The balance between deception and adaptation: vasculogenic mimicry as a tumor survival strategy

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Abstract

Vasculogenic mimicry is a unique process through which tumor cells imitate normal vascular endothelial cells to secure access to the blood flow. In this review, we consider molecular mechanisms underlying this phenomenon and its importance in the context of solid tumor development. We have analyzed survival strategies of tumor cells using vasculogenic mimicry and described potential therapeutic approaches aimed at tumor growth and metastasis suppression. Highlighting the methods of histological and molecular identification of vasculogenic mimicry promotes better understanding of this phenomenon and its early diagnosis. The review focuses on the necessity of further research in the area of vasculogenic mimicry to conceptualize mechanisms underlying carcinogenesis. We have analyzed 109 articles from the leading biomedical databases including SciVerse Scopus, PubMed, Web of Science and RSCI (Russian Science Citation Index) which allowed us to summarize current scientific data and identify the key trends in the area of molecular oncology.

About the authors

E. A. Prosekina

N.N. Petrov National Medical Research Center of Oncology, Ministry of Health of Russia

Author for correspondence.
Email: elizaveta.prosekina@gmail.com
ORCID iD: 0000-0002-1235-3829

Elizaveta Andreevna Prosekina 

68 Leningradskaya St., Pesochny Settlement, Saint Petersburg 197758, Russia 

Russian Federation

V. A. Shapkina

Saint Petersburg State University

Email: fake@neicon.ru
ORCID iD: 0000-0003-1843-2808

7/9 Universitetskaya Emb., Saint Petersburg 199034, Russia 

Russian Federation

A. E. Karpov

N.N. Petrov National Medical Research Center of Oncology, Ministry of Health of Russia

Email: fake@neicon.ru
ORCID iD: 0000-0003-3913-9619

68 Leningradskaya St., Pesochny Settlement, Saint Petersburg 197758, Russia 

Russian Federation

E. Yu. Fedorutseva

National Research Tomsk State University

Email: fake@neicon.ru
ORCID iD: 0009-0001-3577-8379

36 Lenin Prospekt, Tomsk 634050, Russia 

Russian Federation

A. S. Artemyeva

N.N. Petrov National Medical Research Center of Oncology, Ministry of Health of Russia

Email: fake@neicon.ru
ORCID iD: 0000-0002-2948-397X

68 Leningradskaya St., Pesochny Settlement, Saint Petersburg 197758, Russia 

Russian Federation

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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 57560 от  08.04.2014.