MD, PhD, DSc, Head of the Department of Chemical Carcinogenesis of the Research Institute of Carcinogenesis, N.N. Blokhin National Medical Research Oncology Center, Ministry of Health of Russia; member of the Scientific Board of N.N. Blokhin National Medical Research Oncology Center, Ministry of Health of Russia; member of the Russian Committee for Control of Carcinogens; member of the Russian Association of Oncologists; member of the American Association for Cancer Research; member of the European Association for Cancer Research; member of the Working Group of International Agency for Research on Cancer.
Dr. Yakubovskaya was born on June 15th, 1958, in Kimry, Tver Region, Russia
Education
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1975–1980 |
Russian State Medical University, Moscow, Russia (Diploma with Honors; Degree: MD) |
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1980–1986 |
PhD student, Department of Chemical Carcinogenesis, N.N. Blokhin Cancer Research Center, RAMS, Moscow, Russia (Degree: PhD) |
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1995–2005 |
Postdoctoral training, Department of Chemical Carcinogenesis, N.N. Blokhin Cancer Research Center, RAMS, Moscow, Russia (Degree: DSc) |
Subsequent training and positions
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1978–1980 |
Intern researcher, Department of Chemical Carcinogenesis (headed by Academician L.M. Shabad, ). |
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1980–1986 |
PhD student, training in experimental oncology, Department of Chemical Carcinogenesis. Project: Cytochrome P-450 expression and activity in transplantable tumors. |
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1989–1994 |
Researcher at the Laboratory of Carcinogen Screening Methods. Project: Mechanisms of carcinogen activation by cytochrome P-450 isoforms. |
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1994 |
Visiting scientist, Molecular Carcinogenesis Program, AHF, Valhalla, NY, 10595, USA. Supervisor: Dr. Zeev Ronai, Ph.D. Project: Detection of Ki-ras mutations in tumors of patients with lung cancer. Supported by NCI fellowship as part of the US-Russia Scientific Exchange Program. Project: Detection of mutant K-ras in human lung tumors via enriched PCR assay. |
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1995–1997 |
Researcher at the Laboratory of Carcinogen Screening Methods Projects: 1. Molecular effects of genotoxic compounds; 2. Detection of random mutation in genes involved in cell cycle control in tumors and normal tissues of patients with multiple primary cancers; 3. Detection of p53 mutation in breast cancer and extract. |
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1997 |
Visiting scientist, Mutation Research Center, Australia. Supervisor Prof. R.G.H. Cotton. Project: Chemical mismatch cleavage analysis of random p53 gene mutations in human breast cancer. (ICRETT fellowship, UICC) |
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1997–2004 |
Senior Researcher at the Laboratory of Carcinogen Screening Methods Projects: 1. Detection of p53 mutation by chemical cleavage of mismatches; 2. Spontaneous DNA-DNA interaction of homologous linear duplexes. |
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2004 |
Visiting scientist, Université Pierre et Marie Curie, EACR travel fellowship award. Project: Mechanism of spontaneous interaction of DNA fragments containing CA microsatellites, in collaboration with Prof. F. Strauss |
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2004–2009 |
Leading Researcher at the Laboratory of Carcinogen Screening Methods Projects: 1. Detection of point mutations in oncogenes and tumor suppressor genes in tumors: fundamental and methodological aspects; 2. Mechanisms and features of spontaneous DNA-DNA interaction with Holliday junction formation. 3. Role of CA/GT-repetitive sequence in homologous recombination, the main mechanism of DNA double-strand breaks repair |
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2009–currently |
Head of the Department of Chemical Carcinogenesis, Blokhin Russian Cancer Research Center, Ministry of Health of Russia. Projects: 1. Test system for screening of epigenetically active xenobiotics; 2. Epigenetic effects of genotoxic compounds. 3. Genotoxic effects of minor groove-binding ligands; 4. Occupational exposures to antineoplastic drugs; 5. Natural DNA-binding compounds with anticancer activity; 6. Secondary primary tumors of cancer patients; 7. Carcinogens in crumb rubber; 8. Carcinogenic hazards of smoke emissions during open burning of polymer and latex waste; 9. Influence of minor groove-binding ligands on PARP-1 activation; 10. Mutagenic and recombinogenic activity of DNA dyes; 11. GC and SEGRA in cancer therapy; 12. Small DNA-binding compounds for cancer prevention and chemotherapy. |
Awards
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1982 |
Award of Russian Academy of Medical Sciences for the best undergraduate research |
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1994 |
NCI fellowship as part of the US-Russia Scientific Exchange Program |
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1995–1997 |
AACR Career Development Award for Young Cancer Researchers in the Newly Independent States: “Detection of p53 mutation in breast cancer and extract: possible implication for early diagnosis” |
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1997 |
ICRETT fellowship from the UICC to visit Mutation Research Center. Project: Chemical mismatch cleavage analysis of random p53 gene mutations in human breast cancer |
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2001 |
Recognition of Yakubovskaya et al. paper “Interaction of linear homologous DNA duplexes via Holliday junction formation” as the priority publication of the European Journal of Biochemistry |
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2003 March |
Diploma of the Ministry of Education of the Russian Federation for Excellent Supervision of Research of Junior Investigators (PhD.students: Gasanova-Markina Victoria Kabilanovna) |
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2004 |
EACR travel fellowship award (Université Pierre et Marie Curie) |
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2008 |
Travel Award of the Russian Foundation for Basic Research for participation in the 59th Annual meeting of the ASHG (Philadelphia, November 2008) |
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2010 |
Travel Award of the Russian Foundation for Basic Research for participation in the FASEB Research Conference “Alternatively structured DNA”, 2010 |
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2013 |
Diploma of the Ministry of Health of Russia for research in the field of chemical carcinogenesis |
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2017 |
Diploma for the best oral presentation at the 12th International Conference & 5th Asian Congress on Environmental Mutagens |
Other experience and professional memberships
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1997–2010 |
Member, Human Genome Polymorphism Society |
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1999–currently |
Member, Federation of European Biochemical Societies |
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2003–currently |
Member, European Association for Cancer Research |
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2007–currently |
Member, American Association for Cancer Research |
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2014–currently |
Deputy Editor-in-Chief, Russian Journal “Advances in Molecular Oncology” |
Participation in the organizing committees of conferences/meetings
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2014 |
Meeting “Cancer Research and Radiology of the Commonwealth of Independent States”, Kazan |
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2015 |
EMBO Workshop “Cellular and Molecular Mechanism of Tumor–Microenvironment Crosstalk”, Tomsk |
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2015 |
Conference “Advances in Molecular Oncology”, Moscow |
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2016 |
Meeting “Cancer Research and Radiology of the Commonwealth of Independent States”, Minsk |
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2016 |
II Saint Petersburg Cancer Research Forum, Experimental research (Petrovskie chteniya), St-Peterburg |
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2016 |
V Meeting of Russian Physiologists, Sochi |
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2016 |
Conference “Advances in Molecular Oncology”, Moscow |
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2017 |
Meeting “Cancer Research of the Commonwealth of Independent States”, Ufa |
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2017 |
Conference “Advances in Molecular Oncology”, Moscow |
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2018 |
Meeting “Cancer Research and Radiology of the Commonwealth of Independent States”, Sochi |
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2018 |
Conference “Advances in Molecular Oncology”, Moscow |
