Протеомика в открытии маркеров рака предстательной железы
https://doi.org/10.17650/2313-805X.2015.2.2.17-28
Аннотация
Рак предстательной железы (РПЖ) занимает 2-е место в мире по распространенности среди злокачественных опухолей у мужчин. Протеомика представляет перспективный подход для открытия новых маркеров, которые могут улучшить эффективность лечения больных РПЖ. Для диагностики, прогноза и оценки эффективности терапии заболевания необходимы более специфичные и чувствительные маркеры, чем специфический антиген предстательной железы. Кроме того, протеомика может идентифицировать новые важные молекулярные мишени для терапии РПЖ. В настоящее время изучаются несколько возможных источников биомаркеров РПЖ, каждый из которых имеет свои достоинства и недостатки, включая ткань, мочу, сыворотку и плазму крови, секрет предстательной железы. Инновационные высокотехнологичные протеомные платформы сейчас идентифицируют и количественно определяют новые специфичные и чувствительные биомаркеры для обнаружения, стратификации и лечения РПЖ. Однако многие из них все еще далеки от использования в клинической практике.
В этом обзоре обсуждаются последние достижения в протеомных исследованиях РПЖ, уделяется особое внимание открытию биомаркеров и их применению в клинической практике для диагноcтики, прогноза течения заболевания и стратификации больных.
Ключевые слова
рак предстательной железы,
протеомика,
биомаркеры,
масс-спектрометрия,
опухолевая ткань,
жидкости организма
Об авторах
Валерий Евгеньевич Шевченко
НИИ канцерогенеза ФГБНУ «РОНЦ им. Н.Н. Блохина»
Россия
Россия, 115478, Москва, Каширское шоссе, 24
Россия
Россия, 115478, Москва, Каширское шоссе, 24
А. В. Оленич
Медицинский научный центр «МедБиоСпектр»
Россия
Россия, 115478, Москва, Каширское шоссе, 24, стр. 8
Россия
Россия, 115478, Москва, Каширское шоссе, 24, стр. 8
Н. Е. Арноцкий
НИИ канцерогенеза ФГБНУ «РОНЦ им. Н.Н. Блохина»
Россия
Россия, 115478, Москва, Каширское шоссе, 24
Россия
Россия, 115478, Москва, Каширское шоссе, 24
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Рецензия
Для цитирования:
Шевченко В.Е., Оленич А.В., Арноцкий Н.Е. Протеомика в открытии маркеров рака предстательной железы. Успехи молекулярной онкологии. 2015;2(2):17-28. https://doi.org/10.17650/2313-805X.2015.2.2.17-28
For citation:
Shevchenko V.E., Olenich A.V., Olenich N.E. The proteomics in prostate cancer biomarker discovery. Advances in Molecular Oncology. 2015;2(2):17-28. (In Russ.) https://doi.org/10.17650/2313-805X.2015.2.2.17-28
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