Email this article Effect of the exosome-mediated suppression of the estrogen signaling: the role in the progression of the hormonal resistance of breast cancer cells
- Authors: Sorokin D.V.1, Andreeva O.E.2, Mikhaevich E.I.2, Shchegolev Y.Y.2, Scherbakov A.M.2, Gudkova M.V.2, Krasil’nikov M.A.2
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Affiliations:
- НИИ канцерогенеза ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н. Н. Блохина» Минздрава России
- Research Institute of Carcinogenesis, N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
- Issue: Vol 7, No 3 (2020)
- Pages: 58-62
- Section: SHORT REPORT
- Published: 24.11.2020
- URL: https://umo.abvpress.ru/jour/article/view/291
- DOI: https://doi.org/10.17650/2313-805X-2020-7-3-58-62
- ID: 291
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Abstract
The most effective treatment of the hormone-dependent breast cancer is based on the antiestrogens SERM and aromatase inhibitor treatment, however its efficiency is limited by the acquired resistance to the drugs.
Previously we have revealed the effect of the transferring of the hormonal resistance from the resistant to the sensitive cells under in vitro cell co-cultivation, and demonstrated exosomes involvement in this process. Here we have shown that the exosomes of the resistant cells caused the marked inhibition of the estrogen signaling in the recipient cells, and identified microRNAs – ERα suppressors that overexpressed in the resistant exosomes.
Taken together, the results obtained demonstrate the important role of the estrogen signaling suppression in the exosome-induced transferring of the hormonal resistance, and revealed the involvement of the exosomal microRNA in the ERα down-regulation.
Keywords
About the authors
D. V. Sorokin
НИИ канцерогенеза ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н. Н. Блохина» Минздрава России
Author for correspondence.
Email: fake@neicon.ru
ORCID iD: 0000-0002-1264-7405
Россия, 115478 Москва, Каширское шоссе, 24, стр. 15 Russian Federation
O. E. Andreeva
Research Institute of Carcinogenesis, N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Email: fake@neicon.ru
ORCID iD: 0000-0002-6015-6619
Build. 15, 24 Kashirskoe Shosse, Moscow 115478, Russia Russian Federation
E. I. Mikhaevich
Research Institute of Carcinogenesis, N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Email: fake@neicon.ru
ORCID iD: 0000-0002-1299-9080
Build. 15, 24 Kashirskoe Shosse, Moscow 115478, Russia Russian Federation
Yu. Yu. Shchegolev
Research Institute of Carcinogenesis, N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Email: fake@neicon.ru
ORCID iD: 0000-0002-1490-6781
Build. 15, 24 Kashirskoe Shosse, Moscow 115478, Russia Russian Federation
A. M. Scherbakov
Research Institute of Carcinogenesis, N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Email: fake@neicon.ru
ORCID iD: 0000-0002-2974-9555
Build. 15, 24 Kashirskoe Shosse, Moscow 115478, Russia Russian Federation
M. V. Gudkova
Research Institute of Carcinogenesis, N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Email: fake@neicon.ru
ORCID iD: 0000-0003-2694-5232
Build. 15, 24 Kashirskoe Shosse, Moscow 115478, Russia Russian Federation
M. A. Krasil’nikov
Research Institute of Carcinogenesis, N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Email: krasilnikovm1@yandex.ru
ORCID iD: 0000-0002-5902-7633
Build. 15, 24 Kashirskoe Shosse, Moscow 115478, Russia Russian Federation
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