Email this article The therapeutic potential of curcumin for the treatment of glioblastoma multiforme
- Authors: Kushnir T.I.1,2, Arnotskaya N.E.1, Kudryavtsev I.A.1, Shevchenko V.E.1
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Affiliations:
- Research Institute of Carcinogenesis, N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
- Institute of Biochemical Technology and Nanotechnology, Peoples’ Friendship University of Russia
- Issue: Vol 7, No 1 (2020)
- Pages: 8-16
- Section: REVIEW ARTICLES
- Published: 28.03.2020
- URL: https://umo.abvpress.ru/jour/article/view/252
- DOI: https://doi.org/10.17650/2313-805X-2020-7-1-8-16
- ID: 252
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Abstract
Glioblastoma multiforme (GBM), a grade IV astrocytoma, is the most common and deadly type of primary malignant brain tumor, with a patien’s median survival rate ranging from 12 to 15 months. Over the last fifteen years, the treatment for GBM has included maximal safe surgical resection with combination radiotherapy and adjuvant temozolomide chemotherapy. The low efficacy of mentioned therapies has forced researchers to explore an appropriate alternative or complementary treatment for GBM. It has been shown that curcumin has therapeutic potentials to fight against GBM via affecting on cell proliferation, apoptosis, cell cycle, invasion and angiogenesis pathways. In addition, curcumin possess a synergistic impact with chemotherapeutic agents. Herein, we summarized the current findings on curcumin as potential therapeutic agent in the treatment of GBM.
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About the authors
T. I. Kushnir
Research Institute of Carcinogenesis, N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia; Institute of Biochemical Technology and Nanotechnology, Peoples’ Friendship University of Russia
Author for correspondence.
Email: winard2@mail.ru
ORCID iD: 0000-0001-9626-6847
Build. 15, 24 Kashirskoe Shosse, Moscow 115478; Build. 2, 10 Miklukho-Maklaya St., Moscow 117198
Russian FederationN. E. Arnotskaya
Research Institute of Carcinogenesis, N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Email: fake@neicon.ru
ORCID iD: 0000-0002-0154-8604
Build. 15, 24 Kashirskoe Shosse, Moscow 115478
Russian FederationI. A. Kudryavtsev
Research Institute of Carcinogenesis, N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Email: fake@neicon.ru
ORCID iD: 0000-0001-7588-1066
Build. 15, 24 Kashirskoe Shosse, Moscow 115478 Russian Federation
V. E. Shevchenko
Research Institute of Carcinogenesis, N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Email: fake@neicon.ru
ORCID iD: 0000-0002-0401-9900
Build. 15, 24 Kashirskoe Shosse, Moscow 115478 Russian Federation
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