Email this article Wnt-signaling pathway in pathogenesis of glioblastoma multiforme
- Authors: Vasilets Y.D.1, Arnotskaya N.E.1, Kudryavtsev I.A.1, Shevchenko V.E.1
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Affiliations:
- Research Institute of Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
- Issue: Vol 5, No 4 (2018)
- Pages: 94-103
- Section: REVIEW ARTICLES
- Published: 04.01.2019
- URL: https://umo.abvpress.ru/jour/article/view/178
- DOI: https://doi.org/10.17650/2313-805X-2018-5-4-94-103
- ID: 178
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Abstract
The Wnt-signaling pathway regulates various biological processes, such as embryonic development, self-renewal, proliferation, differentiation and migration of stem cells. The Wnt-signaling is involved in tumor progression by aberrant activation in stem-like cells, called cancer stem cells, in different kinds of tumor, including multiform glioblastoma. The Wnt-signaling promotes stemness, invasion, metastasis, therapeutic and immune resistance of cancer stem cells in multiform glioblastoma. To summarize, targeting the Wnt-signaling pathway as an oncogenic driver is the future hope for effective therapy of glioblastoma for which current standard therapy is not effective.
In this review, we focused on functions of the Wnt-signaling in cancer stem cells and involvement of the Wnt-signaling pathway in gliomagenesis.
About the authors
Yu. D. Vasilets
Research Institute of Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Email: fake@neicon.ru
ORCID iD: 0000-0002-6367-3785
24 Kashirskoe Shosse, Moscow 115478 Russian Federation
N. E. Arnotskaya
Research Institute of Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Email: fake@neicon.ru
ORCID iD: 0000-0002-0154-8604
24 Kashirskoe Shosse, Moscow 115478 Russian Federation
I. A. Kudryavtsev
Research Institute of Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Email: fake@neicon.ru
ORCID iD: 0000-0001-7588-1066
24 Kashirskoe Shosse, Moscow 115478 Russian Federation
V. E. Shevchenko
Research Institute of Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Author for correspondence.
Email: vshev2015@yandex.ru
ORCID iD: 0000-0002-0401-9900
24 Kashirskoe Shosse, Moscow 115478 Russian Federation
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