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Успехи молекулярной онкологии

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Экзосомы молока в качестве агентов доставки терапевтически значимых препаратов при онкологических заболеваниях

https://doi.org/10.17650/2313-805X-2022-9-2-23-31

Полный текст:

Аннотация

Экзосомы – это природные нановезикулы диаметром 40–100 нм, принимающие активное участие в переносе различных биологически активных веществ, а также в межклеточной коммуникации. Природное происхождение обусловливает биологическую совместимость экзосом с культурами клеток и делает их перспективными средствами доставки противоопухолевых препаратов. В настоящее время методы искусственного получения данных нановезикул не разработаны. Препараты экзосом, полученные из опухолевых клеток, непригодны для терапии. Молоко –биологическая жидкость, которая доступна в промышленных масштабах. Оно может быть универсальным источником экзосом, используемых в лечении онкологических заболеваний. Адресная доставка противоопухолевых препаратов при помощи экзосом молока позволяет снизить токсический эффект цитостатических средств, используемых в химиотерапии. В данном обзоре рассмотрены методы выделения экзосом из молока, их дополнительная очистка, анализ биологически значимых компонентов этих везикул – белков и нуклеиновых кислот, а также перспективы применения экзосом молока в терапии онкологических заболеваний.

Об авторах

С. Е. Седых
ФГБУН «Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук»; ФГБОУ ВО «Новосибирский национальный исследовательский государственный университет»
Россия

Сергей Евгеньевич Седых

630090 Новосибирск, проспект Академика Лаврентьева, 8;

630090 Новосибирск, ул. Пирогова, 2



А. М. Тимофеева
ФГБУН «Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук»
Россия

630090 Новосибирск, проспект Академика Лаврентьева, 8



А. Е. Кулешова
ФГБУН «Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук»
Россия

630090 Новосибирск, проспект Академика Лаврентьева, 8



Г. А. Невинский
ФГБУН «Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук»; ФГБОУ ВО «Новосибирский национальный исследовательский государственный университет»
Россия

630090 Новосибирск, проспект Академика Лаврентьева, 8;

630090 Новосибирск, ул. Пирогова, 2



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Рецензия

Для цитирования:


Седых С.Е., Тимофеева А.М., Кулешова А.Е., Невинский Г.А. Экзосомы молока в качестве агентов доставки терапевтически значимых препаратов при онкологических заболеваниях. Успехи молекулярной онкологии. 2022;9(2):23-31. https://doi.org/10.17650/2313-805X-2022-9-2-23-31

For citation:


Sedykh S.E., Timofeeva A.M., Kuleshova A.E., Nevinskiy G.A. Milk exosomes as delivery agents for therapy of cancer diseases. Advances in Molecular Oncology. 2022;9(2):23-31. (In Russ.) https://doi.org/10.17650/2313-805X-2022-9-2-23-31

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ISSN 2313-805X (Print)
ISSN 2413-3787 (Online)
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