CYCLOPHILIN A: STRUCTURE AND FUNCTIONS
https://doi.org/10.17650/2313-805X-2017-4-4-17-23
Abstract
Cyclophilins belong to a large family of ancient conservative proteins with peptidyl-prolyl-cis-trans isomerase activity. The main member of this family – cyclophilin A – was discovered as an intracellular ligand for cyclosporine A. Further investigations revealed a wide range of functions of cyclophilin A. Cyclophilin A is involved in T-cell signaling, it takes part in folding, assembly and intracellular transport of proteins, as well as acts as an antioxidant. Different cell types secrete cyclophilin A under infection or oxidative stress. Cyclophilin A is one of the main factors involved in inflammation and pathogenesis of autoimmune, cardiovascular and other diseases. This protein is thought to take part in tumor progression. In this review we describe the structure of cyclophilin A and its main known functions in health and disease.
About the Authors
A. A. Kalinina
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
24 Kashirskoe Shosse, Moscow 115478
L. M. Khromykh
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
24 Kashirskoe Shosse, Moscow 115478
D. B. Kazansky
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
24 Kashirskoe Shosse, Moscow 115478
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Review
For citations:
Kalinina A.A., Khromykh L.M., Kazansky D.B. CYCLOPHILIN A: STRUCTURE AND FUNCTIONS. Advances in Molecular Oncology. 2017;4(4):17-23. (In Russ.) https://doi.org/10.17650/2313-805X-2017-4-4-17-23
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