Two-faced Janus: on the 150th anniversary of the discovery of DDT
O. V. Morozova, 
A. Yu. Bukina,
V. G. Popova,
G. I. Khairieva,
G. R. Sagitova,
G. A. Belitsky,
M. G. Yakubovskaya,
K. I. Kirsanov,
V. P. Maksimova
A. Yu. Bukina,
V. G. Popova,
G. I. Khairieva,
G. R. Sagitova,
G. A. Belitsky,
M. G. Yakubovskaya,
K. I. Kirsanov,
V. P. Maksimova https://doi.org/10.17650/2313-805X-2024-11-3-41-55
Abstract
One of the factors associated with increased morbidity of malignant neoplasms is environmental pollution with cancerogenic compounds including pesticides. Until recently, stable organic pollutant insecticide dichlorodiphenyltrichloroethane (DDT) was the single tool for fighting malaria carriers. Despite vast evidence of its negative effect on human health, DDT is still used in some countries.
Aim. To perform a comprehensive analysis of the dynamics of DDT pesticide use and the consequences of its use on the global healthcare as well as to investigate the mechanism of its action on the human body including the endocrine system and cancerogenic effects.
The review was composed using the PubMed (2853 publications), Elsevier (3139 publications), eLibrary (784 publications) biomedical literature databases. Full-text articles were retrieved through PubMed Central (PMC), Science Direct, Research Gate, CyberLeninka electronic resources.
About the Authors
O. V. Morozova
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
24 Kashirskoe Shosse, Moscow 115522
A. Yu. Bukina
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia; MIREA – Russian Technological University
Russian Federation
Russian Federation
24 Kashirskoe Shosse, Moscow 115522
78 Vernadskogo Prospekt, Moscow 119454
V. G. Popova
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
24 Kashirskoe Shosse, Moscow 115522
G. I. Khairieva
Sechenov University, Ministry of Health of Russia
Russian Federation
Russian Federation
Bld. 2, 8 Trubetskaya St., Moscow 119991
G. R. Sagitova
Sechenov University, Ministry of Health of Russia
Russian Federation
Russian Federation
Bld. 2, 8 Trubetskaya St., Moscow 119991
G. A. Belitsky
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
24 Kashirskoe Shosse, Moscow 115522
M. G. Yakubovskaya
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
24 Kashirskoe Shosse, Moscow 115522
K. I. Kirsanov
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia; Peoples’ Friendship University of Russia
Russian Federation
Russian Federation
24 Kashirskoe Shosse, Moscow 115522
6 Miklukho-Maklaya St., Moscow 117198
V. P. Maksimova
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Varvara Pavlovna Maksimovaм
24 Kashirskoe Shosse, Moscow 115522
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Morozova O.V., Bukina A.Yu., Popova V.G., Khairieva G.I., Sagitova G.R., Belitsky G.A., Yakubovskaya M.G., Kirsanov K.I., Maksimova V.P. Two-faced Janus: on the 150th anniversary of the discovery of DDT. Advances in Molecular Oncology. 2024;11(3):41-55. (In Russ.) https://doi.org/10.17650/2313-805X-2024-11-3-41-55
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