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Успехи молекулярной онкологии

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Нейроэндокринные опухоли легкого: современная классификация и алгоритм морфологической диагностики

https://doi.org/10.17650/2313-805X-2017-4-2-46-58

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Аннотация

Нейроэндокринные опухоли (НЭО) бронхолегочной локализации объединяют одну из наиболее распространенных категорий, входящих в гетерогенную группу нейроэндокринных новообразований человека. Опухоли данного типа часто встречаются в практической диагностической работе морфолога, однако их классификация и гистологическая градация не являются точным повторением подходов, разработанных для НЭО желудочно-кишечного тракта и поджелудочной железы. Номенклатура НЭО легких до сих пор основана на использовании термина «карциноид». В последней классификации опухолей легких Всемирной организации здравоохранения, опубликованной в 2015 г., все НЭО данной локализации впервые представлены в одной общей главе. В соответствии с данной классификационной схемой в группу нейроэндокринных пролиферативных процессов входят карциноидные опухоли (включая типичный и атипичный карциноиды), крупноклеточный нейроэндокринный рак, мелкоклеточный рак легкого и диффузная идиопатическая гиперплазия нейроэндокринных клеток как преинвазивное поражение, которое может предшествовать развитию карциноидных опухолей. Каждый вариант НЭО легких имеет характерные морфологические и иммуногистохимические признаки, которые являются ключевыми критериями для диагностики этих опухолей. Морфологические параметры определения степени злокачественности НЭО легких остались неизменными в новой редакции. Однако имеются противоречивые моменты в отношении роли антигена Ki-67 в системе градации НЭО легких при анализе резецированных образцов и малого диагностического материала. Данный обзор обобщает основные ключевые вопросы в области классификации и морфологической диагностики бронхопульмональных НЭО, ответы на которые все еще не являются окончательными. Таким образом, необходимы дополнительные исследования для того, чтобы улучшить наши представления о НЭО данной локализации.

Об авторе

В. В. Делекторская
ФГБУ «Российский онкологический научный центр им. Н.Н. Блохина» Минздрава России
Россия
115478 Москва, Каширское шоссе, 24


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Для цитирования:


Делекторская В.В. Нейроэндокринные опухоли легкого: современная классификация и алгоритм морфологической диагностики. Успехи молекулярной онкологии. 2017;4(2):46-58. https://doi.org/10.17650/2313-805X-2017-4-2-46-58

For citation:


Delektorskaya V.V. Neuroendocrine tumors of the lung: the current classification and pathology diagnosis algorithm. Advances in molecular oncology. 2017;4(2):46-58. (In Russ.) https://doi.org/10.17650/2313-805X-2017-4-2-46-58

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ISSN 2313-805X (Print)
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