosse, Moscow 115478. Russian Federation
A. G. Mittenberg
Institute of Cytology of the Russian Academy of Sciences.
Email: fake@neicon.ru
4 Tikhoretskiy Prospekt, Saint Petersburg 194064. Russian Federation
S. V. Shabel’nikov
Institute of Cytology of the Russian Academy of Sciences.
Email: fake@neicon.ru
4 Tikhoretskiy Prospekt, Saint Petersburg 194064. Russian Federation
M. A. Krasil’nikov
Research Institute of Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia.
Email: fake@neicon.ru
24 Kashirskoe Shosse, Moscow 115478. Russian Federation
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