Email this article The study of new anticancer drug delivery system based on the boron nitride nanoparticles
- Authors: Zhitnyak I.Y.1,2, Sukhorukova I.V.3,4, Koval’skiy A.M.3,4, Matveev A.T.3,4, Bychkov I.N.5,6, Shtanskiy D.V.3,4, Glushankova N.A.1,2
-
Affiliations:
- Research Institute of Carcinogenesis, N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia
- 24 Kashirskoe Shosse, Moscow, 115478, Russia
- National University of Science and Technology, Moscow Institute of Steel and Alloys
- 4 Leninskiy prospekt, Moscow, 119049, Russia
- N.I. Pirogov Russion National Research Medical University
- 1 Ostrovityanova St., Moscow, 117997, Russia
- Issue: Vol 3, No 2 (2016)
- Pages: 34-41
- Section: RESEARCH ARTICLES
- Published: 07.06.2016
- URL: https://umo.abvpress.ru/jour/article/view/60
- DOI: https://doi.org/10.17650/2313-805X.2016.3.2.34-41
- ID: 60
Cite item
Full Text
Abstract
The main problem in the treatment of many cancers is multidrug resistance due to tumor progression. Using nanosized drug delivery systems allows to overcome the mechanisms of multidrug resistance of cancer, in this case, chemotherapeutic agents can effectively introduce into cancer cells by endocytosis and accumulate near the nucleus and far from ATP-binding cassette transporters. Creation of boron nitridebased drug delivery nanocarriers with high chemical and oxidative stability is one of the perspective ways. Using chemical vapor deposition spherical boron nitride particles,100–150 nm in diameter (BNNPs), with peculiar petal-like surfaces or smooth surfaces were fabricated. BNNPs were loaded with doxorubicin. Drug loading efficacy of BNNPs-DOX was about 0.095 mg/mg of particles. BNNPs-DOX were relatively stable at neutral pH, whereas DOX is effectively released from the BNNPs at acidic pH (pH 4.5–5.5). Using confocal microscopy, the uptake of BNNPs-DOX by IAR-6-1, KB-3-1, К562 cells and multidrug resistant КВ-8-5 и IS-9 cells was studied. Most of BNNPs-DOX had been co-localized with LysoTracker, indicating that BNNPs-DOX are located in the endosomes/lysosomes after intracellular delivery.
About the authors
I. Yu. Zhitnyak
Research Institute of Carcinogenesis, N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia; 24 Kashirskoe Shosse, Moscow, 115478, Russia
Email: fake@neicon.ru
Russian Federation
I. V. Sukhorukova
National University of Science and Technology, Moscow Institute of Steel and Alloys; 4 Leninskiy prospekt, Moscow, 119049, Russia
Email: fake@neicon.ru
Russian Federation
A. M. Koval’skiy
National University of Science and Technology, Moscow Institute of Steel and Alloys; 4 Leninskiy prospekt, Moscow, 119049, Russia
Email: fake@neicon.ru
Russian Federation
A. T. Matveev
National University of Science and Technology, Moscow Institute of Steel and Alloys; 4 Leninskiy prospekt, Moscow, 119049, Russia
Email: fake@neicon.ru
Russian Federation
I. N. Bychkov
N.I. Pirogov Russion National Research Medical University; 1 Ostrovityanova St., Moscow, 117997, Russia
Email: fake@neicon.ru
Russian Federation
D. V. Shtanskiy
National University of Science and Technology, Moscow Institute of Steel and Alloys; 4 Leninskiy prospekt, Moscow, 119049, Russia
Email: fake@neicon.ru
Russian Federation
N. A. Glushankova
Research Institute of Carcinogenesis, N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia; 24 Kashirskoe Shosse, Moscow, 115478, Russia
Author for correspondence.
Email: natglu@hotmail.com
Russian Federation
References
Supplementary files
