Модели сарком мягких тканей in vitro: фундаментальные и клинические аспекты

Диагностика и подбор эффективной терапии сарком мягких тканей (СМТ) затруднены в связи с низкой распространенностью и значительной гистологической вариабельностью данных опухолей. Развитие молекулярно-генетических методов тестирования направлено на улучшение дифференциальной диагностики различных типов СМТ и поиск генетических нарушений, которые могут являться потенциальными мишенями для терапии. Разработка эффективных методов лечения требует адекватных доклинических моделей, способных воспроизводить биологические особенности опухолей. В статье представлены молекулярно-генетические методы тестирования для диагностики и терапии СМТ, достижения в получении моделей in vitro СМТ, проблемы их использования в доклинических исследованиях, а также перспективы использования первичных клеточных линий для персонализированного лечения.

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