Email this article Cancer as a result of genetic mosaicism
- Authors: Likhtensteyn A.V.1
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Affiliations:
- Research Institute of Carcinogenesis, N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia
- Issue: Vol 4, No 2 (2017)
- Pages: 26-35
- Section: REVIEW ARTICLES
- Published: 30.06.2017
- URL: https://umo.abvpress.ru/jour/article/view/92
- DOI: https://doi.org/10.17650/2313-805X-2017-4-2-26-35
- ID: 92
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Abstract
Contrary to the generally accepted opinion about stable DNA as the carrier of hereditary information, in a normal (not just cancer) cell, this molecule is subject to the continuous changes as a result of copying errors (in the course of replication), defects of chromosome segregation (in mitosis) and direct chemical attacks (by reactive oxygen species). Genetic diversification of cells starts during embryonic development and lasts during whole life, generating a phenomenon of the somatic mosaicism. New data on genetic variety of somatic cells lead to a different, than earlier, perception of cancer etiology, pathogenesis and prevention.
About the authors
A. V. Likhtensteyn
Research Institute of Carcinogenesis, N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia
Author for correspondence.
Email: alicht@mail.ru
24 Kashirskoe Shosse, Moscow 115478 Russian Federation
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