Email this article CYCLOPHILIN A: STRUCTURE AND FUNCTIONS
- Authors: Kalinina A.A.1, Khromykh L.M.1, Kazansky D.B.1
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Affiliations:
- N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
- Issue: Vol 4, No 4 (2017)
- Pages: 17-23
- Section: CLINICAL SURVEILLANCE
- Published: 02.12.2017
- URL: https://umo.abvpress.ru/jour/article/view/114
- DOI: https://doi.org/10.17650/2313-805X-2017-4-4-17-23
- ID: 114
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Abstract
Cyclophilins belong to a large family of ancient conservative proteins with peptidyl-prolyl-cis-trans isomerase activity. The main member of this family – cyclophilin A – was discovered as an intracellular ligand for cyclosporine A. Further investigations revealed a wide range of functions of cyclophilin A. Cyclophilin A is involved in T-cell signaling, it takes part in folding, assembly and intracellular transport of proteins, as well as acts as an antioxidant. Different cell types secrete cyclophilin A under infection or oxidative stress. Cyclophilin A is one of the main factors involved in inflammation and pathogenesis of autoimmune, cardiovascular and other diseases. This protein is thought to take part in tumor progression. In this review we describe the structure of cyclophilin A and its main known functions in health and disease.
About the authors
A. A. Kalinina
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Author for correspondence.
Email: aakalinina89@gmail.com
24 Kashirskoe Shosse, Moscow 115478
Russian FederationL. M. Khromykh
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Email: fake@neicon.ru
24 Kashirskoe Shosse, Moscow 115478
Russian FederationD. B. Kazansky
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Email: fake@neicon.ru
24 Kashirskoe Shosse, Moscow 115478
Russian FederationReferences
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