Роль нарушения цикла метионина в инициации и прогрессии злокачественных опухолей
https://doi.org/10.17650/2313-805X-2024-11-4-41-53
Аннотация
Метиониновый цикл отвечает за обмен веществ, связанных с метионином – одним из незаменимых аминокислотных компонентов белков. при нарушении регуляции этого процесса происходит накопление непротеиногенной аминокислоты гомоцистеина, что может негативно влиять на организм человека. Существует множество исследований, посвященных изучению воздействия данных нарушений на развитие болезней системы кровообращения, однако их роль в развитии злокачественных новообразований остается малоизученной. Цель обзора – проанализировать научные работы, в которых рассматривается влияние сбоя регуляции метионинового катаболизма на возникновение и прогрессирование опухолевого роста. Понимание метаболических изменений, связанных с канцерогенезом, имеет большое значение для разработки новых классов терапевтических препаратов, а также стратегий комбинированного противоопухолевого лечения, в том числе направленных на преодоление метаболических особенностей опухолевых клеток.
Об авторах
Т. Г. Рукша
ФГБОУ ВО «Красноярский государственный медицинский университет им. проф. В.Ф. Войно-Ясенецкого» Минздрава России
Россия
Россия
Татьяна Геннадьевна Рукша
660022 Красноярск, ул. Партизана Железняка, 1
М. Н. Курбат
УО «Гродненский государственный медицинский университет
Беларусь
Беларусь
230009 Гродно, ул. Горького, 80
Н. В. Палкина
ФГБОУ ВО «Красноярский государственный медицинский университет им. проф. В.Ф. Войно-Ясенецкого» Минздрава России
Россия
Россия
660022 Красноярск, ул. Партизана Железняка, 1
В. А. Куценко
ФГБОУ ВО «Красноярский государственный медицинский университет им. проф. В.Ф. Войно-Ясенецкого» Минздрава России
Россия
Россия
660022 Красноярск, ул. Партизана Железняка, 1
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Рецензия
Для цитирования:
Рукша Т.Г., Курбат М.Н., Палкина Н.В., Куценко В.А. Роль нарушения цикла метионина в инициации и прогрессии злокачественных опухолей. Успехи молекулярной онкологии. 2024;11(4):41-53. https://doi.org/10.17650/2313-805X-2024-11-4-41-53
For citation:
Ruksha T.G., Kurbat M.N., Palkina N.V., Kutsenko V.A. The role of methionine cycle disruption in the initiation and progression of malignant tumors. Advances in Molecular Oncology. 2024;11(4):41-53. (In Russ.) https://doi.org/10.17650/2313-805X-2024-11-4-41-53
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