Email this article Molecular determinants of transforming growth factor beta-1 action on human glioblastoma cells
- Authors: Shevchenko V.E.1,2, Kovalev S.V.3,4, Arnotskaya N.E.1,2, Nikiforova Z.N.1,2, Kudryavtsev I.A.1,2, Savchenko E.A.5,6, Bryukhovetskiy I.S.7,8,9,10
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Affiliations:
- Research Institute of Carcinogenesis, N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia
- 24 Kashirskoe Shosse, Moscow, 115478, Russia
- Department of Chemistry, M. V. Lomonosov Moscow State University
- GSP-1, Build. 3, 1 Leninskie Gory, Moscow, 119991, Russia
- Institute of Gene Biology, Russian Academy of Sciences
- 34/5 Vavilova St., Moscow, 119334, Russia
- Biomedicine School, Far Eastern Federal University
- 8 Sukhanova St., Vladivostok, 690091, Russia
- A. V. Zhirmunsky Institute of Sea Biology, Far Eastern Brach, Russian Academy of Sciences
- 17 Pal’chevskogo St., Vladivostok, 690059, Russia
- Issue: Vol 3, No 2 (2016)
- Pages: 50-59
- Section: RESEARCH ARTICLES
- Published: 07.06.2016
- URL: https://umo.abvpress.ru/jour/article/view/62
- DOI: https://doi.org/10.17650/2313-805X.2016.3.2.50-59
- ID: 62
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Abstract
Background. Increased expression of transforming growth factor beta-1 (TGF-β1) in malignant brain tumors promotes cancer cells survival enhancing their growth, migration, invasion, angiogenesis, immune system suppression.
Objective is to study molecular mechanisms of TGF-β1 action on U87 human glioblastoma cells by means of proteomic high-resolution massspectrometry.
Results. We have identified intracell signal pathways responsible for TGF-β1 involvement in malignant gliomas oncogenesis including differential expressed proteins of tight cell junctions, focal adhesion, histone deacetylases, heat shock, S100 family.
Conclusions. Important patterns are determined that could be used for the development of new approaches for detection of glioblastoma metastasis candidate markers and potential therapy targets of this decease.
About the authors
V. E. Shevchenko
Research Institute of Carcinogenesis, N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia; 24 Kashirskoe Shosse, Moscow, 115478, Russia
Author for correspondence.
Email: vshev2015@yandex.ru
Russian Federation
S. V. Kovalev
Department of Chemistry, M. V. Lomonosov Moscow State University; GSP-1, Build. 3, 1 Leninskie Gory, Moscow, 119991, RussiaRussian Federation
N. E. Arnotskaya
Research Institute of Carcinogenesis, N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia; 24 Kashirskoe Shosse, Moscow, 115478, RussiaRussian Federation
Z. N. Nikiforova
Research Institute of Carcinogenesis, N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia; 24 Kashirskoe Shosse, Moscow, 115478, RussiaRussian Federation
I. A. Kudryavtsev
Research Institute of Carcinogenesis, N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia; 24 Kashirskoe Shosse, Moscow, 115478, RussiaRussian Federation
E. A. Savchenko
Institute of Gene Biology, Russian Academy of Sciences; 34/5 Vavilova St., Moscow, 119334, RussiaRussian Federation
I. S. Bryukhovetskiy
Biomedicine School, Far Eastern Federal University; 8 Sukhanova St., Vladivostok, 690091, Russia;A. V. Zhirmunsky Institute of Sea Biology, Far Eastern Brach, Russian Academy of Sciences; 17 Pal’chevskogo St., Vladivostok, 690059, Russia
Russian Federation
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